Catechol and noradrenaline facilitate the neuromuscular transmission via different mechanisms.

Maéno, Takashi

doi:10.2170/jjphysiol.33.497

Cited by 3 publications

(3 citation statements)

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“…The dose-inhibition relation and a Lineweaver-Burk plot of the 4-AP data obtained for the dorsal root ganglion cells are presented in Fig. 7 A 3,4-diaminopyridine (Kirsch & Narahashi, 1978,1983. The extracellular site reported in this paper reacts with catechol.…”

Section: Effect Of Catechol On K+ Currentmentioning

confidence: 73%

“…Effect of 4-AP on the K+ current Since 4-AP is known to be a potent and specific blocker of the fast KK channels (Thompson, 1977;Dubois, 1981), it was of interest to compare the effects of catechol with those of 4-AP. 4-AP appears to react with a specific receptive site in the fast K+ channel more easily accessible from inside the nerve membrane than from outside (Kirsch & Narahashi, 1978, 1983. Consequently, eqns.…”

Section: Effect Of Catechol On K+ Currentmentioning

confidence: 99%

“…ITO AND T. MAENO of the voltage-dependent K+ conductance (Kaila & Saarikoski, 1980). This view might be supported by the finding that the facilitating effect of catechol is analogous to that of 4-aminopyridine (4-AP) (Maeno, Enomoto & Sawada, 1981;Maeno, 1983). However, despite many studies on the effects of catechol, no direct measurements seem to have been made on its blocking action on the K+ channels of excitable membranes.…”

Section: Introductionmentioning

confidence: 97%

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Catechol: a potent and specific inhibitor of the fast potassium channel in frog primary afferent neurones.

Ito¹,

Maéno²

1986

The Journal of Physiology

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SUMMARY1. The effects of catechol on various ionic channels of isolated primary afferent neurones of the bull-frog were examined by a single-suction-electrode clamp system, which combined internal perfusion and current or voltage clamp using an electronic switching circuit.2. Catechol was found to inhibit rather specifically the fast K+ current as does 4-aminopyridine (4-AP). Ca2+, Na+ and slow K+ currents were not affected.3. Although both 4-AP and catechol were inhibitors of the fast K+ channels, their sites of action were quite different. Catechol was effective when applied on the external surface of the cell membrane whereas 4-AP acted preferably internally.4. We assumed that a single fast K+ channel has two distinct sites for blockers: the catechol site is exposed to the external medium or situated at the outer orifice of the pore, and the 4-AP site is located within the same channel but is more easily accessible from inside the nerve cell than outside.5. The 4-AP and catechol sites were not, however, completely separate and independent of each other since a synergistic interaction was observed between catechol and 4-AP.

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Section: Effect Of Catechol On K+ Currentmentioning

confidence: 73%