Cardiac troponin: an emerging cardiac biomarker in animal health

Undhad, V.V.; Fefar, D. T.; Jivani, B. M.; Gupta, Hemlata; Ghodasara, Dineshbhai J.; Joshi, B.P.; Prajapati, Kantibhai S.

doi:10.5455/vetworld.2012.508-511

Cited by 31 publications

(26 citation statements)

References 5 publications

(1 reference statement)

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“…Cardiac troponins (cTn) have a high sensitivity and specificity for myocardial injury. Troponin consists of three subunits: troponin I (cTn-I), troponin T (cTn-T), and troponin C. Troponin T and I are ideal diagnostic markers for myocardial injury since the heart and extracardiac muscle express distinct isoforms which are encoded by different genes (El-Khuffash and Molloy, 2008;Undhad et al, 2012). Owing to the positive correlation between the concentration of troponin and the size of myocardial injury developing after cardiac surgery or cardiotoxic drug treatment, troponin is useful as a prognostic indicator of mortality and morbidity in the paediatric age group.…”

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Cardiac biomarkers in premature calves with respiratory distress syndrome

Aydoğdu

Yıldız

Güzelbekteş

et al. 2016

Acta Veterinaria Hungarica

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The aim of this study was to determine the clinical relevance of cardiac biomarkers [troponin I and T, creatine kinase-MB fraction (CK-MB) and lactate dehydrogenase (LDH)] in premature calves with respiratory distress syndrome. Seventy premature calves were admitted to the clinic within 24 h after birth. Respiratory distress syndrome was diagnosed in premature calves by clinical examination and venous blood gas analysis. Ten healthy calves, aged 5 days, were used as control. Cardiac troponin I and T were analysed using ELISA and ELFA, respectively. Serum CK-MB and LDH were also analysed in an automatic analyser. The calves had low venous pH, pO 2 , O 2 saturation and high pCO 2 values consistent with dyspnoea, hypoxaemia, and inadequate oxygen delivery. Mean serum troponin I, troponin T, CK-MB and LDH levels were increased in the premature calves compared to the control group. In conclusion, the results in this study demonstrated that serum CK-MB, troponin I and troponin T concentrations could be used for evaluating myocardial injury in premature calves with respiratory distress syndrome.

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confidence: 99%

“…Therefore, hypoxia may affect cardiac function. Cardiac biomarkers are used to identify cardiac disease in humans and animals (Undhad et al, 2012;Vijlbrief et al, 2012). Cardiac enzymes including lactate dehydrogenase (LDH) and creatine kinase-MB fraction (CK-MB), as well as troponins are used in the determination of cardiac injury (Kemp et al, 2004).…”

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confidence: 99%

Cardiac biomarkers in premature calves with respiratory distress syndrome

Aydoğdu

Yıldız

Güzelbekteş

et al. 2016

Acta Veterinaria Hungarica

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“…Домрачева, у домашніх тварин серцево-судинна патологія поділяється на хвороби міокарда, перикарда, ендокарда та хвороби кровоносних судин. Існує тісна залежність між вище вказаними патологіями, віком та породами тварин (Stekol'nikov, 2009;Undhad et al, 2012;Zhulikova, 2016).…”

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Determination of acute toxicity of “Bendamin” drug in laboratory animals

