Cardiac Rhabdomyomas and Obstructive Left Heart Disease: Histologically but Not Functionally Benign

Black, Michael D.; Kadletz, Margit; Smallhorn, Jeffrey; Freedom, Robert M.

doi:10.1016/s0003-4975(98)00180-5

Cited by 81 publications

(71 citation statements)

References 9 publications

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“…Son benignos y regresan espontáneamente en al menos 54% de los casos, sin embargo, pueden tener indicación quirúrgica si presentan manifestaciones clínicas como compromiso hemodinámico o disrritmia refractaria, síntomas que son más frecuentes en edades tempranas 10,11,17,22 . Se pueden observar desde la época fetal y en este caso suelen ser múltiples en más de 90% de los casos 4,18 .…”

Section: Discussionunclassified

Comportamiento clínico de los tumores cardíacos desde el feto hasta el adulto: serie multicéntrica de 38 pacientes

Borzutzky

et al. 2006

Rev. méd. Chile

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Section: Discussionunclassified

Comportamiento clínico de los tumores cardíacos desde el feto hasta el adulto: serie multicéntrica de 38 pacientes

Borzutzky

et al. 2006

Rev. méd. Chile

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“…Spontaneous tumor resolution is common and treatment is therefore usually conservative. Life threatening complications are unusual, but occasionally surgical resection is necessary (Black et al, 1998).…”

Section: Rhabdomyomamentioning

confidence: 99%

Cardiac tumors in children- A review

Viswanath¹

2014

Int. J. Med. Med. Sci.

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Primary cardiac tumors despite the potential for more frequent recognition with the advent of echocardiography are rare. The incidence of cardiac tumors ranges from 0.0017% to 0.28% in the general population. Primary cardiac tumors are much less common than metastatic tumors of the heart; and of the primary cardiac tumors, over 75% are benign, 3 of which are made up of myxomas, rhabdomyomas and fibromas. The most common primary sites are the lung, breast and cutaneous melanoma. The common malignant tumors are rhabdomyosarcoma and angiosarcoma.

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“…Among them, multiple intracardiac rhabdomyomas can be easily discovered in a newborn with tuberous sclerosis [2]. Intracardiac rhabdomyoma can be subclinical or fatal depending on the onset age, the involving site, and the size and degree of invasion [3,4,5]. Although most rhabdomyomas in early life become smaller with time, emergency intervention is indicated when severe obstruction induces hemodynamic instability [6,7].…”

Section: Introductionmentioning

confidence: 99%

Rapid Regression of Obstructive Cardiac Rhabdomyoma in a Preterm Neonate after Sirolimus Therapy

Lee¹,

Song²,

Cho³

et al. 2017

Biomed Hub

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Cardiac rhabdomyoma can be subclinical or fatal depending on the onset age, involving site, and the size and degree of invasion. Although most rhabdomyomas become smaller with time, emergency intervention is indicated when severe obstruction induces hemodynamic instability. Mammalian target of rapamycin (mTOR) inhibitors have been used to treat neonates and children with hemodynamically obstructive cardiac rhabdomyoma. Herein, we report a premature neonate at the gestational age of 30 + 4 weeks with severe left ventricular outflow tract obstructive cardiac rhabdomyoma who was successfully treated with the mTOR inhibitor sirolimus. To the best of our knowledge, this is the first recorded case of a premature neonate with obstructive cardiac rhabdomyoma who was successfully treated with an mTOR inhibitor. Therefore, sirolimus could be considered as an alternative medical option for managing premature neonates with obstructive cardiac rhabdomyoma.

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Cardiac Rhabdomyomas and Obstructive Left Heart Disease: Histologically but Not Functionally Benign

Cited by 81 publications

References 9 publications

Comportamiento clínico de los tumores cardíacos desde el feto hasta el adulto: serie multicéntrica de 38 pacientes

Comportamiento clínico de los tumores cardíacos desde el feto hasta el adulto: serie multicéntrica de 38 pacientes

Cardiac tumors in children- A review

Rapid Regression of Obstructive Cardiac Rhabdomyoma in a Preterm Neonate after Sirolimus Therapy

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