Cardiac flow velocity in women with the polycystic ovary syndrome

Prelević, Gordana M.; Beijic, Teodora; Balint-Peric, Ljiljana; Ginsburg, Jean

doi:10.1111/j.1365-2265.1995.tb00534.x

Cited by 38 publications

(20 citation statements)

References 23 publications

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“…Also, subclinical impairment of LV systolic and diastolic function as indicated by lower peak strain, peak systolic strain rate, peak early diastolic strain rate, and peak early diastolic velocity was demonstrated in with PCOS and IR group (34). In addition, Prelevic et al (30) reported that systolic flow velocity is lower in PCOS than in age-matched control women, and there is an inverse relationship between serum fasting insulin and LV systolic outflow parameters; fur- thermore, increased insulin levels in PCOS are associated with decreased cardiac flow. In the present study, we found waistto-hip ratio, insulin, HOMA-IR, LDL levels were higher in PCOS group and GLS correlation with the hip-to-waist ratio, LDL values.…”

Section: Discussionmentioning

confidence: 91%

Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study

Erdoğan

Akkaya²,

Bacaksız³

et al. 2013

Anadolu Kardiyol Derg

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Objective: Cardiac involvement has been increasingly recognized in patients with polycystic ovary syndrome (PCOS). Identification of the earliest asymptomatic impairment of left ventricular (LV) performance may be important in preventing progression to overt heart failure. Our aim was to investigate LV function with different echocardiographic techniques in patients with PCOS. Methods: Thirty patients with PCOS and 30 age and body mass index matched healthy subjects were enrolled to this cross-sectional observational study. All subjects underwent echocardiography for assessment of resting LV function as well as two-dimensional speckle tracking echocardiography (2D-STE) and real-time three-dimensional echocardiography (3D-Echo). Global longitudinal strain (GLS) was calculated from 3 standard apical views using 2D-STE. Student t-test, Chi-square test, Pearson's, and Spearman's correlation analysis were used for statistical analysis. Results: The early mitral inflow deceleration time (DT), isovolumetric relaxation time (IVRT) and E/Em ratio were increased in the PCOS group (p<0.05 for all). Waist-to-hip ratio, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and low-density lipoprotein (LDL) levels were higher in PCOS group (p<0.05 for all). Significant correlation was observed between DT, IVRT and insulin value, HOMA-IR (p<0.05 for all). On 3D-Echo evaluation, none of the patients in both groups had LV systolic dysfunction with comparable LV ejection fraction and LV volumes. 2D-STE showed that GLS was significantly reduced in the PCOS group compared to control group (-16.78±0.56% vs. -18.36±1.04%, p<0.001). The GLS was found to be negatively correlated with waist-to-hip ratio and LDL values (p<0.05 for all). Conclusion: These results indicate that PCOS may be related to impaired LV systolic function detected by 2D-STE. In addition, PCOS may lead to diastolic dysfunction. Reduced GLS might be an early indicator of cardiac involvement in this patient population. Original Investigation Özgün Araşt›rma 784ÖZET Amaç: Polikistik over sendromlu (PKOS) hastalarda kardiyak tutulumun olduğu kabul edilmektedir. Asemptomatik sol ventrikül (SV) fonksiyonlarındaki bozulmanın erken tespiti kalp yetersizliğine gidişatın önlenmesinde önemli olabilir. Amacımız PKOS hastalarında farklı ekokardiyografik teknikler kullanarak SV fonksiyonlarını araştırmaktır. Yöntemler: Kesitsel ve gözlemsel calışmamıza, polikistik over sendromlu 30 hasta ve demografik özellikleri benzer 30 sağlıklı kadın dahil edildi. İstirahat SV fonksiyonlarının değerlendirilmesinde standart transtorasik ekokardiyografi yanında, iki boyutlu benek izleme ekokardiyografi (2B-BIE) ve üç boyutlu ekokardiyografi (3B-Eko) bakıldı. SV hacimleri ve ejeksiyon fraksiyonu ölçümü 3B-Eko ile yapıldı. Apikal görüntülerden 2B-BIE tekniği kullanılarak global longitüdinal strain (GLS) değerleri hesaplandı. İstatistiksel analizde; Student t-testi, Ki-kare testi, Pearson ve Spearman korelasyon analizleri kullanıldı. Bulgular: Polikistik over sendr...

