Cardioprotective effects of hesperidin on carbon monoxide poisoned in rats

Rezaee, Ramin; Sheidary, Alireza; Jangjoo, Saeedeh; Ekhtiary, Sarvenaz; Bagheri, Somayeh; Kohkan, Zahra; Dadres, Madjid; Docea, Anca Oana; Tsarouhas, Konstantinos; Sarigiannis, D; Karakitsios, Spyros; Tsatsakis, Aristidis; Kovatsi, Leda; Hashemzaei, Mahmoud

doi:10.1080/01480545.2019.1650753

Cited by 35 publications

(12 citation statements)

References 44 publications

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“…Administration of hesperidin decreased the expression of zinc finger E-box binding homeobox 2 (ZEB2, a transcription factor that binds to specific regions of DNA) by upregulating the expression of miRNA-132, which in turn promoted apoptosis and inhibited the proliferation of non-small cell lung cancer cells in mice [79]. Citrus peel extracts have been proven to be a promising therapeutic agent for diabetes mellitus, characterized by defects in insulin metabolism that can alter carbohydrate, protein and fat metabolism [2,4,80,81]. A review of the literature indicates that obesity is connected with insulin resistance and pancreatic β-cell dysfunction [82,83].…”

Section: Biological Activitiesmentioning

confidence: 99%

Hesperidin: A Review on Extraction Methods, Stability and Biological Activities

Pyrzyńska

2022

Nutrients

134

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Hesperidin is a bioflavonoid occurring in high concentrations in citrus fruits. Its use has been associated with a great number of health benefits, including antioxidant, antibacterial, antimicrobial, anti-inflammatory and anticarcinogenic properties. The food industry uses large quantities of citrus fruit, especially for the production of juice. It results in the accumulation of huge amounts of by-products such as peels, seeds, cell and membrane residues, which are also a good source of hesperidin. Thus, its extraction from these by-products has attracted considerable scientific interest with aim to use as natural antioxidants. In this review, the extraction and determination methods for quantification of hesperidin in fruits and by-products are presented and discussed as well as its stability and biological activities.

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Section: Biological Activitiesmentioning

confidence: 99%

Hesperidin: A Review on Extraction Methods, Stability and Biological Activities

Pyrzyńska

2022

Nutrients

134

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“…Several intervention studies have investigated the cardiovascular protective effects of citrus flavonoid [ 48 ] and various berries, including Euterpe oleracea [ 49 , 50 ]. The results from these studies suggest a positive impact of berry consumption.…”

Section: Discussionmentioning

confidence: 99%

Myorelaxation, respiratory depression and electrocardiographic changes caused by the administration of extract of açai (Euterpe oleracea Mart.) stone in rats

Muto

Hamoy²,

Lucas

et al. 2021

Toxicology Reports

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“…Further, hesperidin prevented the slow inactivation phase of I Na (54). According to reports , hesperidin reduces cardiac necrosis (55). Protein kinase B (Akt ) expression was improved in animals treated with hesperidin (100 mg/kg), while the apoptosis regulator (BAX/BCL2) market ratio declined substantially.…”

Section: The Role Of Anti-oxidants In the Management Of Cardiac Arrhymentioning

confidence: 97%

“…Irrespective of hesperidin administration, electrocardiogram ECG improvements were reversed in groups 2 hours after carbon monoxide CO exposure. In general, hesperidin minimized the detrimental cardiac effects of CO toxicity in rats (55). Table 2 sets out the anti-arrhythmic effects of other flavonoids.…”

Section: The Role Of Anti-oxidants In the Management Of Cardiac Arrhymentioning

confidence: 99%

The role of flavonoids in the prevention and management of cardiovascular complications: a narrative review

Chen¹,

Zhang²

2021

Ann Palliat Med

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Objective: Cardiovascular diseases (CVDs) are the world's leading cause of death, affecting an estimated 17.9 million people. CVDs have been the primary risk factor for mortality in developed countries. Smoking, hypertension, diabetes, abdominal obesity, psychological stressors, insufficient vegetable and fruit intake could significantly alleviate the burden of disease. The present review sought to document the antihypertensive, anti-arrhythmic, anti-anginal, and anti-infarction effects of flavonoids.Background: Cardiovascular disorders are the leading cause of death worldwide, affecting an estimated 17.9 million individuals. Strokes and heart attacks account for 4 out of every 5 deaths caused by cardiovascular disorders. Physical activity protects against a variety of chronic conditions at any age. A demographic program combined with a high-risk CVD prevention approach could dramatically minimize the disease burden in the coming years. By controlling weight and improving the body's use of insulin, physical activity decreases the risk of CVDs. Tobacco and smoking are other modifiable factors associated with the progression of cardiovascular disorders. Abnormal blood lipids are also linked to dietary habits.Daily flavonoid consumption is linked to a lower risk of heart disease. Flavonoids have been the subject of significant interest by experts in recent times due to wide spectrum of possible benefits they provide. polyphenolic compounds can be useful as adjunctive therapy for the management and cure of inflammatory diseases.Methods: Literature related to cardiovascular effects of flavonoids was assessed on important database like PubMed, Scopus, ScienceDirect. The outcomes of various studies were documented.Conclusions: Flavonoids are fairly soluble in physiological media and thus are a potential candidate for the possible management of cardiovascular and associated disorders. Alleviating the oxidative stress induced by reactive oxygen species using anti-oxidant-rich flavonoids could lower the chances of platelet hyperactivation, heart disease, discomfort, and fibrosis. Flavonoid intake on a daily basis has been linked to a lower risk of heart failure. Polyphenolic compounds have the ability to be used as an adjunctive therapy in the prevention and control of cardiovascular and inflammatory diseases. Flavonoids have a role in the management of coagulation disorders.

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Cardioprotective effects of hesperidin on carbon monoxide poisoned in rats

Cited by 35 publications

References 44 publications

Hesperidin: A Review on Extraction Methods, Stability and Biological Activities

Hesperidin: A Review on Extraction Methods, Stability and Biological Activities

Myorelaxation, respiratory depression and electrocardiographic changes caused by the administration of extract of açai (Euterpe oleracea Mart.) stone in rats

The role of flavonoids in the prevention and management of cardiovascular complications: a narrative review

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