Carboxyl-functionalized mesoporous silica nanoparticles for the controlled delivery of poorly water-soluble non-steroidal anti-inflammatory drugs

Gou, Kaijun; Wang, Yumei; Guo, Xianmou; Wang, Yuxin; Bian, Yan; Zhao, Haiqing; Guo, Yingyu; Pang, Yue; Xie, Linlin; Li, Sanming; Li, Heran

doi:10.1016/j.actbio.2021.07.023

Cited by 46 publications

(30 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No absorption peak of DDP was found, indicting amorphous form of DDP after successful loading. 44 Additionally, diffraction peak of USPIO-Au was shown in XRD profile, suggesting a successful synthesis of the composite nanomaterial. See Figure 1h for FTIR spectrum of nanoparticles.…”

Section: Characterization Of Morphology and Physical And Chemical Propertiesmentioning

confidence: 90%

Treatment of microvascular invasion in hepatocellular carcinoma with drug‐loaded nanocomposite platform under synergistic effect of magnetic field/near‐infrared light

Liu

Zhu

et al. 2021

J Biomed Mater Res

View full text Add to dashboard Cite

Despite progress in clinical treatment, microvascular invasion (MVI) remains a major factor for frequent recurrence and metastasis of hepatocellular carcinoma (HCC) after liver resection and surgery. Thus, this study constructed a target nanoplatform (αCD97-USPIO-Au-DDP) with magnetic field/near-infrared (NIR) light response using ultrasmall superparamagnetic iron oxide-gold nanoporous spheres (USPIO-Au) as multifunctional nanocarrier. Anticancer drug cisplatin (DDP) was loaded, and specifically expressed CD97 protein in MVI was taken as the therapeutic target. The αCD97-USPIO-Au-DDP showed favorable photothermal and stable properties under the NIR light at 808 nm wavelength. As suggested by in vitro and in vivo research, this composite nanopreparation could effectively reduce damage to normal organs and showed good biocompatibility. Excellent magnetic targeting function of nanocarrier and modification of αCD97 strengthened accumulation of composite nanodrug in tumor to inhibit tumor growth. This system may have important ramifications for treatment of MVI in HCC.

show abstract

Section: Characterization Of Morphology and Physical And Chemical Propertiesmentioning

confidence: 90%

Treatment of microvascular invasion in hepatocellular carcinoma with drug‐loaded nanocomposite platform under synergistic effect of magnetic field/near‐infrared light

Liu

Zhu

et al. 2021

J Biomed Mater Res

View full text Add to dashboard Cite

show abstract

“…The few exceptions that do not contain this chemical function are phenylbutazone, celecoxib and oxicams (isoxicam, meloxicam, piroxicam) [ 101 ]. NSAIDs are commonly used in the treatment of pain, fever and anti-inflammatory diseases [ 87 ].…”

Section: Anti-inflammatory Agentsmentioning

confidence: 99%

“…All NSAIDs are inhibitors of COX, an enzyme responsible for the synthesis of prostaglandins [ 105 ]. The main side effects resulting from the therapy using NSAIDS are gastric irritation leading to the occurrence of peptic ulcers, irritation of gastrointestinal mucosa, inhibition of platelet aggregation and adverse reactions to the kidneys [ 86 , 87 , 106 ].…”

Section: Anti-inflammatory Agentsmentioning

confidence: 99%

“…Mesoporous silica-based DDSs are especially useful for the incorporation of poorly water-soluble drug molecules. In order to solve the problem of low solubility, many different approaches have been put forward and investigated in depth to improve the dissolution kinetics and bioavailability of poorly water-soluble drugs such as solid dispersions, nanosuspensions, spray drying, cryogenic technologies and prodrug strategies [ 87 , 115 , 155 ]. It was shown that the problem of low drug solubility can also be overcome by the usage of a carrier substance like mesoporous silica during the preparation of sophisticated drug delivery platforms.…”

Section: Mesoporous Material-based Drug Delivery Systems For Anti-inf...mentioning

confidence: 99%

“…Inflammation is the first response of the human immune system to tissue injury, irritation or infection [ 86 ]. Long-term inflammation can result in the damage of tissues or even lead to chronic diseases such as rheumatoid arthritis, asthma and other inflammatory vascular diseases [ 87 , 88 ]. It is also considered a serious risk factor for cancer [ 89 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Moritz

Geszke-Moritz

2022

Pharmaceutics

View full text Add to dashboard Cite

Interest in the use of mesoporous materials as carriers of medicinal substances has been steadily increasing in the last two decades. Mesoporous carriers have application in the preparation of delivery systems for drugs from various therapeutic groups; however, their use as the carriers of anti-inflammatory agents is particularly marked. This review article, with about 170 references, summarizes the achievements in the application of mesoporous materials as the carriers of anti-inflammatory agents in recent years. This article will discuss a variety of mesoporous carriers as well as the characteristics of their porous structure that determine further use of these materials in the field of medical applications. Special attention will be paid to the progress observed in the construction of stimuli-responsive drug carriers and systems providing site-specific drug delivery. Subsequently, a review of the literature devoted to the use of mesoporous matrices as the carriers of anti-inflammatory drugs was carried out.

show abstract

Prenatal Silicon Dioxide Nanoparticles Exposure Reduces Female Offspring Fertility Without Affecting Males

Lei,

Zhu,

Wei

et al. 2024

Advanced Science

View full text Add to dashboard Cite

Silicon dioxide nanoparticles (SiO2 NPs) are widely utilized in biomedicine due to their controllable size and biocompatibility. While previous studies have demonstrated that prenatal exposure to SiO2 NPs can traverse the placental barrier and induce neurotoxicity in offspring. However, their reproductive toxicity remains unclear. Here, it is found that prenatal SiO2 NPs exposure led to subfertility in female offspring, evidenced by decreased ovulation potential, ovarian reserve, and litter size. In contrast, male offspring maintained normal sperm production and fertility. Mechanistic analyses revealed that prenatal SiO2 NPs exposure disrupted meiotic recombination and increased oocyte apoptosis, resulting in reduced postnatal primordial follicle formation in females. Conversely, meiotic recombination occurring postnatally in male offspring remained unaffected. Notably, treatment with carboxylate (COOH)‐functionalized SiO2 nanoparticles (SiO2‐COOH NPs) has a minimal impact on fertility in female offspring. Further research, including clinical studies, is needed to confirm these findings in humans. These findings demonstrated gender‐specific reproductive toxicity induced by prenatal SiO2 NPs exposure and highlighted the importance of considering nanoparticle safety in prenatal contexts.

show abstract

Carboxyl-functionalized mesoporous silica nanoparticles for the controlled delivery of poorly water-soluble non-steroidal anti-inflammatory drugs

Cited by 46 publications

References 53 publications

Treatment of microvascular invasion in hepatocellular carcinoma with drug‐loaded nanocomposite platform under synergistic effect of magnetic field/near‐infrared light

Treatment of microvascular invasion in hepatocellular carcinoma with drug‐loaded nanocomposite platform under synergistic effect of magnetic field/near‐infrared light

Mesoporous Materials as Elements of Modern Drug Delivery Systems for Anti-Inflammatory Agents: A Review of Recent Achievements

Prenatal Silicon Dioxide Nanoparticles Exposure Reduces Female Offspring Fertility Without Affecting Males

Contact Info

Product

Resources

About