Cardiac impairment in rabbits fed a high-fat diet is counteracted by dehydroepiandrosterone supplementation

The Role of Sex Hormones in Diabetic Retinopathy

“…In a study of rabbits fed a highfat diet, which has been known to increase oxidative stress, Aragno et al found that DHEA restored the rabbits oxidative balance. This supports Brignardello's hypothesis that the protective cellular effect of DHEA is through its antioxidant properties (Aragno et al 2009). Nanomolar concentrations of DHT and E2 had no effect on pericyte loss as a result of high glucose (Brignardello et al 1998).…”

Vascular protective potential of the total flavanol glycosides from Abacopteris penangiana via modulating nuclear transcription factor-κB signaling pathway and oxidative stress

“…High level of circulating MCP-1 can lead to the vascular inflammation via interacting with ox-LDL and finally enhance the proinflammatory state (Toma et al, 2009). Furthermore, the level of NFB is positive correlation with the levels of end-products from lipid peroxidation (Aragno et al, 2009). Lipid peroxidation is a feature of oxidative stress which can produce a degenerative pathway of the membrane components mediated through radicals produced on the cell.…”

“…These inflammatory cytokines are closely related to angiocardiopathy including AS (Eaton et al, 2008). Furthermore, the altered activation of the NFB signaling pathway also associated with the oxidative stress in high glucose-induced aortic pathology (Aragno et al, 2009).…”

“…doi:10.1016/j.jep.2011.04.052 vated of inflammatory cytokines and the generation of oxidized form of low density lipoprotein (ox-LDL) contribute to the pathologic process (Godard et al, 2009;Nagarajan, 2010). The nuclear transcription factor (NF)B signaling pathway is a main feature of the inflammatory responses in oxidative-dependent diabetic aortic pathology (Aragno et al, 2009). The signaling molecule NFB is a proinflammatory major switch that can regulate the efflux of cytokines, such as monocyte chemoattractant protein (MCP)-1 and vascular endothelial growth factor (VEGF) (Wang et al, 2008;Andersson et al, 2010).…”

Dehydroepiandrosterone Protects Endothelial Cells against Inflammatory Events Induced by Urban Particulate Matter and Titanium Dioxide Nanoparticles

“…In rabbits fed with a high-fat diet supplemented with low-dose of DHEA, it showed a partial reduction of oxidative stress restoring the oxidative balance and the inflammatory state, showing a beneficial effect [22]. Besides, pretreatment with sulfated DHEA (DHEAS) reverses the stress-induced changes in behavioral and oxidative stress markers and also brain NOx levels in rats [23].…”