Cardioprotective Effect of Mexiletine in Acute Myocardial Ischemia. Studies in the Rabbit Closed Chest Ischemia Model.

Orally Administered Benidipine and Manidipine Prevent Ischemia - Reperfusion Injury in the Rat Heart

“…There have been some reports explaining the mechanism, such as that the effects are expressed via bradykinin-and nitric oxide-dependent pathways, the action of ATP-sensitive K + channels, ATP storage in the myocardium before ischemia, the suppression of the myocardial oxygen requirement before ischemia and so on. [28][29][30][31][32] In our study, calcium antagonists were effective for cardioprotection, but it is unclear how they act. We assessed the relationship between the LVDP after 60 min of reperfusion and the rate -pressure product immediately before the global ischemia (Fig 3), but there was no correlation between the rate -pressure product before the ischemic insult and the post-ischemic contractile function because the cardiac performance improved largely without pre-ischemic depression of the heart at the optimal dose and the function at higher dosages fell off remarkably.…”

Clinical and Electrocardiographic Characteristics of Electrical Storms Due to Monomorphic Ventricular Tachycardia Refractory to Intravenous Amiodarone

“…KATP openers protect myocardial cells from ischemia-induced and reperfusion-induced injury by preventing calcium overload during ischemia. 26 Our results may be applicable to oral therapy. Several researchers have reported that a combination of oral antiarrhythmic drugs used empirically in patients and the complementary actions of class I and class III agents were effective.…”

Mexiletine as one effective alternative for antiarrhythmic drugs and ablation resistant electrical storm - A case report

“…Moreover, cardioprotective effect of mexiletine was also described. It might be due to opening of adenosine triphosphate--sensitive potassium channels, thus preventing calcium overload and leading to protection against both ischemia-and reperfusion-injury [20].…”