Carnitine as a free radical scavenger in aging

Rani, Packiasamy Juliet Arockia; Panneerselvam, C.

doi:10.1016/s0531-5565(01)00116-4

Cited by 120 publications

(22 citation statements)

References 25 publications

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“…L-Car significantly enhances antioxidant vitamin levels [30]. Acetyl-L-Car has the capacity to enhance antioxidants such as vitamins C and E [32] and melatonin [33]. L-Car could influence the homeostasis of eye lens with an antiapoptotic and/or antioxidative activity or by interfering on the biochemical modifications of lens proteins [34].…”

Section: Discussionmentioning

confidence: 99%

Selenium and l-Carnitine Reduce Oxidative Stress in the Heart of Rat Induced by 2.45-GHz Radiation from Wireless Devices

Türker

Nazıroğlu

Gümral

et al. 2011

Biol Trace Elem Res

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The aim of this study was to investigate the possible protective role of selenium and L-carnitine on oxidative stress induced by 2.45-GHz radiation in heart of rat. For this purpose, 30 male Wistar Albino rats were equally divided into five groups namely controls, sham controls, radiation-exposed rats, radiation-exposed rats treated with intraperitoneal injections of sodium selenite at a dose of 1.5 mg/kg/day, and radiation-exposed rats treated with intraperitoneal injections of L-carnitine at a dose of 1.5 mg/kg/day. Except for the controls and sham controls, the animals were exposed to 2.45-GHz radiation during 60 min/day for 28 days. The lipid peroxidation (LP) levels were higher in the radiation-exposed groups than in the control and sham control groups. The lipid peroxidation level in the irradiated animals treated with selenium and L-carnitine was lower than in those that were only exposed to 2.45-GHz radiation. The concentrations of vitamins A, C, and E were lower in the irradiated-only group relative to control and sham control groups, but their concentrations were increased in the groups treated with selenium- and L-carnitine. The activity of glutathione peroxidase was higher in the selenium-treated group than in the animals that were irradiated but received no treatment. The erythrocyte-reduced glutathione and β-carotene concentrations did not change in any of the groups. In conclusion, 2.45-GHz electromagnetic radiation caused oxidative stress in the heart of rats. There is an apparent protective effect of selenium and L-carnitine by inhibition of free radical formation and support of the antioxidant redox system.

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Section: Discussionmentioning

confidence: 99%

Selenium and l-Carnitine Reduce Oxidative Stress in the Heart of Rat Induced by 2.45-GHz Radiation from Wireless Devices

Türker

Nazıroğlu

Gümral

et al. 2011

Biol Trace Elem Res

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“…Those not sharing the same letters are significant thesis, supplementation of LC spares ascorbic acid and thereby elevates its level, (2) LC also acts as a chelator and hence decreases the amount of iron available for LPO, signifying the fact that these antioxidants act synergistically to protect the cells against OS. Since ascorbic acid, vitamin E and GSH are linked tightly to each other, the oxidizability of vitamin E is controlled by the level of endogenous antioxidants (Rani and Paneerselvam 2001). Oxidation of proteins by free radicals plays a major role in many oxidative processes within the cells, the magnitude of which is often measured by the carbonyl content (Hawkins and Davies 2001).…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress in erythrocytes: a study on the effect of antioxidant mixtures during intermittent exposures to high altitude

2010

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The aim of our study was to compare and assess the effectiveness of antioxidant mixtures on the erythrocytes (RBC) of adult male albino rats (Wister) subjected to simulated intermittent high altitudes--5,100 m (AL(1)) and 6,700 m (AL(2))--to induce oxidative stress (OS). To achieve our objective, we pre-supplemented four sets of animals with different antioxidant mixtures [vitamin E (vit.E; 50 IU/kg BW), vitamin C (vit.C; 400 mg/kg) and L: -carnitine (400 mg/kg)] in different combinations [M1 (vit.E+vit.C), M2 (vit.C+carnitine), M3 (vit.E+carnitine) and M4 (vit.C+vit.E+carnitine)] for 30 days prior to as well during exposure to intermittent hypobaric hypoxia (IHH). Membrane instability, in terms of osmotic fragility and hemolysis, decreased in RBCs of supplemented animals. There was a significant increase in the activity of glutathione peroxidase in the RBCs of supplemented animals. We confirmed OS imposed by IHH with assays relating to lipid [thiobarbituric acid reactive substances (TBARS) and lipofuscin (LF)] and protein (carbonyl, PrC) oxidation, and found a positive correlation between PrC and hemolysis, with a decrease in both upon supplementation with M3 and M4 mixtures. Fluorescence microscopic observation showed a maximum decrease in the LF content in rats administered M4 and M1 compared to those on M2 and M3 mixtures at both altitudes. We suggest that multiple antioxidant fortifications are effective in overcoming increased OS experienced by RBCs at high altitudes.

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“…L-CAR also acts as a chelator by decreasing the concentration of cytosolic iron, which plays a very important role in free radical chemistry (Rani and Panneerselvam 2002). Acetyl-L-CAR has the capacity to enhance enzymatic and non-enzymatic antioxidants such as GSH-Px, GSH, vitamin E, vitamin C (Arockia- Rani and Panneerselvam 2001), and melatonin (Olatunji-Bello and Reiter 1997). Similarly to the L-CAR results in the current study, there are currently increasing evidences, and human experimental studies, suggesting that the antioxidant vitamins and L-CAR administrations as antioxidant and cytoprotective medicine were protective agents on oxidative stress-induced tissue injury in cancer treatment with EMR (Ü çü ncü et al 2006, Nazıro glu 2007a, Kocer et al 2007.…”

Section: Discussionmentioning

confidence: 99%

Modulator effects of L-carnitine and selenium on wireless devices (2.45 GHz)-induced oxidative stress and electroencephalography records in brain of rat

Nazıroğlu¹,

Gümral

2009

International Journal of Radiation Biology

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Carnitine as a free radical scavenger in aging

Cited by 120 publications

References 25 publications

Selenium and l-Carnitine Reduce Oxidative Stress in the Heart of Rat Induced by 2.45-GHz Radiation from Wireless Devices

Selenium and l-Carnitine Reduce Oxidative Stress in the Heart of Rat Induced by 2.45-GHz Radiation from Wireless Devices

Oxidative stress in erythrocytes: a study on the effect of antioxidant mixtures during intermittent exposures to high altitude

Modulator effects of L-carnitine and selenium on wireless devices (2.45 GHz)-induced oxidative stress and electroencephalography records in brain of rat

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