Cathepsin D content in malignant tumours of corpus uteri

Osmak, Maja; Babić, Damir; Abramić, Marija; Vrhovec, Ivan; Miličić, Duško; Škrk, Janez

doi:10.1016/s0959-8049(96)00490-x

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…that participate in the degradation of the basement membrane and digestion of extracellular matrix in the course of invasion and metastasis. These last comprise collagenase (1) and cathepsin D (34) which were found to be elevated not only in malignant endometrial tissue but also even in the hyperplastic (1) one, when these have been compared with normal or benign tissues (1,34) . The increased level of another proteolytic enzyme, DPP III has been reported in endometrial carcinomatous tissue by us, but its role in malignant growth is not elucidated (20) .…”

Section: Discussionmentioning

confidence: 99%

Total tissue lactate dehydrogenase activity in endometrial carcinoma

Šimaga¹,

Abramić²,

Osmak

et al. 2008

Int J Gynecol Cancer

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Lactate dehydrogenase (LDH) is essential for continuous glycolysis necessary for accelerated tumor growth. The aim of this study was to reconsider if assay of total tissue activity of this enzyme could be useful as marker for endometrial carcinoma. ) LDH activity was observed in endometrial carcinoma samples, if compared with normal uterine tissues. This rise was not related to the clinico-pathological findings, however. In contrast to previous results on LDH in ovarian carcinomas, a significant rise in LDH activity was found already in grade 1 endometrial carcinoma. Using the cutoff value of 1.06 U/mg, diagnostic sensitivity of 82%, specificity of 100% and accuracy of 91% for total tissue LDH assay have been calculated. A correlation of tissue's LDH and DPP III activities was found, and their combined assay for endometrial carcinoma showed increased diagnostic sensitivity (94 %) and accuracy (96 %).

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Section: Discussionmentioning

confidence: 99%

Total tissue lactate dehydrogenase activity in endometrial carcinoma

Šimaga¹,

Abramić²,

Osmak

et al. 2008

Int J Gynecol Cancer

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“…(Su et al, 2011;Xu et al, 2012). Compared to normal endometrium, concentrations of PAI-1 in cytosols of endometrial cancer were significantly higher (Kohler et al, 1997;Osmak et al, 2001). In addition, expression of PAI-1 was regulated by estrogen and progesterone, and appeared negatively correlated with estrogen and progesterone receptor levels (Fujimoto et al, 1996;Steiner et al, 2008).…”

Section: Role Of Other Adipocytokines In Endometrial Cancer Progressionmentioning

confidence: 99%

Role of adipocytokines in endometrial cancer progression

Dong

Zhang

et al. 2022

Front. Pharmacol.

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Endometrial cancer is considered a significant barrier to increasing life expectancy and remains one of the most common malignant cancers among women in many countries worldwide. The increasing mortality rates are potentially proportional to the increasing obesity incidence. Adipose tissue secretes numerous adipocytokines, which may play important roles in endometrial cancer progression. In this scenario, we describe the role of adipocytokines in cell proliferation, cell invasion, cell adhesion, inflammation, angiogenesis, and anti-apoptotic action. A better understanding of the mechanisms of these adipocytokines may open up new therapeutic avenues for women with endometrial cancer. In the future, larger prospective studies focusing on adipocytokines and specific inhibitors should be directed at preventing the rapidly increasing prevalence of gynecological malignancies.

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“…The homogenized tissues were centrifuged for 45 min at 41C and 15.000 g and the supernatants were used for biochemical studies [9]. Skin biopsy specimens were minced and homogenized in a lysis buffer containing Tris-HCl (10 mmol/l, pH 7.5), NaCl (150 mmol/l), Triton X-100 (1% vand phenylmethylsulfonyl fluoride (10 mmol/l).…”

Section: Sample Biopsy and Techniquementioning

confidence: 99%

Glutathione peroxidase and malondialdehyde in skin lesions of acne vulgaris

Moftah¹,

Hamad²,

Salam³

et al. 2011

Journal of the Egyptian Womenʼs Dermatologic Society

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BackgroundOxidative stress, the shift in ratio between oxidants and antioxidants, has not been confirmed yet as an etiological factor in acne vulgaris. Objective To detect the evidence of oxidative damage, precisely, in lesions of acne vulgaris of different severity. Patients and methodsThis study was carried out on 30 patients with acne vulgaris, eight males and 22 females, aged between 15 and 25 years, (mean: 19.3 ± 2.11 years) subdivided into four subgroups according to the disease severity: 10 patients with mild acne, 10 with moderate acne, 10 with severe acne, five with very severe acne, and 10 age and sex matched healthy controls. Glutathione peroxidase (GSH-PX) and malondialdehyde (MDA) levels were estimated spectrophotometrically in skin specimens from lesions of acne vulgaris and normal skin of healthy controls. ResultsThere was a high statistically significant decrease (P = 0.001) in GSH-PX enzyme levels in the patients compared with the controls whereas there was a high statistically significant increase (P = 0.006) in MDA levels in patient group compared with control group. There was statistically significant positive correlation between MDA levels and severity of acne vulgaris (r = 0.850, P = 0.0002) and a significant negative correlation between GSH-PX levels and severity of acne vulgaris (r = -0.722, P = 0.0006). In addition, there was a significant negative correlation between MDA and GSH-PX levels in the patient group (r = -0.055, P = 0.0007). ConclusionOxidative stress is evident in lesions of acne vulgaris according to the severity of the disease, which suggests its etiological role in acne vulgaris.

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Cathepsin D content in malignant tumours of corpus uteri

Cited by 6 publications

References 9 publications

Total tissue lactate dehydrogenase activity in endometrial carcinoma

Total tissue lactate dehydrogenase activity in endometrial carcinoma

Role of adipocytokines in endometrial cancer progression

Glutathione peroxidase and malondialdehyde in skin lesions of acne vulgaris

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