Cardiomyopathy as One of the Less Frequent Manifestations of Takayasu’s Arteritis

Abstract

Summary:The authors present the case of a young woman with newly diagnosed Takayasu's arteritis. This woman, with arterial hypertension, was investigated for the unspecific symptoms at the beginning. Afterwards, the transthoracic echocardiography showed dysfunction of the left ventricle and the abdominal sonography showed a stenosis of the right renal artery. PET/CT scan showed chronic modification after inflammatory processes on the wall of the thoracic and abdominal aorta. This case report should be instructive to other clinicians and refers to the necessity to remember this rare disease in our country too.

Dilated Cardiomyopathy Being the Presenting Manifestation of Takayasu Arteritis and Treated With Renal Angioplasty

“…In some cases there may be no improvement in LV function. 2,4 Corticosteroids in high doses are the primary treatment recommended for TA. 1 Cytotoxic therapy, like methotrexate, cyclophosphamide, and mycophenolate mofetil, is recommended for those patients that are resistant to glucocorticoid treatment.…”

“…It leads to segmental stenosis, occlusion, dilatation, or aneurysm formation. 4 It is predominantly a disease of young females in their second and third decades. Although this disorder is more frequent in Asians, it occurs worldwide and no race seems to be immune.…”

“…These patients often have arterial hypertension, which is frequently associated with renal artery stenosis. 4 The laboratory data usually includes findings that are indicative of generalized inflammation, with mild leukocytosis and anemia, elevation of the C-reactive protein, thrombocytosis, and elevation of erythrocyte sedimentation. 5 Other laboratory data for connective tissue disorder (ANA, rheumatoid factor, antineutrophil cytoplasmic antibodies, etc) are very often within normal limits.…”

“…1 Cytotoxic therapy, like methotrexate, cyclophosphamide, and mycophenolate mofetil, is recommended for those patients that are resistant to glucocorticoid treatment. 4 Antihypertensive and decongestive therapies are given to patients with heart failure and systemic hypertension, usually with good response. Renovascular hypertension responds poorly to drug therapy.…”

Arterial Hypertension in Systemic Vasculitis: Clinical Features and Principles of Pathogenetic Therapy. Part I. Clinical, Diagnostic and Pathogenetic Aspects

“…Де-монстративным в данном отношении является одно из наблюдений польских исследователей, когда именно повышение АД на правой руке у 16-летней девушки, выявленное во время профилактического осмотра, явилось отправной точкой при формировании диаг-ностической концепции артериита Такаясу [33]. Ана-логические ситуации изложены в публикациях и дру-гих авторов [34,35]. При этом АГ, развивающаяся в де-бюте СВ, нередко приобретает черты злокачественной [36][37][38][39].…”