Myorelaxation, respiratory depression and electrocardiographic changes caused by the administration of extract of açai (Euterpe oleracea Mart.) stone in rats

Muto, Nilton Akio; Hamoy, Moisés; Lucas, David Cristian Rodrigues; Teixeira, Bruno José Brito; Almeida, Adrielle Felicia Santos; Navegantes, Thamires de Castro; Sá, Vaniza de Sousa Ferreira de Sheila; Moraes, Brenda Pinto de; Medeiros, João Paulo do Vale; Santos, Yasmin Amorim dos; Rocha, Cláudia Quintino da; Mello, Vanessa Jóia de; Rogez, Hervé

doi:10.1016/j.toxrep.2021.03.024

Cited by 7 publications

(11 citation statements)

References 48 publications

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“…We used the EEOS solution from açai stones in our study, as previously described ( Muto et al, 2021 ). In short, after pulping açai fruits, 100 g of açai stones was washed and dried at 105°C for 24 h. Stones were ground (16 mesh), shaken with 200 mL of ethanol for 2 h, and macerated at 4°C for 10 days in dark bottles.…”

Section: Methodsmentioning

confidence: 99%

“…The phytochemistry profile of EEOS was previously determined by the colorimetric method (total phenolic compounds, flavanols, flavonols, and proanthocyanidins) as well as by liquid chromatographic analysis (LC-ESI-IT-MS/MS) ( Muto et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

“…Although açai stones are not edible its high antioxidant capacity has been studied for new applications through the treatment of diabetes and lung cancer ( De Bem et al, 2018 ; Martinez et al, 2018 ). Extracts of Euterpe oleracea stone (EEOS) analyzed through HPLC/MS exhibited high levels of polyphenols such as caffeic acid, procyanidin, catechin, polymeric proanthocyanidins, and cinnamtannin, followed by traces of other phenolic compounds ( Muto et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, it has been shown that Euterpe oleracea pulp exhibits antiepileptic properties in mice and benefits the metabolism of patients with diabetes associated with hypertension ( Souza-Monteiro et al, 2015 ; De Bem et al, 2018 ). Furthermore, our previous results demonstrated that EEOS has strong sedative and myorelaxant effects similar to benzodiazepine-based drugs (BDZs) ( Muto et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

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Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor

Muto

Hamoy

Ferreira

et al. 2022

Front. Cell. Neurosci.

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Epilepsy is one of the most common neurological diseases globally, resulting from a disorder in brain activity. This condition can be triggered by birth trauma, traumatic brain injury (TBI), infections of the brain and stroke. More than 70 million people suffer seizures caused by neurological abnormalities. Approximately 80% of all epileptic patients reside in low-income conditions or in developing countries, and over 75% of patients do not receive proper treatment. Our previous study found an anticonvulsant property of an extract of Euterpe oleracea stone (EEOS) that caused myorelaxation, sedation, and cardiac and respiratory depression after intraperitoneal administration. The present study investigated through electroencephalographic (EEG) profiling the anticonvulsant protective properties of EEOS in induced convulsing rats. Male Wistar rats were treated with EEOS (300 mg/kg), diazepam (DZP) (5 mg/kg), pentylenetetrazol (PTZ) (60 mg/kg) and flumazenil (FMZ) (0.1 mg/kg) by intraperitoneal (i.p.). Electrodes implanted on the dura mater provided EEG data in which EEOS suppressed seizure deflagration caused by PTZ. In addition, EEOS presented no significant difference in comparison to DZP, which has the same mechanism of action. After FMZ injection, a GABAA receptor antagonist blocked the anticonvulsive effect in both the DZP and EEOS groups, suggesting that EEOS exerts it action on the GABAA receptor at the benzodiazepine (BDZ) subunit.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor

Muto

Hamoy

Ferreira

et al. 2022

Front. Cell. Neurosci.

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“…All animals received 2.5 mg/kg of diazepam intraperitoneally to prevent movement and noise in the registers. Each record was made at lasted 3 min for each animal and the analyzed data were heart rate (bpm), amplitude (mV), RR interval (ms), PQ interval (ms), QRS duration (ms) and QT interval (ms) ( 28 ).…”

Section: Methodsmentioning

confidence: 99%

100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats

Lima

Silva

Azevedo

et al. 2022

Endocrine Connections

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Low plasma levels of vitamin D causes bone mineral change that can precipitate osteopenia and osteoporosis, and could aggravate autoimmune diseases, hypertension and diabetes. The demand for vitamin D supplementation becomes necessary; however, the consumption of vitamin D is not without risks, which its toxicity could have potentially serious consequences related to hypervitaminosis D, such as hypercalcemia and cerebral alterations. Thus, the present study describes the electroencephalographic changes caused by supraphysiological doses of vitamin D in the brain electrical dynamics, and the electrocardiographic changes. After 4 days of treatment with vitamin D at dose of 25,000 IU/Kg, the serum calcium levels found was increased in comparison with control group. The ECoG analysis found a reduction in wave activity in the delta, theta, alpha and beta frequency bands. For ECG was observed changes with shortened QT follow-up, which could be related to serum calcium concentration. This study presented important evidence about the cerebral and cardiac alterations caused by high doses of vitamin D, indicating valuable parameters in the screening and decision-making process for diagnosing patients with symptoms suggestive of intoxication.

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Potentiation of the depressant effect of alcohol by flunitrazepam in rats: an electrocorticographic, respiratory and electrocardiographic study

Freitas,

Amaral,

Conceição

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Myorelaxation, respiratory depression and electrocardiographic changes caused by the administration of extract of açai (Euterpe oleracea Mart.) stone in rats

Abstract: Graphical abstract

Cited by 7 publications

References 48 publications

Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor

Extract of Euterpe oleracea Martius Stone Presents Anticonvulsive Activity via the GABAA Receptor

100 YEARS OF VITAMIN D: Supraphysiological doses of vitamin D changes brainwave activity patterns in rats

Potentiation of the depressant effect of alcohol by flunitrazepam in rats: an electrocorticographic, respiratory and electrocardiographic study

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