Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene

Hao, Yilin; Tsuruda, Toshihiro; Sekita-Hatakeyama, Yoko; Kurogi, Syuji; Kubo, Keishi; Sakamoto, Sumiharu; Nakamura, Midori; Udagawa, Nobuyuki; Sekimoto, Tomohisa; Hatakeyama, Kinta; Chosa, Etsuo; Asada, Yujiro; Kïtamura, Kazuo

doi:10.1093/cvr/cvw025

Cited by 26 publications

(19 citation statements)

References 48 publications

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“…Although osteoprotegerin can affect vascular function, its cardiac effects seem to be direct and independent of effects on the vasculature. 94 Recent vascular transcriptomic analysis has shown that the SPHK1 gene (sphingosine phosphate kinase 1) involved in sphingosine-1-phosphate generation is highly affected in hypertensive vasculature in response to angiotensin II 95 . This is important because it seems to modulate NO release, Nox activity, vascular contraction, and inflammation.…”

Section: Inflammatory Mechanisms Of Hypertension Are Linked To Oxidatmentioning

confidence: 99%

Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

2017

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Figure.Central role of oxidative stress in accelerated vascular aging in hypertension. AT1R indicates angiotensin II receptor type 1; BH 2 , dihydrobiopterin; BH 4 , tetrahydrobiopterin; BMP, bone morphogenic protein; CypD, cyclophilin D; eNOS, endothelial NO synthase; ET1R, endothelin 1 receptor; H 2 O 2 , hydrogen peroxide; MMP, matrix metalloproteinase; Nox, NADPH oxidase; O 2 −. , superoxide anion; RANTES, regulated on activation, normal T cell expressed and secreted chemokine; and SmgGDS, GTP-binding protein dissociation stimulator. by guest on

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Section: Inflammatory Mechanisms Of Hypertension Are Linked To Oxidatmentioning

confidence: 99%

Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

2017

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“…Its expression was shown to be increased with age 36 . In animal studies, the OPG-knockout mice not only developed osteoporosis at an early age but also manifested increased apoptotic myocardial cells, cardiac eccentric hypertrophy, attenuated contractile function and artery calcification [37][38][39] . In clinical studies, serum OPG was demonstrated to be positively associated with BMD [40][41][42] , and its expression was reported to be increased in HF patients 43,44 .…”

Section: Discussionmentioning

confidence: 99%

Assessment of the risk of incident heart failure in osteoporosis patients: a systematic review and meta-analysis of eligible cohort studies

Gu¹,

Yang²,

Zhang³

et al. 2020

Polish Archives of Internal Medicine

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only.

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“…The development of transgenic technologies in mice has led to advances in knowledge of the role of OPG/RANKL/RANK system in bone metabolism and cardiometabolic functions. Concerning cardiometabolic disorders, Hao et al[ 84 ] showed that OPG -/- mice exhibited a significant increase in systolic blood pressure since early stages of life, and that this rise was in parallel with the osteoporotic change in these mice. OPG -/- mice also presented a higher heart weight/body weight ratio than age-matched wild-type mice, indicating that OPG plays an important role in the preservation of cardiac structure.…”

Section: Animal Datamentioning

confidence: 99%

Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand axis in nonalcoholic fatty liver disease

Pacifico¹,

Andreoli²,

D'Avanzo³

et al. 2018

WJG

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Concomitantly with the increase in the prevalences of overweight/obesity, nonalcoholic fatty liver disease (NAFLD) has worldwide become the main cause of chronic liver disease in both adults and children. Patients with fatty liver display features of metabolic syndrome (MetS), like insulin resistance (IR), glucose intolerance, hypertension and dyslipidemia. Recently, epidemiological studies have linked obesity, MetS, and NAFLD to decreased bone mineral density and osteoporosis, highlighting an intricate interplay among bone, adipose tissue, and liver. Osteoprotegerin (OPG), an important symbol of the receptor activator of nuclear factor-B ligand/receptor activator of nuclear factor kappa B/OPG system activation, typically considered for its role in bone metabolism, may also play critical roles in the initiation and perpetuation of obesity-related comorbidities. Clinical data have indicated that OPG concentrations are associated with hypertension, left ventricular hypertrophy, vascular calcification, endothelial dysfunction, and severity of liver damage in chronic hepatitis C. Nonetheless, the relationship between circulating OPG and IR as a key feature of MetS as well as between OPG and NAFLD remains uncertain. Thus, the aims of the present review are to provide the existent knowledge on these associations and to discuss briefly the underlying mechanisms linking OPG and NAFLD.

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Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene

Abstract: These results suggest that OPG plays a role in preserving myocardial structure and function with ageing through a reduction in apoptosis and preservation of the matrix structure. In addition, this appears to be independent of effects on the vasculature.

Cited by 26 publications

References 48 publications

Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

Oxidative Stress, Inflammation, and Vascular Aging in Hypertension

Assessment of the risk of incident heart failure in osteoporosis patients: a systematic review and meta-analysis of eligible cohort studies

Role of osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand axis in nonalcoholic fatty liver disease

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