Cartilaginous and Osseous Metaplasia With Bone Marrow Formation in the Aortic Valve of a Patient With Giant Cell Aortitis

Charokopos, Nikolaos; Antonitsis, Polychronis; Rouska, Efthymia; Kostopoulos, Ioannis; Charaf, Adnan; Spanos, Panagiotis

doi:10.1016/j.athoracsur.2005.07.039

Cited by 5 publications

(1 citation statement)

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“…The topic of bone formation in cardiac valves appears infrequently in the literature and usually as small series or single case reports [2,4,5,11], perhaps because surgically resected, calcified valves are not routinely examined histologically. It has been shown that heterotopic bone formation is closely related to the process of calcification, such that its presence has been described particularly in the aortic valve, in the calcified annulus of the mitral valve (annular calcification) and, rarely, in arterial atherosclerotic plaques [3,8,9].…”

Section: Discussionmentioning

confidence: 99%

Bone formation in cardiac valves: a histopathological study of 128 cases

et al. 2007

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In a series of 1,177 patients with surgical valve resection, there were 128 (10.9%) patients with the histological finding of bone and/or cartilage formation (bony metaplasia; heterotopic ossification) in the excised valve (119 aortic, 9 mitral). The incidence was higher in men (12.8%) than in women (8.5%). The bony metaplasia was always associated with valvular calcification. The metaplastic changes were encountered in all types of calcific aortic valve disease (senile, bicuspid valve, post-rheumatic). The marrow of the heterotopic lamellar bone was mostly composed of adipose tissue. Frequently, it showed chronic inflammation with polyclonal plasmocytic infiltration. Complete haematopoiesis was present only rarely.

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