Carcinoembryonic antigen in the bile in patients with pancreatic and biliary cancer correlation with cytology and percutaneous transhepatic cholangiography

Tatsuta, Masaharu; Yamamura, Hisako; Yamamoto, Reiko; Morii, Takeshi; Okuda, Shujiro; Tamura, Hiroshi

doi:10.1002/1097-0142(19821215)50:12<2903::aid-cncr2820501233>3.0.co;2-m

Cited by 17 publications

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“…The fluid was obtained by ultrasonicallyguided percutaneous fine-needle aspiration biopsy. 2 The patients comprised 6 patients with malignant pancreatic cyst (5 mucinous cystadenocarcinomas and 1 retention cyst due to pancreatic carcinoma), and 1 1 patients with benign cysts (3 serous cystadenoma and 8 pseudocysts accompanying or following acute or chronic pancreatitis).…”

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Values of carcinoembryonic antigen, elastase 1, and carbohydrate antigen determinant in aspirated pancreatic cystic fluid in the diagnosis of cysts of the pancreas

Tatsuta

Ichii

Noguchi

et al. 1986

Cancer

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The levels of carcinoembryonic antigen (CEA), elastase 1, and carbohydrate antigen determinant (CA 19-9) in the pancreatic cystic fluid and the serum from five patients with cystadenocarcinoma of the pancreas, one patient with retention cyst due to pancreatic carcinoma, three patients with cystadenoma, and eight patients with benign pseudocyst accompanying or following pancreatitis, were determined by immunoassay technique. Fluid from pancreatic cysts was obtained by ultrasonically-guided percutaneous fine-needle aspiration biopsy. The specimens were centrifuged and the supernatant was used for the measurement of CEA, elastase 1, and CA 19-9, while the cell pellet was examined cytologically. The levels of CEA in the aspirated fluid were significantly higher in patients with malignant cysts of the pancreas than in those with benign cystadenomas and pseudocysts. In contrast, the levels of elastase 1 were significantly lower in patients with malignant cysts than in those with benign pancreatic cysts. Although the levels of CA 19-9 were significantly higher in patients with malignant cysts than in those with pseudocysts, the overlap between the values of patients with malignant and benign pancreatic cysts is too great. The serum CA 19-9 was most useful, however, to distinguish an individual patient with malignant cysts of the pancreas from those with benign pancreatic cyst, since there were no significant differences between the levels of serum CEA and elastase 1 in patients with malignant and benign pancreatic cysts. Correct diagnoses were made cytologically in 4 (66.7%) of 6 patients with malignant cysts. In two patients with malignant cyst, in whom no cancer cells were detectable in the aspirated materials, levels of CEA were abnormally high, but high levels of elastase 1 did not occur. Therefore, the combined measurement of CEA and elastase 1 in the aspirated cystic fluid of the pancreas could be used as an aid in diagnosis of malignant cysts of the pancreas.

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confidence: 99%

Values of carcinoembryonic antigen, elastase 1, and carbohydrate antigen determinant in aspirated pancreatic cystic fluid in the diagnosis of cysts of the pancreas

Tatsuta

Ichii

Noguchi

et al. 1986

Cancer

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“…The bile obtained from intrahepatic choledocholithiasis) are related to immunologically cross-reacting materials that are rich in bile. [28][29][30] CEA bile ducts containing stones in hepatolithiasis was more reactive than the bile obtained from the unin-belongs to a large gene family, which includes normal fetal antigen, nonspecific cross-reacting antigen, nonvolved bile duct from the same patient ( Fig. 2A).…”

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Carcinoembryonic antigen and blood group-related carbohydrate antigens in glycoproteins in human bile in hepatolithiasi

Sasaki

1996

Hepatology

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We investigated whether carbohydrate antigens on cholangitis, 2,4 in which the proliferated peribiliary biliary glycoproteins and carcinoembryonic antigen glands secrete large amounts of acid (sialylated and (CEA) are related to hepatolithiasis. CEA, ABO, and sulfated) or neutral mucin into the biliary lumen. 4 Most Lewis blood group-related antigens, as well as sialyl-intrahepatic calculi consist of calcium-bilirubinate Tn antigen in hepatic bile, were analyzed by Western (brown pigment) stones. 4,5 Bacterial infection, bile stablotting in samples from 12 patients with hepatolithiasis sis, and an alteration of the bile composition are and 37 with other biliary diseases (choledocholithiasis, thought to be responsible for the nucleation, formation, 13; cholecystolithiasis, 5; acute cholecystitis, 2; chol-and maturation of intrahepatic calculi. 6,7 In addition, angiocarcinoma, 5; common bile duct carcinoma, 4; panthe increased mucin production and secretion from the creatic carcinoma, 6; and metastatic carcinoma of liver, bile ducts may play an important role in the develop-2). CEA was positive on mucinous glycoprotein in six patients (50%) with hepatolithiasis and one case (17%) ment of intrahepatic calculi. 4,5,8 Biliary mucin, particuwith pancreatic carcinoma. CEA was also positive on a larly sulfated, reportedly promotes the formation of calglycoprotein of approximately 200 kd in eight patients cium-bilirubinate stones. 4,7 Histochemically, these (67%) with hepatolithiasis and two (33%) with pancreatic stones are composed of alternating multilayers of mucarcinoma. Lewis X was detected on the mucinous glyco-cin and pigment (calcium-bilirubinate) on their cut surprotein in almost all samples, as well as on glycoproteins face, suggesting that mucin bridges the pigment layers of approximately 180 kd in all hepatolithiasis samples and participates in the precipitation of calcium-biliruand approximately half of those from patients with other binate. and proteoglycans play an important role in cell-to-(50%) with common bile duct carcinoma, and all pancreatic carcinoma samples. Mucinous glycoprotein and gly-cell adhesion and recognition 10-13 and also have a close coproteins containing CEA and Lewis X antigens are en-relationship with a specific bacterial infection.14,15 Carriched in hepatic bile of hepatolithiasis, and they may be cinoembryonic antigen (CEA), which is widely used as closely related to the formation of intrahepatic calculi. a tumor marker, 16 also functions as an intercellular Sialyl-Tn antigen in biliary mucinous glycoprotein will adhesion molecule 17,18 and also binds and aggregates be a good marker of biliary and pancreatic carcinoma, bacteria. 19,20 Immunohistochemical studies 21-23 have and probably for cholangiocarcinoma complicated with disclosed that the biliary epithelial cells at different hepatolithiasis. (HEPATOLOGY 1996;23:258-263.) anatomic levels have a characteristic distribution of carbohydrate antigens, and their altered distribution Hepatolithiasis is quite common in the Fa...

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Treatment of Pancreatic Cancer

Malt¹

1983

JAMA

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Carcinoembryonic antigen in the bile in patients with pancreatic and biliary cancer correlation with cytology and percutaneous transhepatic cholangiography

Cited by 17 publications

References 20 publications

Values of carcinoembryonic antigen, elastase 1, and carbohydrate antigen determinant in aspirated pancreatic cystic fluid in the diagnosis of cysts of the pancreas

Values of carcinoembryonic antigen, elastase 1, and carbohydrate antigen determinant in aspirated pancreatic cystic fluid in the diagnosis of cysts of the pancreas

Carcinoembryonic antigen and blood group-related carbohydrate antigens in glycoproteins in human bile in hepatolithiasi

Treatment of Pancreatic Cancer

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