Cardiac and skeletal muscle disease in systemic sclerosis (scleroderma): A high risk association

Follansbee, William P.; Zerbe, Tony R.; Medsger, Thomas A.

doi:10.1016/0002-8703(93)90075-k

Cited by 192 publications

(112 citation statements)

References 18 publications

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“…One study reported that muscle involvement in scleroderma as a poor prognostic feature impacting survival, especially those of male gender, or early diffuse disease, or interstitial lung disease (9). Muscle involvement has also been associated with sudden cardiac death (10,11).…”

Section: Introductionmentioning

confidence: 99%

Independent Association of Severity of Muscle Weakness With Disability as Measured by the Health Assessment Questionnaire Disability Index in Scleroderma

Paik

Wigley

Mejia

et al. 2016

Arthritis Care & Research

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Section: Introductionmentioning

confidence: 99%

Independent Association of Severity of Muscle Weakness With Disability as Measured by the Health Assessment Questionnaire Disability Index in Scleroderma

Paik

Wigley

Mejia

et al. 2016

Arthritis Care & Research

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“…In addition, postmortem serological tests for antibodies to viruses causing myocarditis, such as Coxsackie A9 and Bs, were negative. The complication of heart disease is an indicator of a relatively poorer prognosis in SSc patients [2]. The histopathology of hearts of these patients exhibits the contraction band necrosis and subsequent replacement fibrosis of myocardium to endocardium without extramyocardial and intramyocardial stenotic changes in the coronary vessels; therefore, functional ischemia probably due to Raynaud's phenomenon-like vasospasm has been proposed as the mechanism for the lesion [3].…”

Section: Discussionmentioning

confidence: 99%

“…Systemic sclerosis (SSc) patients sometimes show various heart diseases, such as conduction system abnormalities, valve abnormalities, and heart failure [1,2], probably due to the Raynaud's phenomenon-like vasospasm of coronary vascular beds and subsequent contraction band necrosis and replacement fibrosis to the endocardium [3], which are also observed in ischemic heart diseases. Myocarditis is frequently observed in cases of SSc accompanying myositis [4,5].…”

Section: Introductionmentioning

confidence: 99%

Systemic sclerosis presented as congestive heart failure: an autopsy case

et al. 2011

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We report the autopsy results of a patient with systemic sclerosis with myositis lesions in the skeletal muscles and myocardium. A 69-year-old Japanese woman developed congestive heart failure and died due to respiratory failure with restrictive hypoventilation. The heart at autopsy showed dilated ventricular hypertrophy, and histopathology of the heart exhibited diffuse replacement fibrosis resembling the lesion of ischemic heart diseases in addition to patchy fibrosis around myocardial fibers suggesting post-myocarditis-like fibrosis.

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“…Myocarditis is more frequent in patient with scleromyositis overlap syndrome than isolated SS. Follansbee et al select 1095 patients with SS to study relationship between CM and skeletal muscle disease [8]. Authors conclude that however myocardial fibrosis was the predominant histological abnormality at autopsy, patients who died in a context of acute myocarditis, have myocytolisis lesion with contraction band necrosis.…”

Section: Commentsmentioning

confidence: 99%

Fatal Myocarditis in a Male with Systemic Sclerosis

Salem¹,

Tougorti²,

Ghorbel³

et al. 2016

J Clin Exp Cardiolog

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Cardiac involvements in systemic sclerosis have a poor outcome. We report here a case of 28 year-old-man with history of systemic sclerosis developing a fatal myocarditis.Initially patient has disabling joint manifestation. Systemic sclerosis is diagnosed after progressive development of cutaneous, pulmonary, and gastrointestinal manifestations. One year after systemic sclerosis diagnosis, our patient develops heart failure signs when he is already treated with methotrexate (15 mg/week) and coticosteroids (15 mg/day). Echocardiography show global hypokinesia with low left ventricular ejection fraction (32%). Natriuretic peptides and troponin levels are high. Anti-centromere and anti-SRP antibodies are positive. Corticosteroids dose is increased to 1 mg/kg/day, and methotrexate was given 25 mg/week without improvement. Cyclophosphamide was started but patient died within six months. Despite immunosuppressive therapy, myocarditis outcome is poor since patient was in heart failure at presentation, and has anti-SRP antibodies.

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Cardiac and skeletal muscle disease in systemic sclerosis (scleroderma): A high risk association

Cited by 192 publications

References 18 publications

Independent Association of Severity of Muscle Weakness With Disability as Measured by the Health Assessment Questionnaire Disability Index in Scleroderma

Independent Association of Severity of Muscle Weakness With Disability as Measured by the Health Assessment Questionnaire Disability Index in Scleroderma

Systemic sclerosis presented as congestive heart failure: an autopsy case

Fatal Myocarditis in a Male with Systemic Sclerosis

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