Electrochemical strategy has been the powerful approach for the synthesis of valuable intermediates, in particular heterocyclic motifs. It has proven to be an environmentally benign, highly effective and versatile platform...

Concise total syntheses of naturally occuring antiviral indolosesquiterpene alkaloids, xiamycin C (2a), D (2b), E (2c) and F (2d) have been achieved via a late-stage oxidative d-Csp3-H functionalization of an...

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Natural product synthesis has been the prime focus for the development of new carbon-carbon bond forming transformations. In particular, the construction of molecules with all-carbon quaternary centers remain one of the most facinating targets. In this regard, transitionmetal catalyzed processes have gained imporatnce owing to their mild nature. Towards this, Pd(0)-catalyzed decarboxylative allylations (DcA) is worth mentioning and has emerged as a convenient method for synthesis of molecules even in their enantioenriched form. However, in order to have a flexible approach that facilitate rapid production of derivatives by utilizing commercially available allyl alcohols, the concept of Pd(0)-catalyzed deacylative allylations (DaA) methodology gains popularity. In these reactions, the transfer of an acyl group has a functional role in activating the allylic alcohol (proelectrophile) toward reaction with Pd(0)-catalysts. We present here an Account on newly conceptualized deacylative allylations (DaA) methodology and its applications in the synthesis of various intermediates and building blocks. Further, its potential in the total synthesis of naturally occurring alkaloids have been summarized in this personal account.

FeCl3-catalyzed cyclization of arylvinylcarbinols for the synthesis of [6,5,6]-carbotricyclic core sharing an all-carbon quaternary center has been described in this full article. A careful mechanistic details suggest that the reaction follows a stepwise mechanism via the intermediacy of arylallyl carbocationic species. The carbocation subsequently reacts with an adjacent aromatic ring to form [6,5,6]-carbotricyclic scaffold of abeo-abietane diterpenoids. The methodology works under mild conditions to afford a variety of carbotricyclic core in good to excellent yields (up to 99% yield). Our strategy has been applied to a concise synthesis of a number of structurally intriguing naturally occurring taiwaniaquinoids, (±)-taiwaniaquinol F (1a), (±)-taiwaniaquinol B (1b), (±)-dichronanone (1c), (±)-taiwaniaquinone H (1d) and unnatural (±)-5-epi-taiwaniaquinone G (epi-1e).