Carnosine-graphene oxide conjugates decorated with hydroxyapatite as promising nanocarrier for ICG loading with enhanced antibacterial effects in photodynamic therapy against Streptococcus mutans

Gholibegloo, Elham; Karbasi, Ashkan; Pourhajibagher, Maryam; Chiniforush, Nasim; Ramazani, Ali; Akbari, Tayebeh; Bahador, Abbas; Khoobi, Mehdi

doi:10.1016/j.jphotobiol.2018.02.004

Cited by 89 publications

(56 citation statements)

References 57 publications

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“…Graphene plays a reinforcing role in graphene-HA nanocomposites. High specific surface area with honeycomb structure and thickness of about one carbon atom has made graphene excellent reinforcing properties [8][9][10][11]. Graphene has been used as a reinforcing phase to overcome the weakness of the mechanical properties of HA.…”

Section: Introductionmentioning

confidence: 99%

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

Nosrati

Sarraf-Mamoory

et al. 2020

Nano Ex.

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In this study, the hydroxyapatite (HA)-reduced graphene oxide (rGO) nanocomposite was investigated for its mechanical properties. The nanocomposite used in this study was made in two stages. The HA-rGO powders were first synthesized by hydrogen gas injected hydrothermal method, and then consolidated by spark plasma sintering. HA-rGO nanocomposite was subjected to Vickers indentation experiments with different loading rates. Various analyzes have been used in this study, including x-rays diffraction, field emission scanning electron microscopy, high-resolution transmission electron microscopy, fast fourier transform, and inverse fast fourier transform. The findings of this study showed that the HA in this nanocomposite was reinforced with rGO sheets coated with HA. As the loading rate increased, the slope of the curves in the elastic region was increased, indicating that the elastic modulus was increased. Also, the contact depth at higher loading rates was increased. Plastic deformation was higher at higher loading rates and the hardness had increased. As the loading rate increased from 300 mN to 1 N, the hardness and elastic modulus increased with more slope than when the loading rate changed from 1 N to 2 N. The presence of rGO sheets had partially controlled the HA brittleness.

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Section: Introductionmentioning

confidence: 99%

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

Nosrati

Sarraf-Mamoory

et al. 2020

Nano Ex.

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“…The most important of these properties are low fracture toughness (fracture toughness of less than 1 MPa.m 0.5 ), intrinsic brittleness, poor tensile strength, and weak wear resistance [1][2][3][4]. However, despite these poor mechanical properties, HA has excellent biological properties, including bone bonding ability, excellent biocompatibility, highly compatible with living bone tissues, scaffolding properties, and osteoconductive properties [5][6][7][8][9][10]. These properties have made HA widely used in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Nosrati

Sarraf-Mamoory

Ahmadi

et al. 2020

JNT

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In order to investigate the effect of graphene nanoribbons on the final properties of hydroxyapatite-based nanocomposites, a solvothermal method was used at 180 °C and 5 h for the synthesis of graphene nanoribbons–hydroxyapatite nanopowders by employing hydrogen gas injection. Calcium nitrate tetrahydrate and diammonium hydrogenphosphate were used as calcium and phosphate precursors, respectively. To synthesize the powders, a solvent containing diethylene glycol, anhydrous ethanol, dimethylformamide, and water was used. Graphene oxide nanoribbons were synthesized by chemical unzipping of carbon nanotubes under oxidative conditions. The synthesized powders were consolidated by spark plasma sintering methodat 950 °C and a pressure of 50 MPa. The powders and sintered samples were then evaluated using X-ray diffraction, Raman spectroscopy, high-resolution transmission electron microscopy, Vickers microindentation techniques, and biocompatibility assay. The findings of this study showed that the final powders synthesized by the solvothermal method had calcium to phosphate ratio of about 1.67. By adding a small amount of graphene nanoribbon (0.5%W), elastic modulus and hardness of hydroxyapatite increased dramatically. In biological experiments, the difference of hydroxyapatite effect in comparison with the nanocomposite was not significant. The findings of this study showed that graphene nanoribbons have a positive effect on the properties of hydroxyapatite, and these findings would be useful for the medical and theranostic application of this type of nanocomposites.

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“…Nowadays, nanobiomaterials have become popular in drug delivery systems and regenerative medicine [1,2]. These materials are widely applied in cancer therapy [3,4], photodynamic therapy [5] and tissue engineering including cartilage and bone regeneration [6,7].…”

Section: Introductionmentioning

confidence: 99%

Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds

Alipour

Aghazadeh

Akbarzadeh

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Presently, tissue engineering has been developed as an effective option in the restoration and repair of tissue defects. One of the tissue engineering strategies is to use both biodegradable scaffolds and stimulating factors for enhancing cell responses. In this study, the effect of zeolite was assessed on cell viability, proliferation, osteo/odontogenic differentiation, and mineralization of human dental pulp stem cells (hDPSCs) cultured on poly (e-coprolactone)poly (ethylene glycol)-poly (e-caprolactone) (PCL-PEG-PCL) nanofibers. For this purpose, PCL-PEG-PCL nanofibrous scaffolds incorporated with zeolite were prepared via electrospinning. Both PCL-PEG-PCL and PCL-PEG-PCL/Zeolite nanofibrous scaffolds revealed bead-less constructions with average diameters of 430 nm and 437 nm, respectively. HDPSCs were transferred to PCL-PEG-PCL nanofibrous scaffolds containing zeolite nanoparticles. Cell adhesion and proliferation of hDPSCs and their osteo/odontogenic differentiation on these scaffolds were evaluated using MTT assay, Alizarin red S staining, and qRT-PCR assay. The results revealed that PCL-PEG-PCL/Zeolite nanofibrous scaffolds could support better cell adhesion, proliferation and osteogenic differentiation of hDPSCs and as such is expected to be a promising scaffold for bone tissue engineering applications.

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Carnosine-graphene oxide conjugates decorated with hydroxyapatite as promising nanocarrier for ICG loading with enhanced antibacterial effects in photodynamic therapy against Streptococcus mutans

Cited by 89 publications

References 57 publications

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

Investigating the mechanical behavior of hydroxyapatite-reduced graphene oxide nanocomposite under different loading rates

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds

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