Cardiovascular pharmacology of aqueous extract of the leaves of Bridelia atroviridis Muell. Arg. (Euphorbiaceae) in the rat

Corallo, A.; Foungbe, S; Davy, M; Cohen, Y.

doi:10.1016/s0378-8741(97)00071-8

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…It is interesting to note the presence of lignans in the genus Bridelia: 5 -demethoxy-␤-peltatin-5-O-␤-d-glucopyranoside (7) and ␤-peltatin-5-O-␤-d-glucopyranoside (8) isolated from Bridelia ferruginea roots, exhibited antitumor activity (Rhashid et al, 2000), while the new lignan glycoside bridelioside, the known neolignan Abbiw (1990), Agyare et al (2006), Corallo et al (1997) and Neuwinger (2000) …”

Section: Metabolites Occurring In Bridelia Speciesmentioning

confidence: 99%

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The genus Bridelia: A phytochemical and ethnopharmacological review

Ngueyem

Brusotti

Caccialanza

et al. 2009

Journal of Ethnopharmacology

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Section: Metabolites Occurring In Bridelia Speciesmentioning

confidence: 99%

“…In vitro, the extract induced dose-dependent negative inotropic and chronotropic effects in isolated rat heart. Bridelia atroviridis seemed to have a direct effect on rat heart and the extract might act through potential dependent calcium channels (Corallo et al, 1997).…”

Section: Bridelia Atroviridis Muell Argmentioning

confidence: 99%

The genus Bridelia: A phytochemical and ethnopharmacological review

Ngueyem

Brusotti

Caccialanza

et al. 2009

Journal of Ethnopharmacology

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“…Several species of this genus have been used in traditional medicinal systems for the management of multiple diseases, including diabetes, urinary stones, lumbago, rheumatism, venereal diseases, bronchitis, gastrointestinal problems, cardiac pain, infertility, epilepsy, and diarrhoea, among others [9]. Keeping this in view, the biological efficacy of several Bridelia species has been claimed in several research pieces [10][11][12][13][14][15]. In earlier studies, the chemical profiles of the members of the Bridelia genus have been reported.…”

Section: Introductionmentioning

confidence: 99%

Bridelia speciosa Müll.Arg. Stem bark Extracts as a Potential Biomedicine: From Tropical Western Africa to the Pharmacy Shelf

et al. 2020

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Bridelia species have been used in traditional African medicine for the management of diverse human ailments. In the current work, the detailed phytochemical profiles of the extracts of the stem bark of B. speciosa were evaluated and the antioxidant and enzyme inhibitory properties of the extracts were assessed. The anti-bacterial and anti-mycotic effects of the extracts were evaluated against selected pathogen strains. Additionally, the anti-proliferative effects were studied on the liver cancer HepG2 cell line. Finally, the putative protective effects were assessed on isolated rat liver that was challenged with lipopolysaccharide (LPS). The results revealed the presence of 36 compounds in the ethyl acetate extract, 44 in the methanol extract, and 38 in the water extract. Overall, the methanol extract showed the highest antioxidant activity, particularly in LPS-stimulated rat liver. Additionally, this extract exerted the highest antimycotic effect on C. albicans, whereas the water extract showed a promising anti-proliferative effect on liver cancer HepG2 cells. The methanol extract was also the most active as enzyme inhibitor, against acetylcholinesterase and butyrylcholinesterase. The current study appraises the antioxidant and enzyme inhibition properties of B. speciosa methanol extract and showed that this specie could be a promising source of biologically active phytochemicals, with potential health uses. Supplementary Materials: The following are available online at http://www.mdpi.com/2076-3921/9/2/128/s1. Supplementary Materials and Methods; CFF-strains. Author Contributions: Conceptualization, C.F. and G.Z.; methodology, G.O.; L.M.; software, L.M.; validation,: C.F.; G.Z.; L.M.; G.O.; formal analysis, C.F.; G.Z.; investigation, K.I.S.; K.B.; S.L.; L.R.; A.C. (Annalisa Chiavaroli); S.V.; P.A.; V.H.; S.C.; R.V.; L.D.L.; A.C. (Alessandro Cama); M.C.N.P.-A.; Z.C.; J.J.; M.F.M.; resources, C.F.; G.O.; L.M.; data curation, C.F.; G.Z.; writing-original draft preparation, M.F.M.; writing-review and editing, C.F., G.Z.; G.O.; L.M.; visualization, L.B.; supervision, L.B.; project administration, C.F.; L.M.; G.O.; G.Z.; funding acquisition, C.F.; G.O.; L.M. All authors have read and agreed to the published version of the manuscript.

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“…Hibiscus sabdariffa have been used in ethnomedicine for the management of hypertension (Nworgu et al, 2008;Salghdeen et al, 2004;Carallo et al, 1997;Obiefuna and Owolabi, 1993). Extracts of these plants have been tested in various animal models and are shown to possess hypotensive properties supporting their use in the treatment of hypertension.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the blood pressure lowering activity of leaf extract of Acalypha torta Muell

Ezekwesili¹

2012

Afr. J. Pharm. Pharmacol.

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The leaf of Acalypha torta Muell. (Euphorbiaceae) is used as folk remedy in Nigeria for the treatment of hypertension. Effects of extracts of A. torta leaf on the blood pressure of anaesthetized cats were studied to examine this claim. The ethanol extract produced a significant (p < 0.0001) and dosedependent fall in arterial blood pressure. The extract inhibited adrenaline -induced contraction of isolated rabbit aortic strips and produced a significant (p < 0.0001) and dose -dependent increase in the rate of flow of physiologic fluid through the rat hind-quarters preparation. Both evidences indicate relaxant effect of the ethanol extract on vascular smooth muscle. Calcium chloride -induced tachycardia was abolished following administration of the extract. It had no effect on the rate of contraction of the isolated rabbit heart, but reduced the force of contraction. Column chromatography was performed and Fraction L, eluted with distilled water, was found to be responsible for the reduction in blood pressure.

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Cardiovascular pharmacology of aqueous extract of the leaves of Bridelia atroviridis Muell. Arg. (Euphorbiaceae) in the rat

Cited by 7 publications

References 7 publications

The genus Bridelia: A phytochemical and ethnopharmacological review

The genus Bridelia: A phytochemical and ethnopharmacological review

Bridelia speciosa Müll.Arg. Stem bark Extracts as a Potential Biomedicine: From Tropical Western Africa to the Pharmacy Shelf

Evaluation of the blood pressure lowering activity of leaf extract of Acalypha torta Muell

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