Varkholiak

Gutyj

2018

SMLNUVMB

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The study of acute toxicity is a mandatory stage in the investigation of new drugs, which allows assessing the health of substances for health in the short-term and determining the class of toxicity and breadth of therapeutic action. Therefore, at the first stage of the study, the acute toxicity of Bendamin Cardiomatography was studied, in particular the determination of maximum tolerant, toxic and intermittent lethal doses for laboratory animals. The acute toxicity of Bendamin was determined in two stages: indicative and expanded experiments. In the indicative trial, the drug was administered intragastrically at doses of 50, 500 and 5000 mg/kg body weight. Three white mice and rats were used for each dose. In an expanded experiment, Bendamin was administered intragastrically at doses of 5000 and 10000 mg/kg body weight. In determining the acute toxicity of Bendamin, the DL50 value could not be determined, indicating a low toxicity of the test substance. Thus, the DL50 drug for intragastric administration to white mice is greater than 5000 mg/kg m. The general condition of animals in the studied groups did not differ from the state of intact animals: coordination of movements and skeletal muscle tone, pain response, tactile and acoustic stimuli were adequate, the frequency of breathing and the rhythm of heart rate were within the normal range. At administration of the preparation in a dose of 5000 mg/kg m. T, an insignificant inhibition was established, which is related to the introduction of a large amount of the drug. In determining the coefficients of the mass of the internal organs of laboratory animals, a slight decrease in the weight coefficient of the liver was found in both mice and in rats. The "Bendamin" drug when administered to white mice and rats in the stomach in the maximum amount does not cause symptoms of poisoning and behavioral abnormalities. According to GOST 12.1.007-76, Bendamin, for intragastric administration, according to the degree of hazard belongs to grade 4 toxicity -low toxicity substances (DL50 more than 10000 mg/kg body weight). In the future, it is planned to investigate the chronic toxicity and cumulative properties of the drug in laboratory animals.

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“…Estudos realizados com dosagem sérica de cTnT e cTnI, em diferentes espécies de animais indicaram aumento devido a lesões miocárdicas. Doenças cardíacas primárias ou secundarias e o uso de fármacos cardiotóxicos foram reconhecidos como causas de aumento das troponinas (Archer, 2003, Oyama and Solter, 2004, Wallace et al, 2004, Undhad et al, 2012; contudo Alves et al (2015) não constataram alterações no teste cromatográfico qualitativo de Troponina I em cães com cardiopatia crônica.…”

Section: Uso Da Troponina Como Marcador De Doenças Cardíacas Primáriasunclassified

Troponina, biomarcador de injuria cardiaca, en medicina veterinaria: Revisión

Assis

Godoy

Antunes

et al. 2017

Pubvet

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RESUMO.As lesões no miocárdio são de difícil diagnóstico e podem ser confundidas com outras enfermidades, portanto é importante a associação de diferentes métodos de diagnósticos para a conclusão. Na medicina humana as troponinas são reconhecidas, há vários anos, como biomarcadores sensíveis e específicos na identificação de lesões miocárdica. As troponinas são expressas exclusivamente pelo miocárdio e liberadas para circulação logo após uma injúria no músculo cardíaco. Essa revisão aborda os diferentes tipos de troponinas, dando enfoque a sua aplicabilidade e comportamento como marcador de lesão tecidual em animais. Constatou-se se que o uso da troponina I cardíaca (cTnI), como biomarcador de injuria cardíaca, foi validada para o uso diagnóstico em diferentes espécies animais e é capaz de colaborar no diagnóstico e prognóstico das enfermidades miocárdicas, embora, não determinem o mecanismo da lesão. Palavras chave. Animais, biomarcadores, cTnI, isoformas cardíacas, miocárdioTroponin, a cardiac injury biomarker, in veterinary medicine: Review ABSTRACT. Lesions in the myocardium are difficult to diagnose and can be confused with other illnesses, so it is important to combine several diagnostic methods for accuracy. In human medicine, troponins have been recognized for several years as sensitive and specific biomarkers for the identification of myocardial injury. Troponins are exclusively expressed by cardiac myocytes and released into the circulation after an injury to the heart muscle. This review different types of troponins, focusing on their applicability and behavior as a marker of cardiac injury in animals. It was found that the use of cardiac troponin I (cTnI) as a biomarker of cardiac injury has been validated for diagnostic use in several animal species and can assist in diagnosis and prognostication of myocardial diseases though, but does not specify the mechanism of injury.

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Cardiac troponin: an emerging cardiac biomarker in animal health

Cited by 31 publications

References 5 publications

Cardiac biomarkers in premature calves with respiratory distress syndrome

Cardiac biomarkers in premature calves with respiratory distress syndrome

Determination of acute toxicity of “Bendamin” drug in laboratory animals

Troponina, biomarcador de injuria cardiaca, en medicina veterinaria: Revisión

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