Case Report: Severe Plasmodium vivax Malaria Mimicking Sepsis in a Neonate

Tatura, Suryadi N. N.; Wowor, Elizabeth Clarissa; Mandei, Jose M.; Wilar, Rocky; Warouw, Sarah M.; Rompis, Johnny; Kalensang, Priscilla Cantia; Tuda, Joseph

doi:10.4269/ajtmh.17-0739

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…Moreover, several researchers highlighted the diagnostic value of neonatal blood count [15], indexes of leukocyte and neutrophil concentrations [16], plasma fibronectin level in sepsis screens in neonates [17], the value of thrombocytopenia [18], platelet count [19], and the value of serum procalcitonin [20]. A recent diagnosis [21] described the clinical future of severe sepsis signs and symptoms among neonates in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

Effective biomarkers for successful management of sepsis

El‐Nahhal¹,

Al_shareef²

2018

Trends Med

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Background:The main objective of this study was to demonstrate the effectiveness of daily measurements of liver enzymes along with c-reactive protein (CRP), and complete blood count (CBC) for the successful management of septic cases in neonates.Method: A sample of septic neonates (48 individuals), along with 40 non-septic neonates, was randomly selected for the daily measurement of liver function tests (aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP)), blood culture, CRP, and CBC during the routine medical treatments of sepsis cases in neonates. The abovementioned parameters were measured according to international laboratory standards. Data were statistically analyzed to determine whether there were correlations among parameters. Results:The data showed elevated levels of white blood cells (WBCs), ALT, AST, ALP, and CRP and a reduced level of platelets on the first day of medical treatment (on admission). Daily measurement of the parameters provides a trend with the direction of medical treatment. Strong correlations were found between CRP and blood parameters. Successful medical treatment indicated a continuous reduction of WBCs, ALT, ALP, AST and CRP and increased level of platelets to reach the values of the reference range and/or the control group at the end point. Conclusion:Daily measurements of ALT, AST, ALP and CRP along with blood counts are driving toward the successful diagnosis and management of septic cases in neonates. The implementation of these diagnostic parameters around the globe may reduce the morbidity and mortality in neonates.

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Section: Introductionmentioning

confidence: 99%

Effective biomarkers for successful management of sepsis

El‐Nahhal¹,

Al_shareef²

2018

Trends Med

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“…The low number of articles included in our search is alarming (n = 1, 5.8%) in view of the role of TLRs in P. vivax malaria. Although not often related to deaths, P. vivax is the most widely distributed Plasmodium species, being responsible for many cases of morbidity [ 1 , 4 ], and more recently also being described in cases of severe malaria [ 41 , 42 ]. This species also has epidemiological importance due to the characteristics of the parasite's biology that makes it difficult to interrupt the transmission cycle.…”

Section: Discussionmentioning

confidence: 99%

Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis

Ramírez

Jesus

Rossit

et al. 2022

Heliyon

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“…[4][5][6][7][8][9][10] Tatura et al showed that P. vivax infection in neonates presented with severe sepsis in endemic areas which was diagnosed by incidental findings of peripheral smear. 11 Severe anemia is the most common feature of P. falciparum malaria worldwide; however, in P. vivax-endemic areas, especially younger age group children are more prone for severe anemia with P. vivax infection. 2 The low parasite biomass burden of P. vivax indicates that due to rapid destruction of infected RBCs causing severe anemia and might be other pathophysiology plays adds on.…”

Section: Discussionmentioning

confidence: 99%

Case Report of P. Vivax: An Atypical Presentation in Pediatric Age

Supreetha¹,

Jayekar²,

Krishnappa³

2022

JCBS

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Worldwide Malarial infection remains a major cause for morbidity and mortality. Only 50-70% patients showed classic presentation of malaria with paroxysms of fever and rest unusual presentation might be because of impending resistance to antimalarial drugs and judicious use of antimalarial drugs and establishment of immunity. Here, we report peadiatric age group case of Vivax malaria with unusual presentation with history of generalized weakness with severe anemia and going for renal failure. He presented to emergency ward with failure to thrive and treatment started for nephrotic syndrome apparently no improvement in the patient. During laboratory investigation, found to be having malarial parasites in peripheral blood smear, for which immediate therapy was started. After first dose of antimalarial drug patient started showing some signs of recovery. Thus we would like to highlight atypical presentation of malaria, where early recognizing with treatment can save lives. Clinicians must be aware of unusual presentations and constant changes in epidemiology; difficulties in early detecting of severe manifestations of Plasmodium vivax malaria, emphasis must be made to lower the disease burden. Key words: P.vivax, anemia, malaria.

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Case Report: Severe Plasmodium vivax Malaria Mimicking Sepsis in a Neonate

Cited by 12 publications

References 20 publications

Effective biomarkers for successful management of sepsis

Effective biomarkers for successful management of sepsis

Association of toll-like receptors in malaria susceptibility and immunopathogenesis: A meta-analysis

Case Report of P. Vivax: An Atypical Presentation in Pediatric Age

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