Carboxylic acid chlorides as arylating agents in the palladium-catalyzed Heck reaction - The Blaser reaction

Abstract

Heck reaction is a powerful tool in organic synthesis to perform CC couplings by which functionalized alkenes can be obtained under mild conditions and great selectivity. Developing alternative methodologies where arylating agents different from the conventional aryl halides or triflates can be introduced with success is one of the areas of research nowadays. By these methodologies it is envisaged to provide better conditions for the industrial application of the palladium-catalyzed Heck CC coupling. One of the aims of this research is to introduce non expensive arylating agents as well as to minimize waste. In this regard we describe in this paper some studies present in the literature where acid chlorides and other arylcarboxylic acid derivatives are employed as arylating agents in the Heck reactions.