Cardioprotective effect of caffeic acid phenethyl ester on cardiac contusion following blunt chest trauma in rats

BIÇAKÇI, Nurcan; Karaboğa, İhsan; Dökmeci, Ayşe Handan; Güzel, Savaş; Erboğa, Zeynep Fidanol

doi:10.1080/10520295.2019.1586999

Cited by 11 publications

(5 citation statements)

References 31 publications

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“…The latter leads, among other effects, to increasing inflammatory signals, hypertrophy of cardiomyocytes, and proliferation and synthesis of extracellular matrix components, such as collagen and fibronectin [32,33]. Caffeic acid has also shown anti-inflammatory [34] and cardioprotective properties decreasing cardiomyocyte damage and apoptosis [35]. In our study, losartan, dihydrocaffeic acid and GGN1231 reduced the cardiomyocytes' size, but only the latter decreased wall thickness.…”

Section: Discussionmentioning

confidence: 44%

Effects of a Losartan-Antioxidant Hybrid (GGN1231) on Vascular and Cardiac Health in an Experimental Model of Chronic Renal Failure

Martínez-Arias

Fernández-Villabrille

Alonso-Montes

et al. 2023

Nutrients

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Drugs providing antihypertensive and protective cardiovascular actions are of clinical interest in controlling cardiovascular events and slowing the progression of kidney disease. We studied the effect of a hybrid compound, GGN1231 (derived from losartan in which a powerful antioxidant was attached), on the prevention of cardiovascular damage, cardiac hypertrophy, and fibrosis in a rat model of severe chronic renal failure (CRF). CRF by a 7/8 nephrectomy was carried out in male Wistar rats fed with a diet rich in phosphorous (0.9%) and normal calcium (0.6%) for a period of 12 weeks until sacrifice. In week 8, rats were randomized in five groups receiving different drugs including dihydrocaffeic acid as antioxidant (Aox), losartan (Los), dihydrocaffeic acid+losartan (Aox+Los) and GGN1231 as follows: Group 1 (CRF+vehicle group), Group 2 (CRF+Aox group), Group 3 (CRF+Los group), Group 4 (CRF+Aox+Los group), and Group 5 (CRF+GGN1231 group). Group 5, the CRF+GGN1231 group, displayed reduced proteinuria, aortic TNF-α, blood pressure, LV wall thickness, diameter of the cardiomyocytes, ATR1, cardiac TNF-α and fibrosis, cardiac collagen I, and TGF-β1 expression. A non-significant 20% reduction in the mortality was also observed. This study showed the possible advantages of GGN1231, which could help in the management of cardiovascular and inflammatory processes. Further research is needed to confirm and even expand the positive aspects of this compound.

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Section: Discussionmentioning

confidence: 44%

Effects of a Losartan-Antioxidant Hybrid (GGN1231) on Vascular and Cardiac Health in an Experimental Model of Chronic Renal Failure

Martínez-Arias

Fernández-Villabrille

Alonso-Montes

et al. 2023

Nutrients

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“…[ 36 ] In the studies carried out on cardiac contusion induced by blunt trauma, TP I and CK-MB levels have been revealed to increase when compared to the HG. [ 37 ] In our study, it was observed that administering contusion caused an increase in TP I and CK-MB levels. Our findings supported the occurrence of cardiomyocyte damage in accordance with the literature.…”

Section: Discussionmentioning

confidence: 57%

The effect of rutin on experimentally induced acute heart contusion in rats. Biochemical and histopathological evaluation

Elma¹

2021

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: Acute cardiac contusion induced by trauma is known with its high mortality and morbidity. The role of oxidative stress and inflammation in its pathophysiology has led to the investigation of antioxidant and anti-inflammatory substances in non-surgical treatment. In this study, the effects of rutin which has these two features on acute cardiac contusion were investigated. METHODS: Thirty male albino Wistar rats were divided into three equal groups as healthy (HG), contusion (CG), and rutin + contusion (rutin + CG). A heart contusion was created dropping 200 g weight from 1-m height onto anterior thorax of CG (n=10) and Rutin + CG (n=10) group animals by anesthetizing with intraperitoneal administration of 60 mg/kg ketamine and xylazine inhalation at appropriate intervals. Thirty minutes after contusion was applied, rutin at the dose of 50 mg/kg was administered orally to the stomach by gavage to the rutin + CG group animals. The rutin was used once a day for 2 days. Rats were killed at the end of 48 h. Heart tissues were removed and examined biochemically and histopathologically. Troponin I (TP I) and creatine kinase-MB (CK-MB) were measured in blood samples taken from the tail veins just before the rats were killed. RESULTS: TP I, CK-MB, malondialdehyde, total oxidant status, and nuclear factor-kappa B levels increased in the CG when compared to the HG, and Rutin application prevented this increase, total glutathione (eGSH) and total antioxidant status levels decreased, and rutin application prevented this decrease. Histopathological findings also supported these findings. CONCLUSION: Rutin had a protective effect on heart tissue.

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“…Several different mediators are released in the organism as a result of cardiac injury. Recent studies in humans [45] and experimental animals [46] have shown that cytokines and chemokines such as TNF-α and IL-6 increase after trauma-induced injury. It is an important and reliable indicator that IL-6 and TNF-α measurement in the 1 st h of the trauma helps in determining the severity of the trauma.…”

Section: Acıpayam Et Al Effects Of Amifostine In Cardiac Injury In Ratsmentioning

confidence: 99%

Effects of Amifostine against Blunt Chest Trauma-Induced Cardiac Injury in Rats

Acıpayam¹

2023

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:This study aimed to examine whether two different doses of dexamethasone (DXM), which is a corticosteroid, and amifostine (AMI), which reduces cumulative tissue toxicity induced by cisplatin in advanced-stage cancer patients, have ameliorative effects on pathologic changes associated with cardiac contusion (CC) induced in rats. METHODS:Forty-two Wistar albino rats were equally divided into six groups (n=7): C, CC, CC+AMI 400, CC+AMI 200, CC+AMI+DXM, and CC+DXM. Tomography images and electrocardiographic analyzes were performed, mean arterial pressure was measured from the carotid artery, and blood and tissue samples were obtained for histopathological and biochemical analyses after trauma-induced CC. RESULTS:While the total oxidant status and disulfide parameters in the cardiac tissue and serum were significantly higher (p<0.05), the total antioxidant status, total thiol, and native thiol parameters were significantly lower (p<0.01) in rats with trauma-induced CC. The most frequently observed finding in the electrocardiography analyze was ST elevation. CONCLUSION:According to evaluation based on histological, biochemical, and electrocardiographic examinations, we believe that only 400 mg/kg dose of AMI or DXM can be effective in the treatment of myocardial contusion in rats. Evaluation based on histological findings.

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Cardioprotective effect of caffeic acid phenethyl ester on cardiac contusion following blunt chest trauma in rats

Cited by 11 publications

References 31 publications

Effects of a Losartan-Antioxidant Hybrid (GGN1231) on Vascular and Cardiac Health in an Experimental Model of Chronic Renal Failure

Effects of a Losartan-Antioxidant Hybrid (GGN1231) on Vascular and Cardiac Health in an Experimental Model of Chronic Renal Failure

The effect of rutin on experimentally induced acute heart contusion in rats. Biochemical and histopathological evaluation

Effects of Amifostine against Blunt Chest Trauma-Induced Cardiac Injury in Rats

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