Nanomaterials
are of significant interest in acetaminophen (APAP)
detection in pharmaceutical samples. Herein, a carbon black/single-crystalline
rodlike bismuth sulfide (CB/Bi2S3) composite
prepared by an ultrasonic method is reported and utilized for the
rapid analysis of APAP. The highly oriented edge reactive sites of
the CB/Bi2S3 composite promoted synergy and
good electrochemical sensing performance with a fast electron transfer
rate and low overpotential (0.35 V). Therefore, a CB/Bi2S3 composite-modified glassy carbon electrode (GCE) was
applied to the selective determination of APAP by the voltammetric
technique. The CB/Bi2S3 composite-modified electrode
showed the lowest limit of detection of APAP (1.9 nM) with excellent
sensitivity. The proposed CB/Bi2S3/GCE platform
exhibited high selectivity, excellent stability (87.15%), and reproducibility.
Also, the CB/Bi2S3/GCE sensor was then successfully
used to analyze an APAP pharmaceutical sample and exhibited satisfactory
outcomes. Therefore, the CB/Bi2S3-modified GCE
sensor platform would be a low-cost and robust GCE electrode material
for APAP detection.