Cardiovascular Complications of Cancer Therapy

Chang, Hui-Ming; Okwuosa, Tochukwu; Scarabelli, Tiziano M.; Moudgil, Rohit; Yeh, Edward T.H.

doi:10.1016/j.jacc.2017.09.1095

Cited by 245 publications

(127 citation statements)

References 150 publications

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“…Besides, long-term chemotherapeutic toxicity results in cardiac diseases and may trigger secondary cancer such as marrow neoplasm or leukemia [36,37]. Chemotherapy-linked cardiotoxicity is another major setback of cancer therapy that increases the mortality rate because of the high prevalence of cardiovascular diseases in cancer patients [38].…”

Section: Chemotherapeutic-associated Toxicity In Breast Cancer Treatmentmentioning

confidence: 99%

Herbal Remedies for Breast Cancer Prevention and Treatment

Laskar¹,

Lourembam²,

Mazumder³

2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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Breast cancer is among the most common type of cancer in women around the globe. Prevention of breast cancer is better than its treatment. Because of the molecular variation and complexity underlying breast cancer occurrence, its treatment by using chemotherapy and/or radiotherapy is very complicated and often leads to undesirable side effects. Plants and their extracts have been used for centuries for the treatment of almost every disease and breast cancer is not an exception. Herbal products can be trusted for cancer treatment because of their low toxicity. Besides, herbal remedies are easily accepted by the majority of woman suffering from breast cancer because of their easy availability and affordability. In the last decade, a large number of plants and their compounds were reported to show promising anticancerous effects against breast cancer cells in both in vivo and in vitro models. However, their beneficial effects on breast cancer treatment are still doubtful due to the lack of randomized clinical trials. This chapter is dedicated to reporting the potential of some herbal products for the prevention and/or treatment of breast cancer. Besides, it focused on the anticarcinogenic mechanism of those phytocompounds to report their potential chemotherapeutic role.

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Section: Chemotherapeutic-associated Toxicity In Breast Cancer Treatmentmentioning

confidence: 99%

Herbal Remedies for Breast Cancer Prevention and Treatment

Laskar¹,

Lourembam²,

Mazumder³

2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

View full text Add to dashboard Cite

show abstract

“…Antall med avrundet prosentandel i parentes der annet ikke er oppgitt. Medikamentell kreftbehandling er forbundet med økt risiko for kardiovaskulaere tilstander, både akutt og som ledd i senskader (13,14). Det at hele 43 % i vårt materiale hadde etablert kardiovaskulaer sykdom allerede ved førstegangskonsultasjonen, tilsier at det er behov for å forebygge slike komplikasjoner og at en del pasienter sannsynligvis vil kunne profittere på systematisk samarbeid mellom onkologer og kardiologer.…”

Section: Tabellunclassified

Sårbarhetsfaktorer hos eldre med kreft

Berg¹,

Rostoft²

2019

Tidsskriftet

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“…Cancers 2020, 12, 704 4 of 24 Cardiac complications represent unresolved and potentially life-threatening conditions in cancer survivors, thus compromising some favorable benefits of modern cancer treatments and, consequently, representing a challenge for clinicians and patients [17]. Early detection and prevention of cardiotoxicity, as well as understanding of the multifactorial interaction among the selected chemotherapeutic regimen, traditional cardiovascular risk factors and individual susceptibility are urgently needed to optimize treatment options and reduce cardiotoxicity [18]. In response to ongoing clinical challenges, recently, personalized medicine and the new interdisciplinary area of cardio-oncology, focusing on the diagnosis, prevention, and management of cardiovascular complications associated with the treatment of malignancy, have been useful in developing new safer therapeutic strategies [17].…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs in Cancer Treatment-Induced Cardiotoxicity

Pellegrini

Sileno

D'agostino

et al. 2020

Cancers

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Cancer treatment has made significant progress in the cure of different types of tumors. Nevertheless, its clinical use is limited by unwanted cardiotoxicity. Aside from the conventional chemotherapy approaches, even the most newly developed, i.e., molecularly targeted therapy and immunotherapy, exhibit a similar frequency and severity of toxicities that range from subclinical ventricular dysfunction to severe cardiomyopathy and, ultimately, congestive heart failure. Specific mechanisms leading to cardiotoxicity still remain to be elucidated. For instance, oxidative stress and DNA damage are considered key players in mediating cardiotoxicity in different treatments. microRNAs (miRNAs) act as key regulators in cell proliferation, cell death, apoptosis, and cell differentiation. Their dysregulation has been associated with adverse cardiac remodeling and toxicity. This review provides an overview of the cardiotoxicity induced by different oncologic treatments and potential miRNAs involved in this effect that could be used as possible therapeutic targets.Cancers 2020, 12, 704 2 of 24 circulating miRNAs have been used as excellent biomarkers in different studies and can be used as biomarkers for cardiovascular diseases (CVDs) [5]. Moreover, miRNA deregulation is often associated with tumor progression, and many anticancer treatments affect miRNA expression. In this review we aimed to discuss relevant miRNAs modulated by therapies for cancer that have been demonstrated to be involved in CVD. In the following paragraphs, we provide an overview of the most important anticancer treatments that are known to induce cardiotoxicity. Anticancer Treatment and CardiotoxicityAnticancer treatment has accomplished remarkable progress in the last century resulting in improved quality of life and survival rates of cancer patients. These advances in cancer treatment, however, have been often accompanied by therapy-related complications, including secondary side effects on the whole organism [6].The most commonly used cancer therapeutics in modern medicine include the traditional surgery, radiotherapy, and conventional chemotherapy approaches; moreover, two new therapeutic modalities have been introduced in recent decades, namely molecularly targeted therapy and immunotherapy [7], as summarized in Figure 1. Traditional chemotherapy agents consist of non-specific cytotoxic treatments (e.g., alkylating agents and antimetabolites) that rapidly eliminate replicating cells, including not only tumor cells but also normal tissue cells, with a broad range of side effects that significantly limit their applications in cancer therapy. In contrast to conventional systemic chemotherapy, molecularly targeted cancer therapies, using novel drugs aimed at the inhibition of intracellular signaling pathways fundamental for cancer proliferation or differentiation (e.g., monoclonal antibodies and low molecular weight protein-kinase inhibitors), are thought to be cancer-specific, with fewer associated adverse effects on normal cells [8]. Lastly, immunother...

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Cardiovascular Complications of Cancer Therapy

Cited by 245 publications

References 150 publications

Herbal Remedies for Breast Cancer Prevention and Treatment

Herbal Remedies for Breast Cancer Prevention and Treatment

Sårbarhetsfaktorer hos eldre med kreft

MicroRNAs in Cancer Treatment-Induced Cardiotoxicity

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