Carcinoembryonic antigen: Function in metastasis by human colorectal carcinoma

Jessup, J. Milburn; Thomas, Peter

doi:10.1007/bf00047341

Cited by 83 publications

(25 citation statements)

References 82 publications

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“…Multiple sequential steps are required to enable a malignant cell to establish metastases at a distant site (23). As the first step, a tumor cell must be released from the primary tumor by loss of cell-cell adhesion.…”

Section: Discussionmentioning

confidence: 99%

“…Also, CEA has been implicated in the development of hepatic metastases from colorectal cancers (23,28). It has been shown that poorly metastatic human colon cancer cell lines become highly metastatic when transfected with the cDNA coding for CEA by a mechanism not yet fully understood (29).…”

Section: Discussionmentioning

confidence: 99%

“…A possible explanation for this 2 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1 2 3 1.0 0.5 observation is that the LISP-E11 cell clone has been adaptively selected for its ability to rapidly recognize, adhere to and spread on fibronectin, which is present in the space of Disse in the liver. The space of Disse contains a discontinuous extracellular matrix composed of collagen types I and IV and fibronectin, but not laminin (23). However, laminin is present in the basement membranes of the endothelium of central and portal veins.…”

Section: Discussionmentioning

confidence: 99%

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Functional differences between two morphologically distinct cell subpopulations within a human colorectal carcinoma cell line

Solimene

Carneiro

Melati

et al. 2001

Braz J Med Biol Res

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The LISP-I human colorectal adenocarcinoma cell line was isolated from a hepatic metastasis at the Ludwig Institute, São Paulo, SP, Brazil. The objective of the present study was to isolate morphologically different subpopulations within the LISP-I cell line, and characterize some of their behavioral aspects such as adhesion to and migration towards extracellular matrix components, expression of intercellular adhesion molecules and tumorigenicity in vitro. Once isolated, the subpopulations were submitted to adhesion and migration assays on laminin and fibronectin (crucial proteins to invasion and metastasis), as well as to anchorage-independent growth. Two morphologically different subpopulations were isolated: LISP-A10 and LISP-E11. LISP-A10 presents a differentiated epithelial pattern, and LISP-E11 is fibroblastoid, suggesting a poorly differentiated pattern. LISP-A10 expressed the two intercellular adhesion molecules tested, carcinoembryonic antigen (CEA) and desmoglein, while LISP-E11 expressed only low amounts of CEA. On the other hand, adhesion to laminin and fibronectin as well as migration towards these extracellular matrix proteins were higher in LISP-E11, as expected from its poorly differentiated phenotype. Both subpopulations showed anchorage-independent growth on a semi-solid substrate. These results raise the possibility that the heterogeneity found in the LISP-I cell line, which might have contributed to its ability to metastasize, was due to at least two different subpopulations herein identified.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Functional differences between two morphologically distinct cell subpopulations within a human colorectal carcinoma cell line

Solimene

Carneiro

Melati

et al. 2001

Braz J Med Biol Res

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“…Armitage et al [9] found the highest levels of CEA in patients with well differen tiated tumors, whereas other studies [10,11] have reported that moderately differentiated tumors were associated with higher serum CEA levels than both well and poorly differentiated tumors. It has also been reported that CEA has a direct or indirect role in the metastatic process of colorectal tumors [12], Jessup and Thomas [13] have shown a correlation between circulating CEA levels in pa tients and the ability of the tumor to metastasize to the liver. In our study, Mp tumors were more frequently asso ciated with higher serum levels of CEA and this might be related to the higher malignant potential and higher inci dence of liver métastasés observed in these tumors.…”

Section: Discussionmentioning

confidence: 99%

The Clinical Significance of the Histologic Subclassification of Colorectal Carcinoma

Teixeira

Tanaka²,

Haruma³

et al. 1993

Oncology

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According to the histologic features at the deepest level of tumor invasion (the tumor apex), we classified colorectal carcinomas as follows: well differentiated (W), moderately differentiated (M), and mucinous (Muc). By assessing its glandular configuration and cellular arrangement, the M type was further subdivided in to two different groups: moderately well differentiated (Mw) and moderately poorly differentiated (Mp) carcinomas. In our sample there were 56 W, 53 Mw, 20 Mp and 13 Muc tumors. The malignant potential of each tumor was evaluated by examining for the presence or absence of lymphatic invasion, venous invasion, lymph node metastases and liver metastases. In comparison with the other tumors, the Mp tumors proved to harbor the highest malignant potential, exhibiting a higher incidence of lymphatic invasion (95%, 19/20 of the cases), venous invasion (75%, 15/20 of the cases), lymph node metastases (80%, 16/20 of the cases), and liver metastases (40%, 8/20 of the cases). Colorectal carcinomas are composed of multiple cell populations with different biological and malignant properties, and through the histologic sub-classification we could identify that Mp tumors have the highest potential to invade normal tissue and metastasize.

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“…The structural similarity of cea to intercellular adhesion molecule 1 might alter cell adhesion, which might in turn have a role in cancer invasion and metastasis. Thus, cea might play a role in the metastatic process [31][32][33][34] . Evidence for the role of cea in cancer dissemination was revealed in a study by Hostetter et al 35 , who showed that the rate of liver metastasis in mice transplanted with colorectal tumours increased to 48% from 2% after cea injection.…”

Section: Levels Of Carcinoembryonic Antigen (Cea) and Carbohydrate Anmentioning

confidence: 99%

Diagnostic Value of Preoperative Serum Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 in Colorectal Cancer

Polat

Duman

et al. 2014

Current Oncology

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Background: Since the first introduction of tumour markers, their usefulness for diagnosis has been a challenging question. The aim of the present prospective study was to investigate, in colorectal cancer patients, the relationship between preoperative tumour marker concentrations and various clinical variables. Methods: The study prospectively enrolled 131 consecutive patients with a confirmed diagnosis of colorectal carcinoma and 131 age- and sex-matched control subjects with no malignancy. The relationships of the tumour markers carcinoembryonic antigen (cea) and carbohydrate antigen (ca) 19-9 with disease stage, tumour differentiation (grade), mucus production, liver function tests, T stage, N stage, M stage were investigated. Results: Serum concentrations of cea were significantly higher in the patient group than in the control group (p = 0.001); they were also significantly higher in stage iii (p = 0.018) and iv disease (p = 0.001) than in stage i. Serum concentrations of cea were significantly elevated in the presence of spread to lymph nodes (p = 0.005) in the patient group. Levels of both tumour markers were significantly elevated in the presence of distant metastasis in the patient group (p = 0.005 for cea; p = 0.004 for ca 19-9). Conclusions: Preoperative levels of cea and ca 19-9 might provide an estimate of lymph node invasion and distant metastasis in colorectal cancer patients.

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Carcinoembryonic antigen: Function in metastasis by human colorectal carcinoma

Cited by 83 publications

References 82 publications

Functional differences between two morphologically distinct cell subpopulations within a human colorectal carcinoma cell line

Functional differences between two morphologically distinct cell subpopulations within a human colorectal carcinoma cell line

The Clinical Significance of the Histologic Subclassification of Colorectal Carcinoma

Diagnostic Value of Preoperative Serum Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 in Colorectal Cancer

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