Catalytic and antimicrobial studies of binuclear ruthenium(III) complexes containing bis-β-diketones

Priya, N. Padma; Arunachalam, S.; Sathya, N.; Chinnusamy, V.; Jayabalakrishnan, Chinnasamy

doi:10.1007/s11243-009-9214-z

Cited by 40 publications

(19 citation statements)

References 41 publications

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“…The XRD pattern of silica exhibits sharp peaks indicates its crystalline nature, while broad peak of nanosilica is indicative of amorphous nature . The diffraction pattern of Ru@imine‐nanoSiO 2 demonstrates new peaks at 2θ ≈ 19.06, 28.02, 38.6° and 58.1° corresponding to the (202), (213), (430) and (641) planes of octahedral Ru (III) complex . This difference in the XRD pattern of Ru@imine‐nanoSiO 2 and nanosilica is due to modification on the surface of nanosilica on successful immobilization.…”

Section: Resultsmentioning

confidence: 96%

Ru (III) Schiff‐base complex anchored on nanosilica as an efficient and retrievable catalyst for hydration of nitriles

Sultana

Borah

Gogoi

2018

Applied Organom Chemis

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Transition metal catalyzed hydration of nitriles is an attractive methodology for amide synthesis, and hence recently attracted wide attention. It is one of the significant organic transformations as amides play a vital role in biological, pharmaceutical and industrial applications. In this work, we report the synthesis of a new solid supported Ru (III) Schiff base complex, Ru@imine-nanoSiO 2 immobilized on nanosilica obtained from rice husk. The complex was characterized by FTIR, powder X-ray diffraction, BET surface area measurement, UV-vis, SEM-EDX, TEM, ESR, X-ray photoelectron spectroscopy and ICP-AES analysis. Using Ru@imine-nanoSiO 2 as the catalyst, the hydration of nitriles in i-PrOH at 40°C was studied which resulted in good isolated yields (60-99%). The catalyst can be recycled and reused up to 5 th cycle without any loss in activity. The products were characterized by FTIR, GC-MS and 1 H-NMR spectroscopy and compared with authentic samples.

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Section: Resultsmentioning

confidence: 96%

Ru (III) Schiff‐base complex anchored on nanosilica as an efficient and retrievable catalyst for hydration of nitriles

Sultana

Borah

Gogoi

2018

Applied Organom Chemis

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“…If G < 4.0, considerable exchange coupling might be present and generate the considerable misalignment. In this study, the observed G value of [CuLCl2]2 is 5.4 which explains that the local tetragonal axes are aligned parallel or slightly misaligned and exchange coupling could be worthless [48]. The observed empirical ratio of g| |/A|| value for the dimeric complex [CuLCl 2]2 is 162 which pointed out the octahedral geometry of dimeric [CuLCl2]2 with small distortion.…”

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confidence: 49%

Synthesis, Spectral Characterization, Docking Analysis, DNA Binding/Cleavage, Antimicrobial and Cytotoxic Activity of New Dimeric Antipyrine-Schiff Base Metal Complexes

Alaghaz¹,

Alturiqi²,

Ammar³

et al. 2018

Asian J. Chem.

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In the present study, a new series of novel Schiff base ligand derived from (furan-2-carbaldehyde and 4-aminoantipyrine) and dimeric metal(II) complexes with the composition of [MLCl2]2, where M=Cu(II), Co(II), Ni(II) and Zn(II) have been synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductivity measurements, FT-IR, UV-visible, 1 H NMR, 13 C NMR, EPR, MS (ESI), XRD, SEM and EDX studies. The spectral data recommend that the dimeric metal complexes embrace octahedral geometry around the central metal ions. The DMF solutions of the dimeric metal complexes demonstrate the lower molar conductance values which might be due to the non-electrolytic nature of the complexes (5.67-13.24 Ω -1 mol -1 cm -2 ). The biological studies involved are DNA interaction (binding and damage) antimicrobial, anti-proliferative and molecular docking. DNA interaction of these complexes carried out with using calf thymus DNA (CT-DNA) by electronic absorption titration, viscometric measurement which revealed that the synthesized dimeric complexes interact with DNA through intercalative binding mode. A gel electro-phoresis assay testifies the ability of complexes to cleave supercoiled pUC19 DNA in the presence of hydrogen peroxide as an activator. The synthesized compounds were initiated from their biological perspective. The antimicrobial assay indicates that dimeric complexes are good antimicrobial agents. Besides, in vitro antiproliferative activity of dimeric complexes were investigated on MCF-7, Hep G2, HBL-100 cell lines using an MTT assay. In addition, the molecular docking study was accomplished to considerate the nature of binding of the synthesized compounds with protein and DNA.

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“…From Table , it is clear that the inhibition diameters of the zinc(II) chelates are higher than that of the respective antibiotics. Such increased activity is attributed in part to the lipophilic nature of the zinc(II) ion in the complexes . However, the enhanced bactericidal activity of the zinc(II) ion upon coordination most probably arises from the contribution of the ligand moiety in the complex.…”

Section: Resultsmentioning

confidence: 99%

Antibacterial activity of transition metal complexes with a tridentate NNO amoxicillin derived Schiff base. Synthesis and characterization

Anacona

Mago

Camús

2018

Applied Organom Chemis

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From the reaction of amoxicillin (1) antibiotic with 2,6−diaminopyridine (2) an amoxicillin−based Schiff base (HL) (3) was obtained and its transition metal Schiff base complexes were synthesized. Spectroscopic and physicochemical techniques, namely, UV−Vis, FT−IR, 1H−NMR, EPR, mass spectrometry, molar conductance, magnetic susceptibility, molecular modelling, together with elemental and thermal analyses, were used to characterize the synthesized compounds. Spectral and magnetic data suggested an octahedral geometry for all the complexes and the general formulae [ML(H2O)3][PF6] (M(II) = Mn2+ (4), Co2+ (5), Ni2+ (6), Cu2+ (7), Zn2+ (8), was proposed for them, where L represents deprotonated tridentate NNO amoxycillin−derived Schiff base. All compounds were screened for antibacterial activity by using agar disc diffusion method. The zinc(II) complex exhibited promising bactericidal activity against E. coli and S. aureus.

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Catalytic and antimicrobial studies of binuclear ruthenium(III) complexes containing bis-β-diketones

Cited by 40 publications

References 41 publications

Ru (III) Schiff‐base complex anchored on nanosilica as an efficient and retrievable catalyst for hydration of nitriles

Ru (III) Schiff‐base complex anchored on nanosilica as an efficient and retrievable catalyst for hydration of nitriles

Synthesis, Spectral Characterization, Docking Analysis, DNA Binding/Cleavage, Antimicrobial and Cytotoxic Activity of New Dimeric Antipyrine-Schiff Base Metal Complexes

Antibacterial activity of transition metal complexes with a tridentate NNO amoxicillin derived Schiff base. Synthesis and characterization

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