Cardioprotection with resveratrol pretreatment: improved beneficial effects over standard treatment in rat hearts after global ischemia

Abstract

The findings from this study indicate that RVT has potent cardioprotective properties against I/R injury in rat hearts. The study also highlighted that the administration of RVT, as pretreatment, has amplified the beneficial effects over the standard treatment.

Effects of resveratrol and methylprednisolone on biochemical, neurobehavioral and histopathological recovery after experimental spinal cord injury

“…The production of ROS can lead to cell injury through cell membrane lipid destruction and can diffuse intracellularly and cause mitochondrial enzyme damage and cleavage of DNA [43,44] . Recently, resveratrol was found to be a highly potent antioxidant that could inhibit free radical generation in the brain, spinal cord, heart, kidney, liver, red cell membrane, and so on [19,36,[44][45][46][47][48][49] . It has been shown that it inhibits lipid peroxidation [50] , and prevents apoptotic cell death induced by oxidative stress [51,52] .…”

The effect of leptin and resveratrol on JAK/STAT pathways and Sirt-1 gene expression in the renal tissue of ischemia/reperfusion induced rats

“…Our previous studies reported that leptin has a protective effect on renal I/R model induced by 1 hour of ischemia following 1 hour of reperfusion (1). Another study showed the protective effects of resveratrol against oxidative stress on cardiac I/R model in the same time periods (2). Smith et al investigated the role of the JAK/STAT pathway in the cardioprotective effects of resveratrol and suggested that the effects may involve leptin-induced STAT3 phosphorylation (3).…”

“…Smith et al investigated the role of the JAK/STAT pathway in the cardioprotective effects of resveratrol and suggested that the effects may involve leptin-induced STAT3 phosphorylation (3). Resveratrol, a natural polyphenol compound, has many biochemical and physiological effects, including anti-infl ammatory, antioxidant, antiapoptotic and antiproliferative effects (2). Recent studies have suggested that resveratrol may protect against ischemic damage in skeletal muscle, heart and brain (2,4).…”

“…Resveratrol, a natural polyphenol compound, has many biochemical and physiological effects, including anti-infl ammatory, antioxidant, antiapoptotic and antiproliferative effects (2). Recent studies have suggested that resveratrol may protect against ischemic damage in skeletal muscle, heart and brain (2,4). Nevertheless, the molecular mechanisms of resveratrol action are not yet clarifi ed.…”

Why research on resveratrol-mediated cardioprotection should not decelerate1This editorial was invited by the Editors.

“…Several ex-vivo studies using isolated perfused hearts subjected to ischemia-reperfusion have reported resveratrol-mediated resistance to myocardial injury (Hung et al 2002;Dernek et al 2004;Mokni et al 2007;Xi et al 2009). These ex-vivo findings have been corroborated in an in-vivo study using an experimental model of acute ischemia-reperfusion injury (Shen et al 2006).…”