Carotid Body Tumors: A Case Series and Review of the Literature

Darouassi, Youssef; Alaoui, M.; Touati, Mohamed; Maghraoui, Oussama Al; Ennouali, Amine; Bouaity, Brahim; Ammar, Haddou

doi:10.1016/j.avsg.2017.03.167

Cited by 47 publications

(64 citation statements)

References 35 publications

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“…Paraganglioma arising from the carotid body is an asymptomatic and slow growing tumor, which accounts for 60% to 70% of head and neck paragangliomas [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

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Differential Diagnosis and Treatment Outcomes of Tumors at the Carotid Bifurcation

Kang

Heo

Park

et al. 2020

VSI

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Purpose Primary tumor at the carotid bifurcation is uncommon, which includes paraganglioma, schwannoma, and lymphoma. Due to their rarity, characteristics of these tumors and problems related to their surgical treatment have not been well known. We tried to elucidate different clinical characteristics and surgical complications of these tumors. Materials and Methods We retrospectively reviewed 21 patients with carotid bifurcation tumor from the Vascular Surgery division of a Korean tertiary institution from 1995 to 2018. We investigated patients’ demographics and clinical features, image characteristics, treatment details, and surgical outcomes. Results During the period from January 1995 to January 2018, we experienced surgical resections of 21 carotid bifurcation tumors which included 16 (76.2%) paragangliomas and 5 (23.8%) schwannomas. The most common clinical feature was a non-tender cervical mass. According to Shamblin classification, paragangliomas were classified into class II in 68.8% and class III in 25.0%. On the preoperative computed tomography images, all the paragangliomas showed characteristic splaying of the carotid bifurcation and hypervascularity of the tumors. On the contrary, all the schwannomas showed hypovascularity and splaying sign in 60%. Surgical complications related to cervical nerve injury developed in 50% and 60% of patients with Shamblin class III paraganglioma and schwannoma, respectively. During the mean follow-up period of 25 months (range, 1 to 163 months), distant metastases developed in 2 (12.5%) of paraganglioma patients. Conclusion Neurologic complications were more common after surgical resection of Shamblin class III paraganglioma and schwannoma. For patients with paraganglioma, postoperative periodic follow-up examination is advised to detect distant metastasis.

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“…Paraganglioma arising from the carotid body is an asymptomatic and slow growing tumor, which accounts for 60% to 70% of head and neck paragangliomas [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most common reason to seek medical attention is a non-tender, palpable neck mass at the carotid triangle of the neck [ 5 ]. The majority of cervical paragangliomas are nonfunctioning, while less than 5% of the cervical paragangliomas are functioning with secretion of the catecholamine from the tumor [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Differential Diagnosis and Treatment Outcomes of Tumors at the Carotid Bifurcation

Kang

Heo

Park

et al. 2020

VSI

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“…The majority of them are nonsecretory and present with head and neck manifestations, such as neck masses, hoarseness, dysphagia, cough, or vertigo. [1] They can also arise anywhere outside of the head and neck along the sympathetic chain, with these much more likely to be secretory (86%). Catecholamine secreting paragangliomas can present with systemic effects of the catecholamines, which account for only about 5% of initial presentations.…”

Section: Discussionmentioning

confidence: 99%

Severe Dry Cough as Presenting Symptom of Patient with Five Paragangliomas

Waddick¹,

Asarkar²,

Mirfakhraee³

et al. 2020

AJMCR

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“…4 Even though CBTs are usually benign asymptomatic neoplasms, their proximity to cranial nerves as to the vasculature in the neck can result in signs and symptoms that are reported to cause a decrease in the HRQoL. 4,5,12,13,14 As aforementioned, surgical resection is a wellestablished treatment in these patients; however, assessment of HRQoL has become a subject of great importance when deciding which treatment could bring more benefit to the patients; given that the near absence of the pathology (i.e. complete tumor resection) does not always mean an improvement in the patient's HRQoL.…”

Section: Discussionmentioning

confidence: 99%

“…There has been an increased use of preoperative imaging studies for the accurate diagnosis, assessment and outcome prediction of CBTs. 14,15 Based in the involvement of the carotid arteries, Shamblin et al proposed a classification in three groups. This classification commonly could be used to predict difficulty or complications in CBT resection.…”

Section: Discussionmentioning

confidence: 99%

Assessment of health-related quality of life in patients prior to carotid body tumor resection

et al. 2019

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Background Carotid body tumors represent approximately 0.5% of the total head and neck tumors, and the most common presentation form is an asymptomatic cervical mass. Despite of being most of them asymptomatic the quality of life could be impacted; however, the literature remains silent about this matter. The Short Form 36 (SF-36) is a health-related quality of life (HRQoL) instrument that includes eight domains to assess physical and emotional function in different diseases. The aim of this study was to compare HRQoL in preoperative patients with carotid body tumor and a control paired group. The secondary objective was to compare HRQoL between carotid body tumor patients according to the volume tumor and Shamblin classification. Methods A cross-sectional study that included 23 patients diagnosed with carotid body tumor prior to resection and 23 control patients paired by age and gender was conducted from January 2017 to December 2018. The SF-36 questionnaire was applied in 46 patients. Three-dimensional volume reconstruction and estimation (3DVR) was obtained from a preoperative computed tomography angiography (CTA). Descriptive statistical analysis was performed for demographics and categorical variables were reported by frequencies and percentages. Continuous variables were summarized using median with interquartile ranges (IQR) with 95% confidence interval (CI) and were compared. Differences between medians were analyzed with the Mann–Whitney U test and all statistical tests were two-sided. Results In the carotid body tumor group, the mean age was 55 years, females were more frequently affected 19 (83%). Shamblin I was identified in 9% of patients, Shamblin II in 52% and Shamblin III in 39%. Carotid body tumor laterality were 57% right, 34% left and 9% bilateral tumors. The eight domains that comprise the SF-36 questionnaire were statistically significant when compared to the control group. Conclusion Significant differences were found in all SF-36 domains in carotid body tumor patients in comparison to control subjects, confirming that this neoplasm has negative impact in the general HRQoL.

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Carotid Body Tumors: A Case Series and Review of the Literature

Cited by 47 publications

References 35 publications

Differential Diagnosis and Treatment Outcomes of Tumors at the Carotid Bifurcation

Differential Diagnosis and Treatment Outcomes of Tumors at the Carotid Bifurcation

Severe Dry Cough as Presenting Symptom of Patient with Five Paragangliomas

Assessment of health-related quality of life in patients prior to carotid body tumor resection

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