Cardiac morphology and function reference values derived from a large subset of healthy young Caucasian adults by magnetic resonance imaging

Abstract

This is the first large database of reference ranges for ventricular and atrial functions, volumes, and mass in young Caucasian men and women devoid of cardiovascular disease and risk factors. These data will contribute to improving the accuracy of CMR interpretation for clinical and research applications.

Lack of Phenotypic Differences by Cardiovascular Magnetic Resonance Imaging in MYH7 (β-Myosin Heavy Chain)- Versus MYBPC3 (Myosin-Binding Protein C)-Related Hypertrophic Cardiomyopathy

“…13 This is in concordance with the present findings; the average indexed left atrial volume among patients with either mutation was higher than the normal reported values. 37 However, we found no difference in left atrial volume between the 2 genes.…”

Integration of multiple imaging platforms to uncover cardiac defects in adult zebrafish

“…As expected, we observed strong correlations between measurements obtained within the same platform, but also several interesting inter-platform correlations. As seen in humans whose cardiac parameters strongly correlate with gender, age and ethnicity (Lancellotti, 2014;Caballero et al, 2015;Kawel-Boehm et al, 2015;Le Ven et al, 2016;Petersen et al, 2017), we noticed within the WT group a positive correlation between age and the volume of the OFT relative to the entire heart (% OFT volume; Figure 5C). Furthermore, retrograde OFT flow, which was present in two WT animals, correlated with atrial enlargement.…”

Reference values of cardiac ventricular structure and function by steady‐state free‐procession MRI at 3.0T in healthy adult chinese volunteers

“…Differences between the sexes with regard to ventricular parameters has been reported in several studies. 8,14,16,19 Two studies showed no differences between the sexes in LVEDVi, LVESVi, and LVEF after adjustment for BSA. 4,20 Usually, LV and RV volumes are larger in males than in females, even after adjustment for BSA.…”

“…In past decades, several studies have reported the normal reference values of LV or RV volume and function in healthy volunteers or subjects without cardiovascular disease. 9,[12][13][14][15][16][17][18][19] Those results provided useful references for evaluation of the structure and function of the heart. However, most of those studies focused on a single ethnicity and included only narrow age ranges.…”

“…However, most of those studies focused on a single ethnicity and included only narrow age ranges. 12,14,16,20 In the Multi-Ethnic Study of Atherosclerosis (MESA) study, 123 Chinese subjects (15.4% of the total population) were included, which showed LV or RV volumes to be smaller, 7 and indexed parameters to be lower, than those of subjects of European descent. In the present study, the indexed LVEDV, ESV, and mass, as well as RVEDV and ESV, Abbreviation as shown in Table 2.…”