Cardiovascular Risk Factors in Elderly Normolipidaemic Acute Myocardial Infarct Patients

Kumar, Arun

doi:10.5772/30955

Cited by 16 publications

(20 citation statements)

References 49 publications

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“…In a study done by Haraki T.et al it was observed that by univariate analysis, CCA-IMT was positively correlated with age (r=0.51, p < 0.01), LDL-c/HDL-c ratio (r=0.37, p<0.01), triglycerides (r=0.23, p < 0.05), and negatively correlated with HDL-cholesterol (r=-0.31,p< 0.01). 18 Our findings are very similar to the findings of Haraki et al, 15 excepting for the age. In a study done by Nagasaki T, et al 19 it was observed that CCAIMT change was closely associated with basal levels of total cholesterol (r = 0.472, p= 0.0031), low-density lipoprotein (LDL) cholesterol (r = 0.441, p= 0.0076) and the total/HDL cholesterol ratio (r = 0.435, p= 0.0057) 55 which is similar to the current study.…”

Section: Resultssupporting

confidence: 82%

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Common Carotid Artery Intima-Media Thickness Reflects the Cumulative Burden of Atherosclerosis and Predicted Well by Total-C/HDL-C Ratio in Type-II Diabetic Patients- A Case Control Study Based from Kolkata, India

Dey

Kumar

et al. 2013

Asian J Med Sci

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Background: Diabetes Mellitus (DM) is frequently associated with the development of premature atherosclerotic vascular disease and is the major cause of morbidity and mortality. Approximately 80% of all deaths and more than 75% of all hospitalizations are due to CAD. Individuals with DM are usually associated with accelerated atherosclerosis. Common Carotid artery intima-media thickness (CCAIMT) is now also considered as a surrogate marker of atherosclerosis. Materials and Methods: This case-control study was conducted from Jan, 2011 to June, 2012 among Type-II diabetes, aged between 30-80yrs. Patients with Type-I diabetes, aged <30yrs or >80yrs and other secondary causes of diabetes, hypertensive, smokers and patients under therapy with lipid lowering drugs were excluded from this study. The biochemical tests were done in the department of Biochemistry, Nilratan Sarkar Medical College and Hospital, using standardized reagent kits. CCAIMT was measured by high resolution imaging using 10MHz transducer in the department of Radiodiagnosis, Nilratan Sarkar Medical College and Hospital. Results: The results of our study indicate that dyslipidemic diabetic patients had significantly higher blood glucose at any phase along with glycated haemoglobin compared to controls. The lipid variables were also significantly higher in the diabetes patients with dyslipidemia compared to controls except HDL levels were significantly higher in control. CCAIMT was higher in the dyslipidemic group (1.71 ± 0.57mm) compared to the non-dyslipidemic group (0.77 ± 0.10) which was statistically significant (p value <0.001). Conclusion: CCAIMT reflects the cumulative burden of atherosclerosis and is highly correlated and predicted well by Total-C/HDL-C ratio in Type-II diabetic patients. So it is advised that a direct examination of the vessel wall is extremely essential for early detection of the affected individuals so that the cost burden in Intensive coronary care unit can be minimized and also the individual can be advised to control the extensive dyslipidemia through dietary restrictions and exercise. DOI: http://dx.doi.org/10.3126/ajms.v5i1.8450 Asian Journal of Medical Science Vol.5(1) 2014 pp.9-14

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Section: Resultssupporting

confidence: 82%

“…In another study conducted by Kumar, et al 14,15,16,17 also observed that TC, TC/HDL-C ratio, TG, LDL-C, LDL-C/HDL-C ratio were higher in MI patients (p<0.001). HDL-C concentration was significantly lower in MI patients than controls (p<0.001).…”

Section: Resultsmentioning

confidence: 93%

Common Carotid Artery Intima-Media Thickness Reflects the Cumulative Burden of Atherosclerosis and Predicted Well by Total-C/HDL-C Ratio in Type-II Diabetic Patients- A Case Control Study Based from Kolkata, India

Dey

Kumar

et al. 2013

Asian J Med Sci

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“…6 A case control study by Kumar et al reported significantly higher total cholesterol and triglyceride levels and lower high density lipoprotein cholesterol (HDL-C) levels in patients admitted with acute myocardial infarction. 7 Blood cholesterol has a log-linear relationship to the risk of cardiovascular disease and is estimated that in high-income countries blood cholesterol levels in excess of 3.8 mmol/litre are responsible for more than 50% of CVD events. 8 Limited information exists regarding the changing time-trends in lipid levels and the prevalence of dyslipidaemia in Indian subjects.…”

Section: Asian Journal Of Medical Sciences 5(2014) 1-8mentioning

confidence: 99%

Dyslipidemia and its Relationship with Cardiovascular Risk Factors in a Selected Population of Siliguri City, West Bengal, India.

