Carotid atherosclerosis and arterial peripheral pulse wave velocity in cerebral thrombosis

Tamaki, Toru; Keiko, Sawada; Hayashi, Shinya; Node, Yoji; Teramoto, Akira

doi:10.1016/j.jocn.2005.02.012

Cited by 16 publications

(13 citation statements)

References 24 publications

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“…baPWV is a recently developed noninvasive method for the automatic measurement of PWV, and is strongly associated with aortic PWV [20], the existence of carotid atherosclerosis, and abdominal aortic calcification [21, 22]. …”

Section: Discussionmentioning

confidence: 99%

Association between Cerebral Arterial Calcification and Brachial-Ankle Pulse Wave Velocity in Patients with Acute Ischemic Stroke

et al. 2009

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Background/Aims: Vascular calcification is known to be associated with cardiovascular mortality, and arterial stiffness measured by pulse wave velocity is associated with major cardiovascular risk factors. The aim of the present study was to elucidate the correlation between arterial stiffness and cerebral arterial calcification. Methods: Arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV), and cerebral arterial calcification, as measured by CT angiography using a 40-multidetector scanner, were examined in patients with acute ischemic stroke. Sixty-seven subjects who were free of renal disease or peripheral arterial disease were included in the analysis. Results: Univariate analysis revealed that baPWV was significantly correlated with cerebral arterial calcification (r = 0.524, p < 0.001) and age (r = 0.452, p < 0.001), and multiple linear regression analysis indicated that age and cerebral arterial calcification were independent determinants of baPWV. Conclusion: We report that increased baPWV is closely associated with the degree of cerebral arterial calcification in patients with acute ischemic stroke. Our results suggest that the severity of cerebral arterial calcification is representative of the degree of systemic arterial stiffness.

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Section: Discussionmentioning

confidence: 99%

Association between Cerebral Arterial Calcification and Brachial-Ankle Pulse Wave Velocity in Patients with Acute Ischemic Stroke

et al. 2009

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“…Kubozono et al first reported that high baPWV was a strong predictor of increased carotid IMT (≥1.0 mm) in 1,583 Japanese male subjects undergoing routine health check-up (75). Following cross-sectional studies have also showed the association between baPWV and increased carotid IMT or carotid plaque formation in general population (76), and patients with type 2 diabetes (77), end-stage renal disease (78), and cerebral artery thrombosis (79). Other PWV of other arterial tree segments including carotid-cerebral PWV (80), aorto-popliteal PWV (81), and heart-carotid PWV (82) also showed significant association with carotid atherosclerosis.…”

Section: Pwv In Carotid Artery Atherosclerosismentioning

confidence: 99%

Pulse Wave Velocity in Atherosclerosis

Kim

2019

Front. Cardiovasc. Med.

293

226

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Early detection of subclinical atherosclerosis is important to reduce patients' cardiovascular risk. However, current diagnostic strategy focusing on traditional risk factors or using risk scoring is not satisfactory. Non-invasive imaging tools also have limitations such as cost, time, radiation hazard, renal toxicity, and requirement for specialized techniques or instruments. There is a close interaction between arterial stiffness and atherosclerosis. Increased luminal pressure and shear stress by arterial stiffening causes endothelial dysfunction, accelerates the formation of atheroma, and stimulates excessive collagen production and deposition in the arterial wall, leading to the progression of atherosclerosis. Pulse wave velocity (PWV), the most widely used measure of arterial stiffness, has emerged as a useful tool for the diagnosis and risk stratification of cardiovascular disease (CVD). The measurement of PWV is simple, non-invasive, and reproducible. There have been many clinical studies and meta-analyses showing the association between PWV and coronary/cerebral/carotid atherosclerosis. More importantly, longitudinal studies have shown that PWV is a significant risk factor for future CVD independent of well-known cardiovascular risk factors. The measurement of PWV may be a useful tool to select subjects at high risk of developing subclinical atherosclerosis or CVD especially in mass screening.

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“…Under severe conditions, however, AS may lead to restricted blood supply toward the brain, leading to symptoms including headache and dazedness. Further activity of neck may further aggravate blood ischemia, or even lead to the formation of cerebral thrombosis [15,16]. AS is the basic pathogenic factor for cerebral thrombosis, and is caused by deposition of lipid components of blood onto artery endothelial layer under various stimuli.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of advanced glycation end products in type II diabetic patients with acute cerebral infarction

Ju¹,

Zhao²,

Li³

et al. 2018

biomedicalresearch

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Background: Advanced glycation end products (AGEs) are reported to be associated with diabetic vascular complications. However, the role of AGEs in the pathogenesis of cerebral thrombosis remains unclear. This study aimed to investigate the relationship between advanced glycation end products (AGEs) generation and pathogenesis of cerebral thrombosis. Methods: 100 patients with cerebral thrombosis were recruited and 50 healthy controlled individuals were served as a control group. Enzyme Linked Immunosorbent Assay (ELISA) was applied for measuring serum AGEs level. The condition of carotid intima was examined by carotid ultrasonography. Serum AGEs levels were compared among patients with certain conditions of carotid atherosclerosis. Results: AGEs levels in carotid plaque or thickening groups showed significant difference compared with those in control group. Carotid plaque patients showed remarkably different AGEs levels compared to thickening patients. AGEs levels were significantly elevated with higher severity of carotid plaque. Moderate or severe stenosis patients, or blocked group showed significantly different AGEs compared to mild stenosis group. Severe stenosis or blockade group showed remarkably different AGEs compared with moderate stenosis patients. In addition, severe stenosis group had statistically different AGEs compared with blockade group. Conclusion: AGEs level is correlated with pathogenesis of cerebral thrombosis and they are further elevated with aggravation of carotid atherosclerosis in patients, suggesting they might be used as a biomarker to evaluate the severity of atherosclerosis.

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Carotid atherosclerosis and arterial peripheral pulse wave velocity in cerebral thrombosis

Cited by 16 publications

References 24 publications

Association between Cerebral Arterial Calcification and Brachial-Ankle Pulse Wave Velocity in Patients with Acute Ischemic Stroke

Association between Cerebral Arterial Calcification and Brachial-Ankle Pulse Wave Velocity in Patients with Acute Ischemic Stroke

Pulse Wave Velocity in Atherosclerosis

Serum levels of advanced glycation end products in type II diabetic patients with acute cerebral infarction

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