Cariogenic and oral health taxa in the oral cavity among children and adults: A scoping review

Bhaumik, Deesha; Manikandan, Divya; Foxman, Betsy

doi:10.1016/j.archoralbio.2021.105204

Cited by 18 publications

(18 citation statements)

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“…We observed a well-documented succession from Streptococcus- dominated, low-diversity communities to more diverse communities by 24 months of age with stabilization thereafter [ 11 , 12 , 24 , 25 ]. As in cross-sectional dental research, we found an association between S. mutans and ECC at the time of ECC diagnosis [ 8 ]. Like previous prospective studies of ECC, we found evidence for an association between early life salivary bacteriome composition and future ECC [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 95%

“…Microbial digestion of carbohydrates to acids which demineralize tooth enamel is the proximate cause [ 5 – 7 ]. Acid-producing bacteria, particularly Streptococcus mutans ( S. mutans ) , are frequently associated with ECC [ 5 , 8 ]. No single bacterial species, however, has been conclusively identified as a necessary and sufficient cause of ECC across human populations [ 5 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…Acid-producing bacteria, particularly Streptococcus mutans ( S. mutans ) , are frequently associated with ECC [ 5 , 8 ]. No single bacterial species, however, has been conclusively identified as a necessary and sufficient cause of ECC across human populations [ 5 , 8 , 9 ]. Recent research emphasizes the ecologic hypothesis, which posits that overall shifts in the composition, structure, functional potential of the oral microbial community leads to dental decay [ 5 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the ecological hypothesis: early life salivary microbiome assembly predicts dental caries in a longitudinal case-control study

et al. 2022

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Background Early childhood caries (ECC)—dental caries (cavities) occurring in primary teeth up to age 6 years—is a prevalent childhood oral disease with a microbial etiology. Streptococcus mutans was previously considered a primary cause, but recent research promotes the ecologic hypothesis, in which a dysbiosis in the oral microbial community leads to caries. In this incident, density sampled case-control study of 189 children followed from 2 months to 5 years, we use the salivary bacteriome to (1) prospectively test the ecological hypothesis of ECC in salivary bacteriome communities and (2) identify co-occurring salivary bacterial communities predicting future ECC. Results Supervised classification of future ECC case status using salivary samples from age 12 months using bacteriome-wide data (AUC-ROC 0.78 95% CI (0.71–0.85)) predicts future ECC status before S. mutans can be detected. Dirichlet multinomial community state typing and co-occurrence network analysis identified similar robust and replicable groups of co-occurring taxa. Mean relative abundance of a Haemophilus parainfluenzae/Neisseria/Fusobacterium periodonticum group was lower in future ECC cases (0.14) than controls (0.23, P value < 0.001) in pre-incident visits, positively correlated with saliva pH (Pearson rho = 0.33, P value < 0.001) and reduced in individuals who had acquired S. mutans by the next study visit (0.13) versus those who did not (0.20, P value < 0.01). In a subset of whole genome shotgun sequenced samples (n = 30), case plaque had higher abundances of antibiotic production and resistance gene orthologs, including a major facilitator superfamily multidrug resistance transporter (MFS DHA2 family PBH value = 1.9 × 10−28), lantibiotic transport system permease protein (PBH value = 6.0 × 10−6) and bacitracin synthase I (PBH value = 5.6 × 10−6). The oxidative phosphorylation KEGG pathway was enriched in case plaque (PBH value = 1.2 × 10−8), while the ABC transporter pathway was depleted (PBH value = 3.6 × 10−3). Conclusions Early-life bacterial interactions predisposed children to ECC, supporting a time-dependent interpretation of the ecological hypothesis. Bacterial communities which assemble before 12 months of age can promote or inhibit an ecological succession to S. mutans dominance and cariogenesis. Intragenera competitions and intergenera cooperation between oral taxa may shape the emergence of these communities, providing points for preventive interventions.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluating the ecological hypothesis: early life salivary microbiome assembly predicts dental caries in a longitudinal case-control study

et al. 2022

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“…The changes in the fungal microbiome, or the mycobiome, were similar to those of the bacteriome, with the relative abundance of several taxa that mainly belong to candida increasing significantly in the dental plaque on caries surfaces [ 92 ]. The microbiome research of dental caries has not detected any specific microbial species uniquely associated with caries [ 102 ].…”

