Cardiorespiratory fitness predicts cardiovascular health in breast cancer survivors, independent of body composition, age and time post-treatment completion

Jones, Lynnette M.; Stoner, Lee; Brown, Casey; Baldi, James C.; McLaren, Blair

doi:10.1007/s12282-019-00975-2

Cited by 10 publications

(10 citation statements)

References 40 publications

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“…Until now, no scientific results have been available to support the use of rowing as an activity to improve cardiac function in BC survivors, although literature exists on cardiac function in BC survivors who engage in dragon boat training and other exercise modalities [37,[51][52][53][54][55][56]. The most striking results of these studies are the significant improvement in diastolic function after four years of dragon boat training [51] together with the work of Serra et al [52] whose findings revealed a 5% reduction in systolic and diastolic blood pressure in female BC survivors after a 16-week resistance training program while our research obtained twice the reductions for these same variables, a total of 10% with four fewer weeks of treatment.…”

Section: Discussionmentioning

confidence: 99%

“…According to the National Cancer Institute, certain treatments can damage the heart and the circulatory system leading to a series of side effects, such as hypertension, abnormal heart rhythm and heart failure, which are generally caused or exacerbated by chemotherapy and radiotherapy [50]. No studies currently exist that analyze how rowing affects heart function and blood pressure in BC survivors, but there are several articles showing that physical exercise improves these functions [37,[51][52][53][54][55][56]. Notable among them is the study by Stefani et al [51] which reports that BC survivors who received chemotherapy treatment experienced a significant improvement in diastolic function measurements after four years of dragon boat training, increasing by 2.5 cm/s.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac Effects of a Rowing Training Program in Breast Cancer Survivors

et al. 2021

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The aim of this study was to determine whether a rowing training program could improve cardiac function in women (n = 28) with the mean age of 52.30 ± 3.78 years who survived breast cancer (stage 1: 4.55%; 2: 36.36%; 3: 54.54%; and 4: 4.55%) diagnosed 4.68 ± 3.00 years previously and underwent subsequent surgery (preservation: 56.52%; total mastectomy: 39.13%; and double mastectomy: 4.35%). Participants completed a 12-week training program consisting of three weekly sessions lasting 60–90 min with a progressive intensity increase according to the Börg scale. The assessments performed were blood pressure and pulse measurements both at rest and after performing the six-minute walk test to collect data on cardiac behavior and aerobic performance. The results showed statistically significant differences in cardiovascular system efficiency measured on the basis of heart rate both before (−12.63 ± 14.68 bpm) and after the six-minute walk test (−11.46 ± 28.39 bpm), increase in the distance achieved in the aerobic endurance test (51.56 ± 48.26 m) as well as decrease in diastolic (−13.6 ± 7.85 mm Hg) and systolic (−6.60 ± 9.10 mm Hg) blood pressure. These results suggest that rowing training programs could be a strategy to consider in this population for the benefits observed in heart rate, blood pressure and aerobic performance, which would lead to improved general health and quality of life.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiac Effects of a Rowing Training Program in Breast Cancer Survivors

et al. 2021

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“…Weight changes have also shown a strong correlation with autonomic functioning, with weight gain being linked to sympathetic activation and weight loss related to improvements in parasympathetic activity and heart rate recovery (HRR) [2]. Breast cancer patients tend to gain weight, with increases of 2 to 6 kg common in women undergoing chemotherapy [58]. In fact, it is known that this modest weight gain in non-obese patients can potentiate SNS activation, regardless of whether they become obese [59].…”

Section: Additional Mechanisms Leading To Autonomic Dysfunction In Br...mentioning

confidence: 99%

Cardiovascular Dysautonomia in Patients with Breast Cancer

Geraldes¹,

Caldeira²,

Afonso³

et al. 2022

TOCMJ

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Breast cancer is the most frequent malignant disease among women, being responsible for a considerable percentage of fatalities and comorbidities every year. Despite advances in early detection and therapy, evidence shows that breast cancer survivors are at increased risk of developing other chronic conditions, such as cardiovascular diseases. Autonomic dysfunction is an emerging, but poorly understood topic that has been suggested as a risk factor for cardiovascular disease in breast cancer patients. It clinically manifests through persistently elevated heart rates and abnormal heart rate variability, even before any signs of cardiovascular dysfunction appear. Since changes in the left ventricular ejection fraction only manifest when myocardial injury has already occurred, it has been hypothesized that autonomic dysfunction can constitute an early biomarker of cardiovascular impairment in breast cancer patients. This review focuses on the direct and indirect effects of cancer and its treatment on the autonomic nervous system in breast cancer patients. We highlight the mechanisms potentially involved in cancer and antineoplastic therapy-related autonomic imbalance and review the potential strategies to prevent and/or attenuate autonomic dysfunction. There are gaps in the current knowledge; more research in this area is needed to identify the relevance of autonomic dysfunction and define beneficial interventions to prevent cardiovascular disease in breast cancer patients.

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“…Using submaximal exercise is a well-established practice for assessment of older individuals and individuals with a history of chronic conditions, such as cancer. 17,18 Previously published studies support the efficacy of aerobic exercise prescription in improving cardiorespiratory fitness among cancer survivors post-treatment. 19 However, less is known regarding the benefits of a combined aerobic and resistance training (CART) intervention among cancer survivors on cardiorespiratory fitness.…”

Section: Introductionmentioning

confidence: 99%

Heart Rate Variability and Cardiovascular Adaptations Among Cancer-Survivors Following a 26-Week Exercise Intervention

et al. 2020

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Cardiotoxicity as a result of cancer treatment contributes to autonomic dysfunction and decreased cardiorespiratory fitness among cancer survivors. These deleterious cardiovascular outcomes reduce the survival prognosis for cancer patients and contribute to poor quality of life among survivors. Exercise interventions have been shown as effective in mitigating treatment-related side effects. However, previously published interventions have not explored the potential for improvement in autonomic dysfunction (heart rate variability, HRV). This study examined cardiovascular adaptations in cancer survivors (n = 76) who participated in a 26-week intervention consisting of combined aerobic and resistance training (CART). The most noteworthy improvements occurred during the first 13 weeks of training and were maintained throughout the end of the 26-week period. HRrest improved from baseline (PRE) to the midpoint (MID) ( P = .036) and from PRE to POST timepoints ( P = .029). HRV and VO2max did not initially appear to change in response to CART. However, after stratification on time since treatment, participants who were 5 or more years from their last treatment experienced improvements (ie increase) in the HRV characteristic of HF power ( P = .050) and also in VO2max ( P =.043), when compared to those experiencing less than 5 years of time since their last treatment. These findings highlight a need for more attention to address the cardiorespiratory deficits experienced by those who have recently completed cancer treatment. In conclusion, the CART intervention is effective in improving cardiorespiratory fitness and autonomic dysfunction. The structure of the intervention is feasible for cancer survivors to continue with at home, using minimal resources, and without supervision. This at-home model may be even more acceptable to recent survivors that may be homebound immediately following treatment.

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Cardiorespiratory fitness predicts cardiovascular health in breast cancer survivors, independent of body composition, age and time post-treatment completion

Cited by 10 publications

References 40 publications

Cardiac Effects of a Rowing Training Program in Breast Cancer Survivors

Cardiac Effects of a Rowing Training Program in Breast Cancer Survivors

Cardiovascular Dysautonomia in Patients with Breast Cancer

Heart Rate Variability and Cardiovascular Adaptations Among Cancer-Survivors Following a 26-Week Exercise Intervention

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