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Section: Discussionmentioning

confidence: 91%

Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study

Erdoğan

Akkaya²,

Bacaksız³

et al. 2013

Anadolu Kardiyol Derg

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“…In a study of 26 PCOS patients, a significant negative correlation was observed between the serum fasting insulin concentration and left ventricular systolic outflow parameters. 3) Regardless of the results of the above studies, surprising results have been published on the rates of morbidity and mortality from coronary heart disease in this syndrome. 22,23) In a retrospective study, the hospital records of 786 women with PCOS in the United Kingdom were analysed.…”

Section: Discussionmentioning

confidence: 98%

QT Dispersion in Patients with Polycystic Ovary Syndrome.

et al. 2002

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SUMMARYCardiac risk factors are observed more frequently in patients with polycystic ovary syndrome (PCOS). On the other hand, increased QT dispersion, which is a risk factor for cardiac arrhythmias and sudden death, has not been investigated in this syndrome. In this study, we evaluated QT dispersion in PCOS patients without overt heart disease. Thirtysix consecutive women with PCOS (mean age 24±5 years) and 36 healthy women of similar ages (mean age 24±4 years) participated in this study. PCOS was diagnosed if there were polycystic ovaries by ultrasound (enlarged ovaries with ≥8 cysts 2-8 mm in diameter), oligoamenorrhea (intermenstrual interval >35 days), hirsutism (Ferriman-Gallwey score, ≥7) and elevated serum levels of testosterone (≥2.7 nmol/L). Electrocardiograms were recorded at a paper speed of 50 mm/s. QT intervals were manually measured by a cardiologist. All intervals were corrected for heart rate according to Bazett's formula: QTc interval=QT interval/square root of the RR interval. Mean values of body mass index, heart rate, and blood pressure were not significantly different between the two groups (P>0.05). No significant differences in QT intervals (maximum QT, minimum QT, QT dispersion, minimum corrected QT, maximum corrected QT, and corrected QT dispersion) were observed between the two groups (P>0.05). Our results suggest that the risk of ventricular arrhythmias or sudden cardiac death is not increased in PCOS patients. (Jpn Heart J 2002; 43: 487-493) Key words: Electrocardiography, Polycystic ovary syndrome, QT dispersion POLYCYSTIC ovary syndrome (PCOS) is a disorder of chronic anovulation, hyperandrogenism, hirsutism, obesity, subfertility, hyperlipidemia, and insulin resistance. Infertility is not the only important component of this syndrome, since the risks of cardiac disease and hypertension also increase in women with PCOS.1-3) Insulin resistance and hyperinsulinemia appear central to the pathophysiology of PCOS. Glucose intolerance, abnormally high fasting serum lipid concentrations, and high blood pressure are the three cardiac risk factors that have From the

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“…14 The results of those few studies in vessels outside the pelvis suggest decreased flow over the aortic arch 15 and increased resting forearm flow, and in a previous study we reported lower pulsatility index (vascular resistance) and back pressure, suggestive of reduced vascular tone in the ICA in women with PCOS, 16 whereas asymptomatic women with PCO exhibited similar changes of lesser magnitude. In a recent study, we investigated vascular responses in women with PCOS and observed a paradoxical constrictor response to hypercapnia in the ICA.…”

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confidence: 82%

Impaired Carotid Viscoelastic Properties in Women With Polycystic Ovaries

2002

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Background-The purpose of this study was to assess the elastic properties of the carotid arteries in women with polycystic ovarian syndrome, asymptomatic women with polycystic ovaries, and healthy controls. Methods and Results-We recruited the following 60 subjects: 20 symptomatic women with polycystic ovaries attending the reproductive endocrinology clinics, 20 asymptomatic women with polycystic ovaries attending the family planning clinic, and 20 staff volunteers as healthy controls with normal ovaries on transvaginal scan. Compliance and stiffness index were assessed in the common and internal carotid arteries using duplex ultrasound equipped with an echo-locked arterial wall-tracking system. Compliance was significantly lower in the common carotid artery in symptomatic and asymptomatic women with polycystic ovaries than in the controls (10.7, 14.1, and 19.2 %mm Hg

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Cardiac flow velocity in women with the polycystic ovary syndrome

Abstract: An inverse relation between serum fasting insulin level and left ventricular systolic outflow parameters suggests that insulin is associated with the decreased systolic flow velocity observed in women with PCOS.

Cited by 38 publications

References 23 publications

Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study

Subclinical left ventricular dysfunction in women with polycystic ovary syndrome: an observational study

QT Dispersion in Patients with Polycystic Ovary Syndrome.

Impaired Carotid Viscoelastic Properties in Women With Polycystic Ovaries

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