Catecholamine-induced stimulation of testosterone production by Leydig cells from fetal mouse testis

Pointis, Georges; Latreille, Mathieu

doi:10.1530/jrf.0.0800321

Cited by 11 publications

(6 citation statements)

References 19 publications

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“…Remarkably, Pointis and Latreille (1987) showed that catecholamines may play an essential role in the control of testicular steroidogenesis Fig. 6 Immunohistochemical analyses of the expression of catecholamine-synthesizing enzymes in human testis during different (prenatal) developmental stages.…”

Section: Discussionmentioning

confidence: 99%

Catecholamine-synthesizing enzymes in the adult and prenatal human testis

Davidoff¹,

Ungefroren

Middendorff

et al. 2005

Histochem Cell Biol

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Catecholamines play functional roles in the mature and developing mammalian testis but the cell types responsible for their local synthesis are still controversially discussed. Here, we demonstrate that four enzymes involved in the biosynthesis of catecholamines, namely, tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine beta-hydroxylase (DBH) and phenylethanolamine- N-methyltransferase (PNMT), are expressed in Leydig cells of the human testis. Tyrosine hydroxylase, the key enzyme of the biosynthesis of catecholamines, was localized to Leydig cells both at the transcript level (by RT-PCR analyses and by in situ hybridization assays) and at the protein level (by immunoblotting and by immunohistochemistry). The other enzymes were also demonstrated in Leydig cells by RT-PCR and immunohistochemical analyses. The presence of TH, AADC, DBH, and PNMT in human Leydig cells was found, in addition, by immunohistochemical approaches carried out on sections from prenatal human testes. Thus, the present study identifies the Leydig cells as the presumed sites of catecholamine production in both the mature and fetal human testes and further supports the previously recognized neuroendocrine characteristics of this cell type.

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Section: Discussionmentioning

confidence: 99%

Catecholamine-synthesizing enzymes in the adult and prenatal human testis

Davidoff¹,

Ungefroren

Middendorff

et al. 2005

Histochem Cell Biol

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“…Endocrine effects: Mediated by changes in blood levels of different hormones, mainly testosterone and estrogen, or in the sensitivity of target tissues to these hormones. Data concerning the effect of adrenergic agonists on testosterone production and secretion by Leydig cells are inconclusive [20,[34][35][36][37]. Factors that regulate prostatic levels of androgen and estrogen receptors still have to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Induction of atypical prostatic hyperplasia in rats by sympathomimetic stimulation

et al. 1998

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BACKGROUND Prostatic innervation may participate in its homeostasis and growth. α‐Adrenergic inhibition alleviates clinical symptoms in benign prostatic hyperplasia. However, the prostatic effect of adrenergic agonists has not been investigated. This study deals with the prostatic effect of subchronic sympathomimetic stimulation. METHODS Male rats received daily subcutaneous injections of the α‐adrenergic agonist phenylephrine, 1, 10, or 20 mg/kg per day, the β‐adrenergic agonist isoproterenol, 1, 2.5 or 5 mg/kg per day, or saline, for 30 days, and the prostates were removed for histopathological examination. RESULTS Phenylephrine induced atypical prostatic hyperplasia, characterized by piling‐up with papillary and cribriform patterns, and budding‐out of epithelial cells. It decreased prostatic secretions and total weight. Similar results were observed in orchidectomized rats receiving exogenous testosterone supplementation. Isoproterenol had no prostatic morphological effect. CONCLUSIONS These results raise the possibility that sympathetic stimuli play a role in normal and aberrant growth and differentiation of prostatic epithelium, and suggests neurostimulants‐treated animals as a model to study the etiology and development of prostatic hyperplasia. Prostate 34:214–221, 1998.© 1998 Wiley‐Liss, Inc.

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“…Adrenergic nerves are present close to the Leydig cells in several species including man (Bell 1972). In vitro, catecholamines have been shown to increase testosterone production by the Leydig cells after a 24-h latent period via a beta-adrenergic mechanism (Pointis and Latreille 1987). Beta-adrenergic stimulation has been demonstrated to increase testosterone output from perfused canine testis and to increase testosterone synthesis (Eik-Nes 1969).…”

Section: Discussionmentioning

confidence: 99%

Pituitary-gonadal hormones during prolonged residency in Antarctica

Sawhney

Malhotra

Prasad

et al. 1998

International Journal of Biometeorology

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Plasma luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL) and testosterone levels were measured in nine eugonadal men in New Delhi and during the 1st week of different months of their stay at Dakshin Gangotri in Antarctica. During their 12-month stay in Antarctica, they were exposed to a severely cold climate, long polar nights and polar days, high wind velocity, increased amounts of solar and ultraviolet radiation and geomagnetism, as well as physical and social isolation. Plasma testosterone tended to increase in March, but a significant increase (P < 0.05) was not seen until April. The mean testosterone levels in May, June, September and November were also significantly higher than the March or New Delhi values. The absolute values of LH, FSH and PRL did not show any month-to-month changes in Antarctica. However, when the hormone levels were expressed as a percentage of the individual annual Antarctic mean, significant differences as a percentage of the individual annual Antarctic mean, significant differences were observed. The testosterone peak in April, May and June was associated with an increase in LH. The nadirs of testosterone, LH, FSH and PRL were seen in either July or August. FSH showed the highest values in March, whereas the highest PRL values were seen in November. These observations suggest the presence of circannual variations in gonadotropin, PRL and LH in Antarctica which are independent of polar days and polar nights. It appears that factors other than the duration of daylight might be involved in regulating these changes. The significance of maintenance of testosterone levels in the supra-physiological range in Antarctica remains unknown but may be important in acclimatization/habituation to the extreme polar cold by increasing basal metabolic rate, protein synthesis and erythropoiesis.

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Catecholamine-induced stimulation of testosterone production by Leydig cells from fetal mouse testis

Cited by 11 publications

References 19 publications

Catecholamine-synthesizing enzymes in the adult and prenatal human testis

Catecholamine-synthesizing enzymes in the adult and prenatal human testis

Induction of atypical prostatic hyperplasia in rats by sympathomimetic stimulation

Pituitary-gonadal hormones during prolonged residency in Antarctica

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