Caryophyllene-Rich Essential Oil of <i>Didymocarpus Tomentosa</i>: Chemical Composition and Cytotoxic Activity

Gowda, Prameela Javarayi; Ramakrishnaiah, H.; Krishna, V.; Narra, Sivakrishna; Jagannath, Nataraj

doi:10.1177/1934578x1200701131

Cited by 5 publications

(4 citation statements)

References 19 publications

(23 reference statements)

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“…[ 18 19 20 ] Important phytoconstituents of O. tenuiflorum and its phytochemical importance were summarized in Table 1 . [ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 ]…”

Section: Methodsmentioning

confidence: 99%

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents

Parasuraman¹,

Balamurugan²,

Christapher³

et al. 2015

Phcog Res

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Objective:The aim was to evaluate the anti-diabetic and anti-hyperlipidemic effects of hydroalcoholic extract of leaves of Ocimum tenuiflorum (Lamiaceae) and prediction of biological activities of its phytoconstituents using in vivo anti-diabetic model and in silico analysis respectively.Materials and Methods:The leaves of O. tenuiflorum were extracted with 60% ethanol, and the extract was used for further pharmacological screening. The acute toxicity of the extract was evaluated as per the guidelines set by the Organization for Economic Co-operation and Development, revised draft guidelines 423. The oral anti-diabetic activity of the hydroalcoholic extract of O. tenuiflorum (125, 250 and 500 mg/kg) was studied against streptozotocin (STZ) (50 mg/kg; i.p.) + nicotinamide (120 mg/kg; i.p.) induced diabetes mellitus. The animals were treated with the investigational plant extract and standard drug (glibenclamide) for 21 consecutive days and the effect of hydroalcoholic extract of O. tenuiflorum on blood glucose levels was measured at regular intervals. At the end of the study, blood samples were collected from all the animals for biochemical estimation, then the animals were sacrificed and the liver and kidney were collected for organ weight analysis. Prediction for pharmacological and toxicological properties of phytoconstituents of O. tenuiflorum was carried out using online web tools such as online pass prediction and lazar toxicity prediction.Results:The hydroalcoholic extract of O. tenuiflorum showed significant anti-diabetic and anti-hyperlipidemic activity at 250 and 500 mg/kg, and this effect was comparable with that of glibenclamide. Predicted biological activities of phytoconstituents of O. tenuiflorum showed presence of various pharmacological actions, which includes anti-diabetic and anti-hyperlipidemic activities. Prediction of toxicological properties of phytoconstituents of O. tenuiflorum did not show any major toxic effects.Conclusion:The hydroalcoholic extract of O. tenuiflorum showed significant anti-diabetic and anti-hyperlipidemic activity against STZ + nicotinamide induced diabetes mellitus in rats. Further studies are required to confirm the anti-diabetic and anti-hyperlipidemic activities of individual phytoconstituents of O. tenuiflorum.

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Section: Methodsmentioning

confidence: 99%

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents

Parasuraman¹,

Balamurugan²,

Christapher³

et al. 2015

Phcog Res

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“… [ 58 ] 13 Cichorium intybus (Root) Rtx-5 MS GC-MS (Qualitative) Column: 30.0 m × 0.20 mm I.D., 0.25 μm Medium: Helium as carrier gas, flow rate of 1 mL/min 2-methoxy phenol, 2,3-butanedione, 2-furfurylthiol, 2-thenylthio, 1-octene-3-one, 2-ethyl-3,5-dimethylpyrazine, 3-methylbutanal, 2,3- butanedione [ 59 , 60 ] 14 Dicentra spectabilis, HP-5 MS GC-MS (Qualitative and quantitative) Column: 30 m × 0.25 mm × 0.25 μm Medium: Helium as a carrier gas, flow rate of 1 mL/min Hordenine, Trisphaeridine, Hamayne, Caranine, Galanthine, Homolycorine, Galwesine [ 61 ] 15 Didymocarpus pedicellata (Leaf) GC/FID and GC/MS (Qualitative) Column: 30 mm in length, 0.25 mm i.d., and 1 µm Medium: Helium as carrier gas, flow rate of 1 µL/min β-caryophyllene, α-humulene, β-selinene and α-selinene, caryophyllene oxide, veridiflorol, spathulenol, and humulene oxide [ 62 ] 16 Dracocephalum moldavica , Ocimum americanum , Lophanthus anisatus , Monarda fistulosa , and Satureja hortensis (aerial parts) HP-5MS GC/MS Colum: HP-5 column (30 m × 0.25 mm i.d with 0.25 μm film thickness) Medium: Helium as carrier gas, flow rate of 1 mL/min. Geraniol, geranyl acetate, thymol, citral, β-caryophyllene [ 63 ] 17 Fragaria vesca (Berries) GC-MS (Qualitative and ...…”

Section: Review Findingsmentioning

confidence: 99%

Metabolomics and Network Pharmacology in the Exploration of the Multi-Targeted Therapeutic Approach of Traditional Medicinal Plants

Sharma

Yadav

2022

Plants

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Metabolomic is generally characterized as a comprehensive and the most copious analytical technique for the identification of targeted and untargeted metabolite diversity in a biological system. Recently, it has exponentially been used for phytochemical analysis and variability among plant metabolites, followed by chemometric analysis. Network pharmacology analysis is a computational technique used for the determination of multi-mechanistic and therapeutic evaluation of chemicals via interaction with the genomes involved in targeted or untargeted diseases. In considering the facts, the present review aims to explore the role of metabolomics and network pharmacology in the scientific validation of therapeutic claims as well as to evaluate the multi-targeted therapeutic approach of traditional Indian medicinal plants. The data was collected from different electronic scientific databases such as Google Scholar, Science Direct, ACS publication, PubMed, Springer, etc., using different keywords such as metabolomics, techniques used in metabolomics, chemometric analysis, a bioinformatic tool for drug discovery and development, network pharmacology, methodology and its role in biological evaluation of chemicals, etc. The screened articles were gathered and evaluated by different experts for their exclusion and inclusion in the final draft of the manuscript. The review findings suggest that metabolomics is one of the recent most precious and effective techniques for metabolite identification in the plant matrix. Various chemometric techniques are copiously used for metabolites discrimination analysis hence validating the unique characteristic of herbal medicines and their derived products concerning their authenticity. Network pharmacology remains the only option for the unique and effective analysis of hundreds of chemicals or metabolites via genomic interaction and thus validating the multi-mechanistic and therapeutic approach to explore the pharmacological aspects of herbal medicines for the management of the disease.

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“…217 The leaf essential oil of Didymocarpus tomentosa is rich in caryophyllane derivatives. 218 Biotransformations of 5a-hydroxycaryophyll-4(12),8(13)-diene with the fungi Cunninghamella elegans and Rhizopus stolonifer have been reported. 219 The rst total synthesis of rumphellaone A has been accomplished.…”

Section: Cadinane Copaane Oplopane and Cubebanementioning

confidence: 99%

Natural sesquiterpenoids

2013

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Caryophyllene-Rich Essential Oil of Didymocarpus Tomentosa: Chemical Composition and Cytotoxic Activity

Cited by 5 publications

References 19 publications

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Hydroalcoholic Extract of Leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents

Metabolomics and Network Pharmacology in the Exploration of the Multi-Targeted Therapeutic Approach of Traditional Medicinal Plants

Natural sesquiterpenoids

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