Caveolins as Regulators of Stress Adaptation

Schilling, Jan M.; Head, Brian P.; Patel, Hemal H.

doi:10.1124/mol.117.111237

Cited by 15 publications

(9 citation statements)

References 152 publications

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“…Caveolins partly build caveolae and their scaffolding domain has a key role in binding proteins that have been described to be involved in helium conditioning of the heart: e.g., the G-alpha subunit of heterotrimeric G-proteins, Src kinases, phosphatidylinositol 3-kinase (PI3K), eNOS, protein kinase C (PKC) isoforms and extracellular-signal-regulated kinase (ERK) [ 48 , 49 , 50 ]. Furthermore, these small proteins mediate several responses in stress adaptation processes [ 51 ]. The isoforms caveolin 1 and 2 are expressed in a variety of cell types, e.g., endothelial cells [ 52 ].…”

Section: Helium—a Noble Gasmentioning

confidence: 99%

Pharmacological Conditioning of the Heart: An Update on Experimental Developments and Clinical Implications

Roth

Torregroza

Feige

et al. 2021

IJMS

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The aim of pharmacological conditioning is to protect the heart against myocardial ischemia-reperfusion (I/R) injury and its consequences. There is extensive literature that reports a multitude of different cardioprotective signaling molecules and mechanisms in diverse experimental protocols. Several pharmacological agents have been evaluated in terms of myocardial I/R injury. While results from experimental studies are immensely encouraging, translation into the clinical setting remains unsatisfactory. This narrative review wants to focus on two aspects: (1) give a comprehensive update on new developments of pharmacological conditioning in the experimental setting concentrating on recent literature of the last two years and (2) briefly summarize clinical evidence of these cardioprotective substances in the perioperative setting highlighting their clinical implications. By directly opposing each pharmacological agent regarding its recent experimental knowledge and most important available clinical data, a clear overview is given demonstrating the remaining gap between basic research and clinical practice. Finally, future perspectives are given on how we might overcome the limited translatability in the field of pharmacological conditioning.

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Section: Helium—a Noble Gasmentioning

confidence: 99%

Pharmacological Conditioning of the Heart: An Update on Experimental Developments and Clinical Implications

Roth

Torregroza

Feige

et al. 2021

IJMS

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“…The role of caveolins in ischaemic and isoflurane-induced conditioning has been shown before [47–49]. Moreover, caveolins play a central role in several stress adaptation processes of different organs and tissues [50]. With their scaffolding domains caveolins can anchor and regulate cell proteins having been implicated in helium induced conditioning [51].…”

Section: A Novel Target For Helium Conditioning: Membrane Proteins “Cmentioning

confidence: 99%

“…A recent review on caveolins summarizes the different cellular functions, e.g. as chaperones and scaffold recruiting signalling molecules [50]. As caveolins are considered to play a key role in the regulation of several multi-protein complexes [53], it is of special interest that many of the signalling molecules involved in cardiac protection by conditioning, including the G-alpha subunit of heterotrimeric G-proteins, Src kinases, PI 3 K, eNOS, PKC isoforms and ERK, are known to be regulated by caveolins [54, 55].…”

Section: A Novel Target For Helium Conditioning: Membrane Proteins “Cmentioning

confidence: 99%

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Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons

Weber

Preckel

2019

ICMx

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Noble gases, although supposed to be chemically inert, mediate numerous physiological and cellular effects, leading to protection against ischaemia-reperfusion injury in different organs. Clinically, the noble gas helium is used in treatment of airway obstruction and ventilation disorders in children and adults. In addition, studies from recent years in cells, isolated tissues, animals and finally humans show that helium has profound biological effects: helium applied before, during or after an ischaemic event reduced cellular damage, known as “organ conditioning”, in some tissue, e.g. the myocardium. Although extensive research has been performed, the exact molecular mechanisms behind these organ-protective effects of helium are yet not completely understood. In addition, there are significant differences of protective effects in different organs and animal models. A translation of experimental findings to the clinical situation has yet not been shown.

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“…Lipid rafts availability is tightly regulated through changes in lipid metabolism, receptor activation and cytoskeleton (6), but the exact mechanisms of how lipid raft regulation is integrated with other levels of metabolic regulation is poorly understood. It is easy to envisage how deficiency of rafts, such as caveolae, can restrict a vital pathway (7). Less intuitive is a situation when an excess of rafts leads to a pathway being enhanced beyond control, and yet, this is a common occurrence; inflammation, where excessive lipid rafts result in excessive and poorly controlled inflammation, being a good example.…”

mentioning

confidence: 99%

Biology of Lipid Rafts: Introduction to the Thematic Review Series

Sviridov

Miller

2020

Journal of Lipid Research

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Lipid rafts are organized plasma membrane microdomains, which provide a distinct level of regulation of cellular metabolism and response to extracellular stimuli, affecting a diverse range of physiologic and pathologic processes. This Thematic Review Series focuses on Biology of Lipid Rafts rather than on their composition or structure. The aim is to provide an overview of ideas on how lipid rafts are involved in regulation of different pathways and how they interact with other layers of metabolic regulation. Articles in the series will review the involvement of lipid rafts in regulation of hematopoiesis, production of extracellular vesicles, host interaction with infection, and the development and progression of cancer, neuroinflammation, and neurodegeneration, as well as the current outlook on therapeutic targeting of lipid rafts.

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Caveolins as Regulators of Stress Adaptation

Cited by 15 publications

References 152 publications

Pharmacological Conditioning of the Heart: An Update on Experimental Developments and Clinical Implications

Pharmacological Conditioning of the Heart: An Update on Experimental Developments and Clinical Implications

Gaseous mediators: an updated review on the effects of helium beyond blowing up balloons

Biology of Lipid Rafts: Introduction to the Thematic Review Series

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