Catanionic Surfactants: Novel Surrogates of Phospholipids

Manna, Kausik; Panda, Amiya Kumar

doi:10.1002/9781119075691.ch83

Cited by 4 publications

(3 citation statements)

References 73 publications

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“… Main transition temperatures of bilayers of a DeTMA‐DS, b DeTMA‐TS, c DTMA‐DS [5] and d DPPC respectively. …”

Section: Resultsmentioning

confidence: 99%

“…Three catanionic surfactants, including DeTMA-DS, DeTMA-TS and DTMA-DS, were synthesized as the starting materials for preparing catanionic vesicles. The DTMA-DS catanionic bilayer was chosen for its T m value of 41.4 °C close to the T m of 42.2 °C for the DPPC system [5]. We also analysed the properties of DeTMA-DS and DeTMA-TS vesicles to examine the effects of asymmetric alkyl chain combinations.…”

Section: Choice Of Catanionic Surfactantsmentioning

confidence: 99%

“…Further removing the inorganic counterions from the mixture results in uncharged molecular complexes considered as pseudodouble-chained with the two alkyl chains non-covalently bonded [3]. The controlled assembly of catanionic systems has many potential applications in drug delivery, pharmacy and material science [4][5][6]. Particularly, due to their abundant sources, low cost, high chemical stability and designable molecular structures, lipid-like catanionic surfactants have emerged as novel phospholipid surrogates to prepare potential vesicular carriers in drug and gene delivery [7][8][9][10][11][12][13][14][15][16][17].…”

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confidence: 99%

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Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes

et al. 2022

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Lipid-like ion-pair amphiphile vesicles, or catanionic vesicles, have emerged as potential drug carriers. The effects of cholesterol on the properties of catanionic vesicles have yet been systematically studied. Here, we compared the effects of cholesterol on the structures and fluidities of dipalmitoylphosphatidylcholine liposomes and catanionic vesicles with similar main transition temperatures (T m ). For liposomes, fluorescence anisotropy (FA) thermograms reveal typical condensing and disordering effects of cholesterol above and below T m respectively. In contrast, FA and molecular simulation data reveal that catanionic bilayers below T m are more fluidic due to shorter alkyl chains. This leads to only condensing effects of cholesterol for catanionic vesicles at all temperatures. Our results provide important insights into the fabrication of catanionic vesicles as novel drug carriers.

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“… Main transition temperatures of bilayers of a DeTMA‐DS, b DeTMA‐TS, c DTMA‐DS [5] and d DPPC respectively. …”

Section: Resultsmentioning

confidence: 99%

Section: Choice Of Catanionic Surfactantsmentioning

confidence: 99%

mentioning

confidence: 99%

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Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes

et al. 2022

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Carrier in carrier: Catanionic vesicles based on amphiphilic cyclodextrins complexed with DNA as nanocarriers of doxorubicin

Alarcón

Andrada

Olivera

et al. 2022

Journal of Molecular Liquids

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Interfacial and Aggregation Behavior of Dicarboxylic Amino Acid-Based Surfactants in Combination with a Cationic Surfactant

et al. 2019

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The interfacial and micellization behavior of three dicarboxylic amino acid-based anionic surfactants, abbreviated as AAS (N-dodecyl derivative of -aminomalonate, -aspartate, and -glutamate) in combination with hexadecyltrimethylammonium bromide (HTAB) were investigated by surface tension, conductance, UV−vis absorption/emission spectroscopy, dynamic light scattering (DLS), and viscosity studies. Critical micelle concentration (CMC) values of the surfactant mixtures are significantly lower than the predicted values, indicating associative interaction between the components. Surface excess, limiting molecular area, surface pressure at the CMC, and Gibbs free energy indicate spontaneity of the micellization processes compared to the pure components. CMC values were also determined from the sigmoidal variation in the plot of micellar polarity and pyrene UV−vis absorption/ emission intensities with surfactant concentration. The aggregation number, determined by static fluorescence quenching method, increases with decreasing mole fraction of the AAS (α AAS ), where the micelles are mainly dominated by the HTAB molecules. The size of the micelle increases with decreasing α AAS , leading to the formation of larger and complex aggregates, as also supported by the viscosity studies. Micelles comprising 20−40 mol % AAS are highly viscous, in consonance with their sizes. Some of the mixed surfactant systems show unusual viscosity (shear thickening and increased viscosity with increasing temperature). Such mixed surfactant systems are considered to have potential in gel-based drug delivery and nanoparticle synthesis.

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Catanionic Surfactants: Novel Surrogates of Phospholipids

Cited by 4 publications

References 73 publications

Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes

Divergent effects of cholesterol on the structure and fluidity of liposome and catanionic vesicle membranes

Carrier in carrier: Catanionic vesicles based on amphiphilic cyclodextrins complexed with DNA as nanocarriers of doxorubicin

Interfacial and Aggregation Behavior of Dicarboxylic Amino Acid-Based Surfactants in Combination with a Cationic Surfactant

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