BackgroundCharacterizing electronic cigarette (eācigarette) use patterns is important for guiding tobacco regulatory policy and projecting the future burden of tobaccoārelated diseases. Few studies have examined patterns of eācigarette use in individuals with cardiovascular disease (CVD).Methods and ResultsWe examined eācigarette use in adults aged 18 to 89Ā years with a history of CVD, using data from the 2014 National Health Interview Survey. We investigated associations between ever and current eācigarette use and smoking with multivariable logistic regression. In a secondary analysis, we modeled the association between eācigarette use and a quit attempt over the past year. Former smokers with CVD who quit smoking within the past year showed 1.85 (95% confidence interval, 1.03, 3.33) times the odds of having ever used eācigarettes as compared with those who reported being āsome daysā current smokers. Current smokers who attempted to quit smoking within the past year showed significantly increased odds of ever having used eācigarettes (odds ratio, 1.70; 95% confidence interval, 1.25, 2.30) and currently using eācigarettes (odds ratio, 1.97; 95% confidence interval, 1.32, 2.95) as compared with smokers who had not attempted to quit over the past year.ConclusionsIndividuals with CVD who recently quit smoking or reported a recent quit attempt were significantly more likely to use eācigarettes than current smokers and those who did not report a quit attempt. Our findings may indicate that this population is using eācigarettes as an aid to smoking cessation. Characterizing emerging eācigarette use behaviors in adults with CVD may help to inform outreach activities aimed at this highārisk population.