Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis

Snel, Gert J. H.; Boomen, Maaike van den; Hernández, Luís; Nguyen, Christopher; Sosnovik, David E.; Velthuis, Birgitta K.; Slart, Riemer H. J. A.; Borra, Ronald; Prakken, Niek H J

doi:10.1186/s12968-020-00627-x

Cited by 25 publications

(33 citation statements)

References 201 publications

(363 reference statements)

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“…There is also a lack of understanding of how these changes in parameters affect T2 or T2* measurements. Reported T2 and T2* values in healthy subjects showed large variation between centres which could be explained due to the acquisition standardisation 18 . While the literature highlighted some guidelines for use of protocols for T2* measurements for cardiovascular image 19 , different acquisition approaches were implemented for T2 sequences and hence lead to variations in T2 values 20 .…”

Section: Introductionmentioning

confidence: 99%

Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients

Ahmed¹,

Baldo²,

Sulieman

et al. 2021

Sci Rep

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This work aimed to investigate the effect of different shim techniques, voxel sizes, and repetition time (TR) on using theT2 and T2* sequences to determine their optimum settings to investigate the quantification of iron in transfused dependent sickle cell patients. The effect of each of these parameters was investigated on phantoms of different Gadolinium (Gd) concentrations, on 10 volunteers and 25 patients using a1 5T MRI Philips scanner. No significant difference between the three shim techniques was noticed in either T2 or T2* sequence measurements. Pixel sizes of 1 × 1 and 2 × 2 mm provided optimum results for T2 measurements. At 1 × 1 mm pixel size the T2* measurements experienced less error in measurements than the size of 2.5 × 2.5 mm used in the literature. Even though the slice thickness variation did not provide any changes in T2 measurements, the 12 mm provided optimum T2* measurements. TR variation did not yield significant changes on either T2 or T2* measurements. These results indicate that both T2 and T2* sequences can be further improved by providing more reliable measurements and reducing acquisition time.

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Section: Introductionmentioning

confidence: 99%

Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients

Ahmed¹,

Baldo²,

Sulieman

et al. 2021

Sci Rep

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“…In 2015, a 3D T2 mapping sequence was developed [9] and subsequently evaluated for the detection of the focal hotspots of myocardial injury, specifically those related to ACAR [10]. While the results of the DRAGET trial are pending, a number of studies on multiparametric CMR in HTx were published recently [11][12][13]. Vermes reported that using a combination of a T2 (>57,7 ms) and ECV (>32%) cut-off values for ACAR detection could have prevented 63% of routine biopsies [11].…”

Section: Resultsmentioning

confidence: 99%

Cardiac magnetic resonance imaging with T2 mapping for the monitoring of acute heart transplant rejection in patients with problematic endomyocardial biopsy: in anticipation of new recommendations

Dorniak

Stopczyńska

Heeswijk³

et al. 2021

Kardiol Pol

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“…Therefore, the assessment of institution-specific reference ranges with established scanner- and sequence-specific T 2 values in healthy volunteers are strongly recommended ( 2 ). With scanner- and sequence-specific reference values as a prerequisite, it was demonstrated that T 2 values in studies of specific inflammatory conditions such as myocarditis ( 3 ), systemic sclerosis ( 37 ), and sarcoidosis ( 35 ) can unequivocally be used to identify myocardial injury. Therefore, the significant difference in T 2 relaxation time that was found in patients using the 3D but not the 2D T 2 mapping merits special attention, as this might suggest better sensitivity to detect tissue alterations with the proposed high-resolution motion-registered radial 3D T 2 mapping technique at 1.5T.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Motion-Registered Isotropic Whole-Heart T2 Mapping in Patients With Acute Non-ischemic Myocardial Injury

Dorniak

Sopra

Sabisz

et al. 2021

Front. Cardiovasc. Med.

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Background: T2 mapping is a magnetic resonance imaging technique that can be used to detect myocardial edema and inflammation. However, the focal nature of myocardial inflammation may render conventional 2D approaches suboptimal and make whole-heart isotropic 3D mapping desirable. While self-navigated 3D radial T2 mapping has been demonstrated to work well at a magnetic field strength of 3T, it results in too noisy maps at 1.5T. We therefore implemented a novel respiratory motion-resolved compressed-sensing reconstruction in order to improve the 3D T2 mapping precision and accuracy at 1.5T, and tested this in a heterogeneous patient cohort.Materials and Methods: Nine healthy volunteers and 25 consecutive patients with suspected acute non-ischemic myocardial injury (sarcoidosis, n = 19; systemic sclerosis, n = 2; acute graft rejection, n = 2, and myocarditis, n = 2) were included. The free-breathing T2 maps were acquired as three ECG-triggered T2-prepared 3D radial volumes. A respiratory motion-resolved reconstruction was followed by image registration of the respiratory states and pixel-wise T2 mapping. The resulting 3D maps were compared to routine 2D T2 maps. The T2 values of segments with and without late gadolinium enhancement (LGE) were compared in patients.Results: In the healthy volunteers, the myocardial T2 values obtained with the 2D and 3D techniques were similar (45.8 ± 1.8 vs. 46.8 ± 2.9 ms, respectively; P = 0.33). Conversely, in patients, T2 values did differ between 2D (46.7 ± 3.6 ms) and 3D techniques (50.1 ± 4.2 ms, P = 0.004). Moreover, with the 2D technique, T2 values of the LGE-positive segments were similar to those of the LGE-negative segments (T2LGE−= 46.2 ± 3.7 vs. T2LGE+ = 47.6 ± 4.1 ms; P = 0.49), whereas the 3D technique did show a significant difference (T2LGE− = 49.3 ± 6.7 vs. T2LGE+ = 52.6 ± 8.7 ms, P = 0.006).Conclusion: Respiratory motion-registered 3D radial imaging at 1.5T led to accurate isotropic 3D whole-heart T2 maps, both in the healthy volunteers and in a small patient cohort with suspected non-ischemic myocardial injury. Significantly higher T2 values were found in patients as compared to controls in 3D but not in 2D, suggestive of the technique's potential to increase the sensitivity of CMR at earlier stages of disease. Further study will be needed to demonstrate its accuracy.

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Cardiovascular magnetic resonance native T2 and T2* quantitative values for cardiomyopathies and heart transplantations: a systematic review and meta-analysis

Cited by 25 publications

References 201 publications

Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients

Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients

Cardiac magnetic resonance imaging with T2 mapping for the monitoring of acute heart transplant rejection in patients with problematic endomyocardial biopsy: in anticipation of new recommendations

Respiratory Motion-Registered Isotropic Whole-Heart T2 Mapping in Patients With Acute Non-ischemic Myocardial Injury

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