Cardiovascular Actions of Sodium Nitroprusside in Animals and Hypertensive Patients

Page, Irvine H.; Corcoran, A. C.; Dustan, Harriet P.; Koppanyi, Theodore

doi:10.1161/01.cir.11.2.188

Cited by 242 publications

(91 citation statements)

References 5 publications

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“…onset of nitroprusside infusion in normal animals (13,23,25) and humans (27) as well as in hypertensive individuals (4,23). This response is probably a result of baroreceptor response to the reduced arterial blood pressure.…”

Section: Discussionmentioning

confidence: 99%

Effects of Nitroprusside on Cardiac Function, Blood Flow Distribution, and Oxygen Consumption in the Conscious Young Lamb

et al. 1984

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Section: Discussionmentioning

confidence: 99%

Effects of Nitroprusside on Cardiac Function, Blood Flow Distribution, and Oxygen Consumption in the Conscious Young Lamb

et al. 1984

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“…Nitroprusside relaxes arterial and venous smooth muscle 25 without effects on other types of smooth muscle or myocardial contractility. 26,27 Vasodilatory actions of NTP may occur, in part through interactions with the sympathetic nervous system, but are not dependent on any specific adrenergic receptor or ganglion.…”

Section: Mechanisms Of Ntp-induced Hyperemiamentioning

confidence: 99%

Coronary Hyperemic Dose Responses of Intracoronary Sodium Nitroprusside

Parham¹,

Bouhasin²,

Ciaramita³

et al. 2004

Circulation

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Background-Sodium nitroprusside is one of several agents considered effective for treating the no-reflow phenomenon during acute coronary interventions. However, the coronary hyperemic dose responses and systemic hemodynamic effects of intracoronary nitroprusside have yet to be determined in humans. The purpose of this study was to compare the hyperemic and hemodynamic responses of intracoronary nitroprusside to intracoronary adenosine in patients during cardiac catheterization with angiographically normal anterior descending arteries. Methods and Results-In 21 patients, coronary blood flow velocity (0.014-inch Doppler flow wire), heart rate, and blood pressure were measured in unobstructed left anterior descending coronary arteries at rest, after intracoronary adenosine (30-to 50-g boluses), and after 3 serial doses (0.3-, 0.6-, and 0.9-g/kg boluses) of intracoronary nitroprusside. Coronary reserve was calculated as hyperemia/basal coronary flow velocity. In an additional 9 patients with intermediate stenoses (53Ϯ7%), 14 fractional flow reserve (FFR) measurements (using 0.014-inch pressure wire) were performed with both intracoronary adenosine and nitroprusside (0.6 g/kg). Intracoronary nitroprusside produced equivalent coronary hyperemia with a longer duration (Ϸ25%) compared with intracoronary adenosine. Intracoronary nitroprusside (0.9 g/kg) decreased systolic blood pressure by Ͻ20%, with minimal change in heart rate, whereas intracoronary adenosine had no effect on these parameters. FFR measurements with intracoronary nitroprusside were identical to those obtained with intracoronary adenosine (rϭ0.97). Conclusions-Compared with adenosine, intracoronary nitroprusside produces an equivalent but more prolonged coronary hyperemic response in normal coronary arteries. Intracoronary nitroprusside, in doses commonly used for the treatment of the no-reflow phenomenon, can produce sustained coronary hyperemia without detrimental systemic hemodynamics. On the basis of FFR measurements compared with adenosine, sodium nitroprusside also appears to be a suitable hyperemic stimulus for coronary physiological measurements.

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“…Thus, drugs that release nitric oxide, including sodium nitroprusside (24) , may enhance leishmanicidal activity in macrophages. The pharmacological characteristics of these drugs were established in 1955 (25) , and clinical application has since widened (26) (27) . Indeed, sodium nitroprusside remains in use due to its effectiveness and rapid action (26) (28) , despite reports of cyanide toxicity.…”

Section: Discussionmentioning

confidence: 99%