Catalase-mediated remediation of environmental pollutants and potential application – a review

Takio, Nene; Yadav, Meera; Yadav, Hardeo Singh

doi:10.1080/10242422.2021.1932838

Cited by 27 publications

(17 citation statements)

References 121 publications

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“…Some fungi and bacteria are known to biodegrade BPA with ligninolytic enzymes, such as lignin peroxidase, Mn peroxidase (MnP), and laccase, including Bacillus sp. from the human gut microbiota [ 69 , 70 ], or catalases, including manganese catalase [ 71 ]. In addition, MnP and laccase can degrade BPA and abolish its estrogenic effect [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Experimental Exposure to Bisphenol A Has Minimal Effects on Bone Tissue in Growing Rams—A Preliminary Study

Brankovič

Leskovec

Šturm

et al. 2022

Animals

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Bisphenol A (BPA) is a well-known synthetic compound that belongs to the group of endocrine-disrupting chemicals. Although bone tissue is a target for these compounds, studies on BPA-related effects on bone morphology in farm animals are limited. In this preliminary study, we investigated the effects of short-term dietary BPA exposure on femoral morphology, metabolism, mineral content, and biomechanical behavior in rams aged 9–12 months. Fourteen rams of the Istrian Pramenka breed were randomly divided into a BPA group and a control group (seven rams/group) and exposed to 25 µg BPA/kg bw for 64 days in feed. Blood was collected for determination of bone turnover markers (procollagen N-terminal propeptide, C-terminal telopeptide), and femurs were assessed via computed tomography, histomorphometry, three-point bending test, and mineral analysis. BPA had no significant effects on most of the parameters studied. Only mineral analysis showed decreased manganese (50%; p ≤ 0.05) and increased copper content (25%; p ≤ 0.05) in the femurs of BPA-exposed rams. These results suggest that a 2-month, low-dose exposure to BPA in growing rams did not affect the histomorphology, metabolism, and biomechanical behavior of femurs; however, it affected the composition of microelements, which could affect the histometric and biophysical properties of bone in the long term.

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Section: Discussionmentioning

confidence: 99%

Experimental Exposure to Bisphenol A Has Minimal Effects on Bone Tissue in Growing Rams—A Preliminary Study

Brankovič

Leskovec

Šturm

et al. 2022

Animals

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“…[ 1 ] In addition, CAT has great potential applications in biomedical, environmental, and industrial fields. [ 2–4 ] However, it is well known that natural CAT enzymes are high cost, sensitive to the environment and unstable, thus their applications are extraordinary finite. [ 5 ] Fortunately, the discovery of CAT‐like nanozymes has broken the deadlock.…”

Section: Introductionmentioning

confidence: 99%

Catalase‐Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

Yao

et al. 2022

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173

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The field of nanozymes has developed rapidly over the past decade. Among various oxidoreductases mimics, catalase (CAT)‐like nanozyme, acting as an essential part of the regulation of reactive oxygen species (ROS), has attracted extensive research interest in recent years. However, CAT‐like nanozymes are not as well discussed as other nanozymes such as peroxidase (POD)‐like nanozymes, etc. Compared with natural catalase or artificial CAT enzymes, CAT‐like nanozymes have unique properties of low cost, size‐dependent properties, high catalytic activity and stability, and easy surface modification, etc., which make them widely used in various fields, especially in tumor therapy and disease treatment. Consequently, there is a great requirement to make a systematic discussion on CAT‐like nanozymes. In this review, some key aspects of CAT‐like nanozymes are deeply summarized as: 1) Typical CAT‐like nanozymes classified by different nanomaterials; 2) The catalytic mechanisms proposed by experimental and theoretical studies; 3) Extensive applications in regard to tumor therapy, cytoprotection and sensing. Therefore, it is prospected that this review will contribute to the further design of CAT‐like nanozymes and optimize their applications with much higher efficiency than before.

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“…Catalases (EC 1.11.1.6) are iron porphyrin oxidoreductase enzymes that scavenge hydrogen peroxide into water and oxygen [ 1 , 2 ]. They are heme-containing tetrameric enzymes found in subcellular organelles (peroxisomes), the primary source of H 2 O 2 production during oxidative stress conditions via photorespiratory oxidation, beta oxidation of fatty acids, and purine catabolism [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Plant catalase in silico characterization and phylogenetic analysis with structural modeling

Takio

Yadav

2022

Journal of Genetic Engineering and Biotechnology

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Background Catalase (EC 1.11.1.6) is a heme-containing tetrameric enzyme that plays a critical role in signaling and hydrogen peroxide metabolism. It was the first enzyme to be crystallized and isolated. Catalase is a well-known industrial enzyme used in diagnostic and analytical methods in the form of biomarkers and biosensors, as well as in the textile, paper, food, and pharmaceutical industries. In silico analysis of CAT genes and proteins has gained increased interest, emphasizing the development of biomarkers and drug designs. The present work aims to understand the catalase evolutionary relationship of plant species and analyze its physicochemical characteristics, homology, phylogenetic tree construction, secondary structure prediction, and 3D modeling of protein sequences and its validation using a variety of conventional computational methods to assist researchers in better understanding the structure of proteins. Results Around 65 plant catalase sequences were computationally evaluated and subjected to bioinformatics assessment for physicochemical characterization, multiple sequence alignment, phylogenetic construction, motif and domain identification, and secondary and tertiary structure prediction. The phylogenetic tree revealed six unique clusters where diversity of plant catalases was found to be the largest for Oryza sativa. The thermostability and hydrophilic nature of these proteins were primarily observed, as evidenced by a relatively high aliphatic index and negative GRAVY value. The distribution of 5 sequence motifs was uniformly distributed with a width length of 50 with the best possible amino residue sequences that resemble the plant catalase PLN02609 superfamily. Using SOPMA, the predicted secondary structure of the protein sequences revealed the predominance of the random coil. The predicted 3D CAT model from Arabidopsis thaliana was a homotetramer, thermostable protein with 59-KDa weight, and its structural validation was confirmed by PROCHECK, ERRAT, Verify3D, and Ramachandran plot. The functional relationships of our query sequence revealed the glutathione reductase as the closest interacting protein of query protein. Conclusions This theoretical plant catalases in silico analysis provide insight into its physiochemical characteristics and functional and structural understanding and its evolutionary behavior and exploring protein structure-function relationships when crystal structures are unavailable.

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Catalase-mediated remediation of environmental pollutants and potential application – a review

Cited by 27 publications

References 121 publications

Experimental Exposure to Bisphenol A Has Minimal Effects on Bone Tissue in Growing Rams—A Preliminary Study

Experimental Exposure to Bisphenol A Has Minimal Effects on Bone Tissue in Growing Rams—A Preliminary Study

Catalase‐Like Nanozymes: Classification, Catalytic Mechanisms, and Their Applications

Plant catalase in silico characterization and phylogenetic analysis with structural modeling

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