Cardio-ankle vascular index predicts for the incidence of cardiovascular events in obese patients: A multicenter prospective cohort study (Japan Obesity and Metabolic Syndrome Study: JOMS)

Satoh‐Asahara, Noriko; Kotani, Kazuhiko; Yamakage, Hajime; Yamada, Tsutomu; Araki, Rika; Okajima, Taiichiro; Adachi, Masahiro; Oishi, Mariko; Shimatsu, Akira

doi:10.1016/j.atherosclerosis.2015.08.003

Cited by 84 publications

(67 citation statements)

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“…These differences are probably due to the study size (144 subjects) and the different ethnic groups of the samples. On the other hand, in a Japanese population, CAVI was shown to be a predictor of cardiovascular events in obese subjects (MetS component) in the Japan Obesity and Metabolic Syndrome study [10]. It should not be forgotten, however, that this is the first study analyzing the association of each MetS component with two arterial stiffness measures and adjustment for different confounding factors in a large simple of subjects at intermediate cardiovascular risk.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, different combinations of MetS components have different effects on arterial stiffness [7–9]. Several studies have also reported that greater arterial stiffness is associated with increased morbidity and mortality from cardiovascular diseases [10–12]. …”

Section: Introductionmentioning

confidence: 99%

“…CAVI is a measure [14] of overall arterial stiffness starting from the aorta all the way to the ankle [16]. It is associated with carotid and coronary atherosclerosis [10, 17–19] and is a predictor of cardiovascular events in the obese [10]. CAVI is a better predictor of coronary artery disease than baPWV [20, 21].…”

Section: Introductionmentioning

confidence: 99%

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Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Gómez‐Sánchez¹,

García‐Ortiz

Patino-Alonso

et al. 2016

Cardiovasc Diabetol

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BackgroundThe cardio-ankle vascular index (CAVI) and brachial-ankle pulse wave velocity (baPWV) can reflect both central and peripheral arterial stiffness. Metabolic syndrome (MetS) and its components may increase arterial stiffness and the risk of cardiovascular diseases. However, the correlation of MetS and its components with arterial stiffness is still not clear. The primary aim of this study is thus the relationship using baPWV and CAVI in Caucasian adults with intermediate cardiovascular risk. The secondary aim is to analyze sex differences.MethodsThis study analyzed 2351 subjects aged 35–74 years (mean, 61.4 ± 7.7 years) comprising 61.7 % males and enrolled in the improving interMediAte Risk management (MARK) study. CAVI was measured using a VaSera VS-1500 ® device, and baPWV was calculated using a validated equation. MetS was defined based on the Joint Scientific Statement National Cholesterol Education Program III. Waist circumference, blood pressure, fasting plasma glucose, and lipid profile were measured.ResultsMetS was found in 51.9 % of the subjects. All MetS components except reduced HDL-cholesterol (p = 0.578) were associated with CAVI. High density lipoprotein cholesterol (p = 0.075) and waist circumference (p = 0.315) were associated with baPWV. The different MetS components that assess dyslipidemia using the stiffness measures show different associations according to patient sex. The high blood pressure component had a greater odds ratio (OR) for both baPWV ≥ 17.5 m/sec (OR = 6.90, 95 % CI 3.52–13.519) and CAVI ≥ 9 (OR = 2.20, 95 % CI 1.63–1.90).ConclusionsMetS and all its components (except HDL-cholesterol with baPWV and CAVI and WC with baPWV) were associated with baPWV and CAVI. However, there were sex differences in the association of MetS and its components with baPWV and CAVI. Data from this study suggest a greater association of CAVI and baPWV values with MetS components in males than in females and indicate greater arterial stiffness in the event of simultaneously elevated blood pressure, fasting plasma glucose, and waist circumference. Trial Registration Clinical Trials.gov Identifier: https://clinicaltrials.gov/ct2/show/ NCT01428934. Registered 2 September 2011. Last updated September 8, 2016Electronic supplementary materialThe online version of this article (doi:10.1186/s12933-016-0465-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Gómez‐Sánchez¹,

García‐Ortiz

Patino-Alonso

et al. 2016

Cardiovasc Diabetol

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“…Satoh-Asahara et al 55) reported that CAVI could predict the outcome following a 5-year period of cardiovascular diseases in obese patients (n 425). High CAVI was one of the significant prognostic factors for the cardiovascular events in Cox stepwise multivariate analysis when adjusted for age and sex [CAVI (per 1): hazard ratio, 1.44 (1.02-2.02), p 0.037).…”

Section: (A) Calcium Channel Blockersmentioning

confidence: 99%

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Saiki

Sato

Watanabe

et al. 2016

J Atheroscler Thromb

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Measurement of arterial stiffness in routine medical practice is important to assess the progression of arteriosclerosis. So far, many parameters have been proposed to quantitatively represent arterial stiffness. Among these, pulse wave velocity (PWV) has been most frequently applied to clinical medicine because those could be measured simply and non-invasively. PWV had established the usefulness of measuring arterial wall stiffness. However, PWV essentially depends on blood pressure at the time of measurement. Therefore, PWV is not appropriate as a parameter for the evaluation of arterial stiffness, particularly for the studies involving blood pressure changes.On the other hand, stiffness parameter is an index reflecting arterial stiffness without the influence of blood pressure. Recently, this parameter has been applied to develop a new arterial stiffness index called cardio-ankle vascular index (CAVI). Therefore, CAVI does not depend on blood pressure changes during the measurements; CAVI could represent the stiffness of the arterial tree from the origin of the aorta to the ankle.Many clinical studies obtained from CAVI are being accumulated. CAVI showed high value in arteriosclerotic diseases, such as coronary artery diseases, cerebral infarction, and chronic kidney diseases, and also in majority of people with various coronary risk factors. The improvement of those risk factors decreased CAVI. Furthermore, the role of CAVI as a predictor of cardio-vascular events was reported recently.We review the clinical studies on CAVI and discuss the clinical usefulness of CAVI as a candidate surrogate end-point marker for cardiovascular disease.

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“…20 On the other hand, Kato et al reported that CAVI was not a predictor of cardiovascular events in patients on regular hemodialysis. 21 However, those previous studies were based on limited populations.…”

Section: Disclosures / Names Of Grant Supportmentioning

confidence: 99%

Clinical Impact of the Cardio-Ankle Vascular Index for Predicting Cardiovascular Events After Acute Coronary Syndrome

Gohbara

Iwahashi

Sano

et al. 2016

Circ J

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Cardio-ankle vascular index predicts for the incidence of cardiovascular events in obese patients: A multicenter prospective cohort study (Japan Obesity and Metabolic Syndrome Study: JOMS)

Cited by 84 publications

References 47 publications

Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

Association of metabolic syndrome and its components with arterial stiffness in Caucasian subjects of the MARK study: a cross-sectional trial

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Clinical Impact of the Cardio-Ankle Vascular Index for Predicting Cardiovascular Events After Acute Coronary Syndrome

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