Cardiotoxicity of some pesticides and their amelioration

El‐Nahhal, Yasser; El-Nahhal, Ibrahim

doi:10.1007/s11356-021-14999-9

Cited by 38 publications

(19 citation statements)

References 277 publications

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“…The different pathologies accumulated throughout life could also have predisposed twin brother 1 to a susceptibility to carbofuran intoxications. This hypothesis is supported by (i) literature data reporting cardiotoxicity of carbofuran [31] and (ii) a pathological aspect of the heart (hypertrophic cardiomyopathy) of twin brother 1 observed during autopsy, although we have no similar data for twin brother 2.…”

Section: Discussionsupporting

confidence: 60%

Carbofuran self-poisoning: forensic and analytic investigations in twins and literature review

et al. 2022

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Discussionsupporting

confidence: 60%

Carbofuran self-poisoning: forensic and analytic investigations in twins and literature review

et al. 2022

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“…Cardiotoxicity is the alteration, injury, and/or dysfunction of the heart that may develop following drug, heavy metal, pesticide, or toxicant exposure. Various mechanisms have been suggested for chemicals‐induced cardiotoxicity, including apoptosis induction, cytokines release, ROS generation, and suppression of the antioxidant system (El‐Nahhal & El‐Nahhal, 2021 ; Zhang, Zhu, et al, 2019 ). Due to its anti‐inflammatory, antiapoptosis, and antioxidant properties, rutin may have the potential to alleviate some of the cardiotoxicity caused by such agents (Table 3 ).…”

Section: Methodsmentioning

confidence: 99%

The protective effects of rutin on the liver, kidneys, and heart by counteracting organ toxicity caused by synthetic and natural compounds

Rahmani

Naraki

Roohbakhsh

et al. 2022

Food Science & Nutrition

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Rutin is a flavonoid present in many plant species. Because of its antioxidant, anti‐inflammatory, and antiapoptotic properties, rutin is of interest for its potential protective effects against toxic agents. The hepatoprotective, renoprotective, and cardioprotective effects of rutin are reviewed. The antioxidant effects of rutin are elicited by enhancing antioxidant enzymes such as GST, GGT, CAT, GPx, SOD, and GR, activating the Nrf2/HO‐1 pathway, elevating GSH content, and the reduction in MDA. The anti‐inflammatory effects of rutin are mediated by the inhibition of IL‐1β, IL‐6, TGF‐β1, COX‐2, iNOS, TLR4, and XO. Rutin exerted its antiapoptotic effects by inhibition of free radicals, caspase‐3/‐7/‐9, hsp70, HMGB1, and p53, and the elevation of the antiapoptotic protein Bcl‐2. Rutin has potential therapeutic effectiveness against several toxicants, and its beneficial effects are more than likely mediated by its antioxidant, anti‐inflammatory, and/or antiapoptotic property.

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“…At this time, biological monitoring technology has come into being, and the use of indicator organisms for water quality detection is in line with the requirements of the public. Among them, it is feasible to monitor water pollution by using the regeneration ability of planarians [28] [29] [30] [31]. The past research showed D. japonica was a wonderful biological indicator to detect water pollution [32] [33] [34] [35].…”

Section: Challenges and Future Prospectsmentioning

confidence: 99%

Application of Planarian Brain Regeneration: Detection of Water Pollution

Kang¹,

Xiao²,

Yin³

et al. 2023

OJE

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Due to over industrialisation, the environmental pollution problem is becoming increasingly serious, especially in aquatic ecosystems. Compared with traditional physical and chemical detection methods, the use of biological indicators has become popular. The freshwater planarian Dugesia japonica is distributed extensively in aquatic ecosystems and has been applied to the area of environmental toxicology for its high chemical sensitivity. Moreover, D. japonica also has a powerful regenerative capability in which the injured planarian can regenerate a new brain in 5 days and complete an adult individual remodelling in 14 days. Therefore, it has been used as a new model organism in the field of neuro-regeneration toxicology. In our past study, D. japonica can be used as a biological indicator to detect water pollution. This can provide basic data for the detection of water pollution and provide a warning system in regard to aquatic ecosystems.

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Cardiotoxicity of some pesticides and their amelioration

Cited by 38 publications

References 277 publications

Carbofuran self-poisoning: forensic and analytic investigations in twins and literature review

Carbofuran self-poisoning: forensic and analytic investigations in twins and literature review

The protective effects of rutin on the liver, kidneys, and heart by counteracting organ toxicity caused by synthetic and natural compounds

Application of Planarian Brain Regeneration: Detection of Water Pollution

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