Cases of Symptomatic Paralysis Agitans following Encephalitis Lethargica

Sa, Wilson

doi:10.1177/003591572001300232

Cited by 2 publications

(2 citation statements)

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“…We reviewed the epidemiological studies that sought to verify the PSH. Finally, we reviewed current and projected statistics provided by Dorsey's recent work, as well as other major epidemiological papers on Parkinson's disease [5, 6, 14, 18, 27–29]. …”

Section: Methodsmentioning

confidence: 99%

The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease

Estupinan

Nathoo

Okun

2013

Parkinson's Disease

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In 1961, David C. Poskanzer and Robert S. Schwab presented a paper, “Studies in the epidemiology of Parkinson's disease predicting its disappearance as a major clinical entity by 1980.” This paper introduced the hypothesis that Parkinson's disease was derived from a single aetiology, the influenza virus. We review the original Poskanzer and Schwab hypothesis that Parkinson's disease was based on the association between the 1918-19 influenza epidemic and the later observation of Parkinsonism in some influenza sufferers. We also further explore the prediction that Parkinson's disease would totally disappear as an entity once original influenza victims were all deceased. Current research has revealed that there are many potential causes and factors important in the occurrence of Parkinson's disease, postencephalitic Parkinsonism, and encephalitis lethargica. Poskanzer and Schwab presented a novel hypothesis; however, it was proven false by a combination of research and time.

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Section: Methodsmentioning

confidence: 99%

The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease

Estupinan

Nathoo

Okun

2013

Parkinson's Disease

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“…The possible association of viral infection of the CNS and Parkinson's disease has been suggested ever since the first cases of parkinsonian syndromes were described in 1920-21 (Wilson, 1920;Babinski and Jarkowski, 1920;Marie and Levy, 1920;Sicard, 1920;Souques, 1921;Blakeslee, 1921) as sequelae of encephalitis lethargica (von Economo's disease), a unique seemingly infectious disease of the nervous system that occurred in pandemic form from 1917 through 1928. An agent for this acute meningoencephalitis was never convincingly established with the available investigative methodology at that time despite intensive efforts at experimental transmission of diseased brain material with the goal of reproducing the original clinical and pathological features.…”

Section: Postencephalitic Parkinsonismmentioning

confidence: 99%

Viruses, Immunity, and Mental Disorders

Kurstak¹,

Lipowski²,

Morozov³

1987

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Cases of Symptomatic Paralysis Agitans following Encephalitis Lethargica

Cited by 2 publications

References 0 publications

The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease

The Demise of Poskanzer and Schwab’s Influenza Theory on the Pathogenesis of Parkinson’s Disease

Viruses, Immunity, and Mental Disorders

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