Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury

Wang, Dong; Guo, Xin; Zhou, Mingjie; Han, Jing; Han, Bo; Sun, Xiling

doi:10.1155/2014/368376

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…Beneficial effects of NAC on ischemic injury of the human and rabbit hearts have been previously reported [54] . Also, the other antioxidants (lavender flower and tribulosin) showed cardioprotective effects by means of reduced levels of myocardial injury markers in CVE during ischemia-reperfusion injury [65] , [73] , respectively). Furthermore, it is obvious that levels of CK and LDH did not change following global ischemia of any durations comparing to control values.…”

Section: Discussionmentioning

confidence: 97%

The effects of N -acetylcysteine on cisplatin-induced cardiotoxicity on isolated rat hearts after short-term global ischemia

et al. 2015

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The aim of this study was to estimate the protective effect of N-acetyl-l-cysteine (NAC) against cisplatin-induced cardiotoxicity under conditions of ischemic-reperfusion injury.Wistar albino rats were randomly divided into three groups (n = 8): control, cisplatin (5 mg/kg/w, i.p., 5 weeks) and cisplatin + NAC group (cisplatin – 5 mg/kg/w, i.p. and NAC – 500 mg/kg/w, i.p., 5 weeks). Isolated hearts were perfused according to the modified Langendorff technique at constant pressure (70 cmH2O). Following cardiodynamic parameters were measured: maximum rate of left ventricular pressure development, minimum rate of left ventricular pressure development, left ventricular systolic pressure (SLVP), left ventricular diastolic pressure and heart rate. The ischemic vasodilation episodes were induced by the complete interruption of coronary inflow for 30, 60 and 120 s. The samples of the coronary venous effluent (CVE) were continuously collected during the reperfusion period for determination of coronary flow (CF) rate and oxidative stress markers (H2O2, O2−, NO2− and thiobarbituric acid reactive substances – TBARS).Cisplatin reduced CF, heart rate and overflow (total, maximal and duration of overflow) during reperfusion, and increased SLVP (under basal conditions and after global ischemias). Cisplatin increased levels of H2O2 (under basal conditions), O2− and TBARS (under basal conditions and after ischemia), but decreased NO2− levels (during reperfusion) in CVE, and decreased superoxide dismutase and reduced glutathione in serum. NAC attenuated cisplatin-induced changes of cardiodynamic parameters (except CF under basal conditions) and oxidative stress parameters.Those results suggest that NAC, by decreasing oxidative stress, may be useful in cardioprotection during cisplatin therapy.

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Section: Discussionmentioning

confidence: 97%

The effects of N -acetylcysteine on cisplatin-induced cardiotoxicity on isolated rat hearts after short-term global ischemia

et al. 2015

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“…Augmentation of endogenous antioxidants (SOD, CAT, thiol) has been recognized as an important pharmacological property, present in natural as well as many synthetic compounds like vitamin C. 39 , 40 This constitutes a major mechanism of protection against oxidative stress, offered by them. 41 , 42 The most abundant ROS generated in living system is superoxide radical which is acted upon by SOD to produce hydrogen peroxide which in turn is inactivated by catalase into water and oxygen.…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effects of Achillea wilhelmsii on the isolated rat heart in ischemia–reperfusion