et al. 2013

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Background:Dyslipidemia, one of the classical Framingham risk factors of cardiovascular diseases, accounts significantly to the rise of non communicable diseases in India. Urbanization, along with greater consumption of dietary fats and decreased physical activity, has led to an increase in this problem manifold. Objectives: To determine the prevalence of dyslipidemia among urban adults of Siliguri city, West Bengal and to identify the cardio-vascular risk factors associated with it.Methods: This descriptive, cross-sectional study was carried out among the 226 adults aged ≥20yrs in an urban area of Siliguri city, West Bengal, India. Data was collected by detailed history and physical examination; biochemical measurements were done using standards procedures. Dyslipidemia was defined by the presence of one or more than one abnormal serum lipid concentration. Statistical analysis was done using chi-square test, t test and logistic regression analysis using SPSS 20 software (Chicago, IL, USA).Results: Dyslipidemia was prevalent among 78.4 % of the total study subjects. Dyslipidemia was more in males than in females & in both males and females it was more prevalent in the age group 40 -59 years than in any other age group. It was associated with higher odds of major cardiovascular risk factors like hypertension, hyperglycemias, and tobacco use. Conclusion:Dyslipidemia remains a significant and growing problem in this part of the country. The reduction in the disease burden will require changes in life style as well as in national policies.

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“…8 Kumar et al observed significantly higher total cholesterol (TC) and triglyceride (TG) levels and lower high-density lipoprotein cholesterol (HDL) levels in AMI patients. 9 Woo et al observed higher mean TC, LDL, and TG as well as lower mean HDL in AMI patients; high HDL was among the protective factors. 10 It is well known fact that early treatment of hyperlipidemia following acute myocardial infarction (AMI) provides potential benefits and reduces the morbidity and mortality of coronary heart disease.…”

Section: Introductionmentioning

confidence: 99%

Lipid profile and its correlation with C-reactive protein in patients of acute myocardial infarction

et al. 2017

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INTRODUCTIONAcute myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die. This is most commonly due to occlusion of a coronary artery following the rupture of a vulnerable atherosclerotic plaque which is an unstable collection of lipids (cholesterol and fatty acids) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death (infarction) of heart muscle tissue (i.e. myocardium). 1,2Acute myocardial infarction (AMI) continues to be a major cause of morbidity and mortality worldwide.3,4 It remains a leading cause of death in India and represents an enormous cost to health care system. 5 The mortality rate of MI is approximately 30% and for every 1 in 25 patients who survive the initial hospitalization, dies in the first year after AMI. Indians are four time more prone to AMI as compared to the people of other countries due to a combination of the genetic and lifestyle factors that promote metabolic dysfunction. The risk of ABSTRACT Background: Acute myocardial infarction (AMI) is a significant cause of morbidity and mortality worldwide, which results from occlusion of coronary artery. Dyslipidemia is a major risk factor of AMI. C-reactive protein (CRP) is an acute phase protein, synthesized by hepatocytes in response to cytokines released into circulation by activated leukocytes and has been found to increase after AMI. The objective of the present study is to investigate lipid profile in AMI patients and correlate it with inflammatory marker i.e. CRP. Methods: The present study includes 150 AMI patients and 100 normal healthy individuals as controls. In all the cases and controls, serum lipid profile and inflammatory marker were measured by diagnostic kits supplied by ERBA. Results: The levels of lipid profile and inflammatory marker were significantly altered in the AMI cases compared to controls. We found significantly higher levels of total cholesterol, TG, LDL, VLDL, CRP and lower level of HDL in AMI compared to that of control subjects. We also found strong positive correlation of CRP with total cholesterol, triglyceride, LDL-C and VLDL-C and significant negative correlation with HDL-C in AMI patients. Conclusions: We found alterations in the lipid profile and inflammatory marker in AMI cases; hence, all the people should undergo regular check up including lipid profile evaluation and inflammatory marker such as CRP to decrease the incidence, morbidity and mortality from the disease.

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Cardiovascular Risk Factors in Elderly Normolipidaemic Acute Myocardial Infarct Patients

Cited by 16 publications

References 49 publications

Common Carotid Artery Intima-Media Thickness Reflects the Cumulative Burden of Atherosclerosis and Predicted Well by Total-C/HDL-C Ratio in Type-II Diabetic Patients- A Case Control Study Based from Kolkata, India

Common Carotid Artery Intima-Media Thickness Reflects the Cumulative Burden of Atherosclerosis and Predicted Well by Total-C/HDL-C Ratio in Type-II Diabetic Patients- A Case Control Study Based from Kolkata, India

Dyslipidemia and its Relationship with Cardiovascular Risk Factors in a Selected Population of Siliguri City, West Bengal, India.

Lipid profile and its correlation with C-reactive protein in patients of acute myocardial infarction

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