Introduction: The maximum oxygen consumption (VO 2max ) is the gold standard in the cardiorespiratory endurance assessment. Objective: This study aimed to develop a mathematical model that contains variables to determine the VO 2max of sedentary people. Methods: Twenty participants (10 men and 10 women) with a mean age of 19.8±1.77 years were included. For each participant, body composition (percentage of fat and muscle), heart rate variability (HRV) at rest (supine and standing), and VO 2max were evaluated through an indirect test on a cycloergometer. A multivariate linear regression model was developed from the data obtained, and the model assumptions were verified. The obtained model demonstrated the influence exerted by body composition, the autonomic nervous system, and age in the prediction of VO 2max.