Cardiac Troponin I in Feline Hypertrophic Cardiomyopathy

Abstract

Measurement of plasma cardiac troponin I concentration ([cTnI]) is a sensitive and specific means for detecting myocardial damage in many mammalian species. Studies have shown that [cTnI] increases rapidly after cardiomyocyte injury. The molecular structure of cTnl is highly conserved across species, and current assays developed for its detection in humans have been validated in many species. In this study, [cTnI] was quantified using a 2-site sandwich assay in plasma of healthy control cats (n = 33) and cats with moderate to severe hypertrophic cardiomyopathy (HCM) (n = 20). [cTnI] was significantly higher in cats with HCM (median, 0.66 ng/mL; range, 0.05-10.93 ng/mL) as compared with normal cats (median, <0.03 ng/mL; range, <0.03-0.16 ng/mL) (P < .0001). An increase in [cTnI] was also highly sensitive (sensitivity = 85%) and specific (specificity = 97%) for differentiating cats with moderate to severe HCM from normal cats. [cTnI] was weakly correlated with diastolic thickness of the left ventricular free wall (r2 = .354; P = .009) but not with the diastolic thickness of the interventricular septum (P = .8467) or the left atrium: aorta ratio (P = .0652). Furthermore, cats with congestive heart failure at the time of cTnI analysis had a significantly higher [cTnI] than did cats that had never had heart failure and those whose heart failure was controlled at the time of analysis (P = .0095 and P = .0201, respectively). These data indicate that cats with HCM have ongoing myocardial damage. Although the origin of this damage is unknown, it most likely explains the replacement fibrosis that is consistently identified in cats with moderate to severe HCM.

An experimental ovine Theileriosis: The effect of Theileria lestoquardi infection on cardiovascular system in sheep

“…The serum cTnI amounts continued to increase from day 7 after the infection and reached the maximum amount when animals were euthanized. cTnI is considered to be the best biomarker for diagnosis and prognosis of cardiac disorders in animals (Adin et al, 2005;Cornelisse et al, 2000;DeFrancesco et al, 2000;Herndon et al, 2002;Karapinar et al, 2010;O'brien et al, 2006). It seems the elevation of cTnI in the examined sheep was the sign of heart damage in experimental theileriosis.…”

Suspected Bartonella-associated myocarditis and supraventricular tachycardia in a cat

“…Damage to the myocardium can also be evaluated with troponin measurement which has been reported in cats with cardiac disease. 23 However, SVT in humans precipitates an elevated troponin value in the absence of myocardial damage 24,25 ; whether or not this occurs in cats in unclear. Consequently, the clinicians managing this case questioned the diagnostic value of troponin and elected not to have levels measured.…”

Troponina, biomarcador de injuria cardiaca, en medicina veterinaria: Revisión

“…O aumento sérico de cTnT e cTnI também foi associado a quadros de insuficiência cardíaca congestiva, secundária a doença valvular degenerativa, cardiomiopatia dilatada e menor tempo de sobrevivência em cães (DeFrancesco et al, 2002, Oyama andSisson, 2004). A avaliação da cTnI demonstrou sensibilidade de 85% e especificidade de 98% na diferenciação entre felinos saudáveis e portadores de cardiomiopatia hipertrofica (Hemdon et al, 2002). Em equinos, aumento significativo de cTnI foi identificado em cardiomiopatias primárias.…”