Caveolin-1 (CAV-1) up regulation in metabolic syndrome: all roads leading to the same end

Souza, Gabriela Montenegro de; Borborema, Maria Eduarda de Albuquerque; Lucena, Thays Maria Costa de; Santos, Alex Maurício Garcia; Lima, Brenda Regina de; Oliveira, Dinaldo Cavalcanti de; Silva, Jaqueline de Azevêdo

doi:10.1007/s11033-020-05945-y

Cited by 11 publications

(9 citation statements)

References 26 publications

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“…Caveolae could provide a possible platform for cell signal transduction [19]. It has been reported [20] that CAV1 expression is related to the clinical status of metabolic syndrome, and may become a potential target for the treatment and prevention of metabolic syndrome. CAV1 has also been confirmed to be expressed in lymphocytes and plays a potential role in latent HIV infection [21].…”

Section: Discussionmentioning

confidence: 99%

Plasma exosomal caveolin-1 predicts Poor Prognosis in Ovarian Cancer

Yang¹,

Wu²,

Zhu³

et al. 2021

J. Cancer

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Objective: In this study, we aimed to evaluate the levels of plasma exosomal caveolin-1(CAV1) and determine its prognostic value in ovarian cancer patients. Patients and Methods: Exosome-rich fractions were isolated from the plasma of 155 patients with ovarian cancer. TEM, NTA and western blot analysis were used to confirm the exosome integrity and purification. Results: Compared with healthy controls, plasma exosomal CAV1 levels in ovarian cancer patient were significantly down-regulated (P < 0.001). The low plasma levels of exosomal CAV1 in ovarian cancer patient plasma were related to FIGO stages, grades and lymph node metastasis (all P < 0.01). Among all ovarian cancer patients, DFS was worse in patients who had low plasma exosomal CAV1 levels compared with that in patients with high plasma exosomal CAV1 levels (P < 0.001). The OS of patients with low plasma exosomal CAV1 levels was shorter than that in patients with high plasma exosomal CAV1 levels (P < 0.001). The AUROC of plasma exosomal CAV1 was 0.76 (95% CI: 0.68-0.82) for DFS prediction in ovarian cancer patients, with a sensitivity 52.9 (95% CI: 42.8-62.9) and a specificity 88.7 (95% CI: 77.0-95.7). For OS prediction in ovarian cancer patients, the AUROC of plasma exosomal CAV1 was 0.78 (95% CI: 0.70-0.84), with a sensitivity 65.1 (95% CI: 49.1-79.0) and a specificity 81.2 (95% CI: 72.8-88.0). Conclusions: Low exosomal CAV1 levels were closely related to the FIGO stages I/II, low grade, lymph node metastasis and prognosis of ovarian cancer patients. Plasma exosomal CAV1 may be a potential biomarker for the prognosis in ovarian cancer patients.

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Section: Discussionmentioning

confidence: 99%

Plasma exosomal caveolin-1 predicts Poor Prognosis in Ovarian Cancer

Yang¹,

Wu²,

Zhu³

et al. 2021

J. Cancer

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“…The caveolae are a special form of lipid raft, which is a small invagination of the plasma membrane that is present in a number of mammalian cells, such as endothelial cells, adipocytes and skeletal muscle ( 27 , 28 ). Previous studies have reported that caveolae are the cellular center of signaling molecules ( 9 , 10 , 29 ). The formation and stability of the caveolae mainly depends on caveolin ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

“…Caveolae, which constitute specific forms of lipid rafts, are small invaginations of the plasma membrane that exist in numerous mammalian cells ( 7 , 8 ). Previous studies have reported that caveolae function as organizing centers for signaling molecules ( 9 , 10 ). Caveolins have cytoplasmic N and C termini, palmitoylation sites and a scaffolding domain that facilitates interaction and organization of signaling molecules so as to help provide coordinated and efficient signal transduction.…”

Section: Introductionmentioning

confidence: 99%

Role of caveolin‑1 in chronic postsurgical pain in rats

et al. 2021

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Chronic postsurgical pain (CPSP) has a high incidence, but the underlying mechanisms remain elusive. Previous studies have indicated that caveolin-1 (Cav-1) plays a notable role in pain modulation. To study the role of Cav-1 in CPSP in the present study, a rat model of skin/muscle incision and retraction (SMIR) was established. Under anesthesia, skin and superficial muscle of the medial thigh were incised and a small pair of retractors inserted. It was revealed that SMIR increased the expression of Cav-1 in the dorsal root ganglion (DRG) and the injured tissue around the incision. Furthermore, the infiltration of endothelial cells and macrophages in the injured tissue around the incision increased constantly, and the vascular permeability increased due to the destruction of the vascular endothelial barrier function around the injured tissue. Cav-1 was mainly expressed by CD68-positive macrophages and CD34-positive endothelial cells in the injured tissues around the incision, while it was also primarily localized in the medium and large neurofilament 200-positive neurons and a small number of calcitonin gene-related peptide- and isolectin B4-positive small and medium-sized neurons in the DRG. The results demonstrated that the sustained high expression levels of Cav-1 in the injured tissue around the incision could lead to the dysfunction of the vascular endothelial barrier and, thus, could induce the inflammatory response through the lipoprotein transport of endothelial cells, thereby resulting in peripheral sensitization. In addition, the sustained high expression levels of Cav-1 in the DRG could sensitize large-sized neurons and change the transmission mode of noxious stimuli. The findings of the present study indicated that a Cav-1-mediated process could participate in neuronal transmission pathways associated with pain modulation.

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“…Among these loci, variants near CCC141, BCAT1, and KIAA1755 have been previously related to heart rate or related traits in other genetic studies, 27,28 and variants near GJA1, GNB1, and MYH6 have been associated with conduction system abnormalities and other structural heart disease (Table 3). [29][30][31] Lastly, CAV1 has previously been associated with insulin resistance and metabolic syndrome, 32,33 in addition to HRR and other ECG-related traits. 24,34 In comparing SNPs associated with HRR pred against published GWAS on type 2 diabetes mellitus, we found that rs6127466 in KIAA1755 was also associated with diabetes (P 5 1.1 !…”

Section: Genetic Determinants Of Hrr Predmentioning

confidence: 99%