Section: Resultsmentioning

confidence: 99%

“…Considering repeatability, only species that were reported in at least two studies were included as being caries-related or health-related. As shown in Figure 1 , only Streptococcus mutans from saliva was shown to be significantly associated with caries in adults, while a variety of taxa from both saliva and plaque were reported to be caries-related or health-related in children [ 102 ].…”

Section: Resultsmentioning

confidence: 99%

Oral Microbiome and Dental Caries Development

Zhang

Chu

2022

Dentistry Journal

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Dental caries remains the most prevalent oral disease worldwide. The development of dental caries is highly associated with the microbiota in the oral cavity. Microbiological research of dental caries has been conducted for over a century, with conventional culture-based methods and targeted molecular methods being used in order to identify the microorganisms related to dental caries. These methods’ major limitation is that they can identify only part of the culturable microorganisms in the oral cavity. Introducing sequencing-based technology and bioinformatics analysis has boosted oral microbiome research and greatly expanded the understanding of complex oral microbiology. With the continuing revolution of molecular technologies and the accumulated sequence data of the oral microbiome, researchers have realized that microbial composition alone may be insufficient to uncover the relationship between caries and the microbiome. Most updated evidence has coupled metagenomics with transcriptomics and metabolomics techniques in order to comprehensively understand the microbial contribution to dental caries. Therefore, the objective of this article is to give an overview of the research of the oral microbiome and the development of dental caries. This article reviews the classical concepts of the microbiological aspect of dental caries and updates the knowledge of caries microbiology with the results of current studies on the oral microbiome. This paper also provides an update on the caries etiological theory, the microorganisms related to caries development, and the shifts in the microbiome in dental caries development.

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Antibacterial coating of orthodontic elastomeric ligatures with silver and bismuth nanofilms by magnetron sputtering: A feasibility study

Schubert,

Griesmüller,

Gersdorff

et al. 2024

Clinical & Exp Dental Res

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ObjectivesMagnetron sputtering was evaluated to equip surfaces of orthodontic elastomeric ligatures with silver and bismuth nanofilms.Material and MethodsAntibacterial properties were evaluated by the adhesion of Streptococcus mutans. Polyurethane‐based elastomeric ligatures were coated with silver and bismuth nanofilms via direct current magnetron sputtering. Surface roughness (Ra) and surface‐free energy (SFE) were assessed. Coated specimens were incubated with S. mutans for 2 h. Adhering bacteria were visualized by Hoechst staining and quantified by an ATP‐based luminescence assay. One‐way analysis of variance with Tukey post hoc testing and Pearson correlation analysis were performed (p < .05) to relate bacterial adhesion to surface roughness and surface‐free energy.ResultsElastomeric ligatures were successfully coated with silver and bismuth nanofilms. Ra was significantly reduced by silver coating. Silver and bismuth coatings showed significantly higher SFE than controls. Adhesion of S. mutans was significantly decreased by silver coating. No correlation between bacterial adhesion and SFE was found. Correlation between bacterial adhesion and Ra was positive but not statistically significant.ConclusionsMagnetron sputtering proved to be a feasible method to equip orthodontic elastomeric ligatures with silver and bismuth nanofilms. Silver coatings of elastomeric ligatures may reduce white spots and carious lesions in orthodontic patients. Future research is required to stabilize coatings.

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Cariogenic and oral health taxa in the oral cavity among children and adults: A scoping review

Cited by 18 publications

References 50 publications

Evaluating the ecological hypothesis: early life salivary microbiome assembly predicts dental caries in a longitudinal case-control study

Evaluating the ecological hypothesis: early life salivary microbiome assembly predicts dental caries in a longitudinal case-control study

Oral Microbiome and Dental Caries Development

Antibacterial coating of orthodontic elastomeric ligatures with silver and bismuth nanofilms by magnetron sputtering: A feasibility study

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