Catalytic asymmetric total syntheses of (+)-α-cuparenone, (+)-cuparene and (+)-herbertene

Recent advances in palladium-catalysed asymmetric 1,4–additions of arylboronic acids to conjugated enones and chromones

“…Later in 2020, Bisai et al published the application of the L9/Pd(TFA) 2 catalytic system for the preparation of the enan-tiomers of other sesquiterpenoids by the addition reactions of tolylboronic acids to 3-methyl-2-cyclopentenone (Scheme 17) [13].…”

“…The asymmetric 1,4-addition of arylboronic acids to conjugated cyclic enones and chromones is a very important reaction nowadays. For illustration, the addition products are very promising in medicinal chemistry research [1][2][3][4][5][6][7] and in natural products total syntheses [8][9][10][11][12][13][14][15][16]. Chiral complexes of Rh [17][18][19][20][21][22][23][24] and Pd usually catalyse the reaction, however, palladium holds a special place in this area.…”