Mahmoudabady

Lashkari

Soukhtanloo

2017

Journal of Traditional and Complementary Medicine

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ContextThere are some reports about protective effects of Achillea on the heart.ObjectiveWe investigated the effect of Achillea wilhelmsii extract on cardiac function during ischemia–reperfusion (I/R) injury in the isolated rat heart.Materials and methods60 male Wistar rats were randomly divided into 6 groups; 1: Control group, 2: Control-ischemia (CI) 3: vitamin C (10 mg/kg), 4–6: Extract groups (E 100, E 200 and E 400 mg/kg). The animals received normal saline, vitamin C or A. wilhelmsii extract orally for 4 weeks. At the end of the treatment, the hearts were subjected to in vitro I/R Injury (20 min of global ischemia, followed by 40 min of reperfusion, Langendorff's mode). Heart rate (HR) and left ventricular pressure (LVP) were measured using a pressure transducer connected to a data acquisition system. Lactate dehydrogenase (LDH) and creatine kinase (CK) activities in the effluent were measured to determine the myocardial injury degree. The malondialdehyde (MDA), total thiol groups (-SH), superoxide anion dismutase (SOD) and catalase (CAT) in myocardial tissue were detected to determine the oxidative stress degree.ResultsPretreatment with Achillea wilhlemsii significantly decreased the LDH, CK activities, and MDA level, while it increased the LVDP, ±dp/dtmax, rate-pressure product (RPP), SH groups, SOD and CAT activities, and also the coronary artery flow.Discussion and conclusionOur findings indicated that Achillea wilhelmsii could provide protection for heart against the I/R injury which may be related to the improvement of myocardial oxidative stress states.

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“…Clinical studies also support the antihypertensive effects of lavender aromatherapy (Hwang, 2006;Gultom et al, 2016). Both linalool and lavender essential oil/ extract have exerted cardioprotective effects in experimental models of myocardial ischemia and reperfusion injury (Wang et al, 2014;Ziaee et al, 2015;Zheng et al, 2017). The activation of Akt and the inhibition of GSK3b through the up-regulation of VEGF-B mRNA are suggested as potential pathways for linalool's cardioprotective effects (Zheng et al, 2017).…”

Section: Introductionmentioning

confidence: 95%

Anti‐Arrhythmic Effects of Linalool via Cx43 Expression in a Rat Model of Myocardial Infarction

Zhu

Zhang

et al. 2020

Front. Pharmacol.

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Background: Lavender is a traditional therapy for different heart symptoms including palpitation, which comprises an important symptom of cardiac arrhythmias. This experiment was designed to evaluate the antiarrhythmic effects of linalool using an experimental model of arrhythmia following myocardial infarction in rats. The underlying electrophysiological mechanism through cardiac connexin 43 (Cx43) expression was also investigated. Methods: Fifty male Sprague-Dawley rats were divided into five equal groups. The first group was considered as the normal control group; MI was induced by ligation of the left anterior descending artery (LAD) in the second group. The other three groups received metoprolol (100 mg/kg/day) or linalool (50 or 100 mg/kg/day) for seven days before LAD ligation. The arrhythmia score, isolated myocyte resting potential, histological changes, and cardiac Cx43 expression levels were evaluated. Results: In the MI group, there was a significant increase in the arrhythmia score but a marked decrease in resting membrane potential relative to the control; these changes were prevented by the administration of metoprolol or linalool. The histological changes were also minimized in the groups treated with these substances compared to the untreated MI group. The western blot and real-time PCR results showed that the protein expression of Cx43 in the infarct zone of the rat hearts was significantly higher in the MI groups receiving metoprolol or linalool compared with the untreated MI group. Conclusion: Linalool was shown to be able to dose-dependently decrease the incidence of arrhythmias in a rat model of myocardial infarction. We propose that the key mechanism behind this antiarrhythmic effect is probably the prevention of decreased Cx43 expression following MI.

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Cardioprotective Effect of the Aqueous Extract of Lavender Flower against Myocardial Ischemia/Reperfusion Injury

Cited by 7 publications

References 21 publications

The effects of N -acetylcysteine on cisplatin-induced cardiotoxicity on isolated rat hearts after short-term global ischemia

The effects of N -acetylcysteine on cisplatin-induced cardiotoxicity on isolated rat hearts after short-term global ischemia

Cardioprotective effects of Achillea wilhelmsii on the isolated rat heart in ischemia–reperfusion

Anti‐Arrhythmic Effects of Linalool via Cx43 Expression in a Rat Model of Myocardial Infarction

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