Cavitas Sensors: Contact Lens Type Sensors &amp; Mouthguard Sensors

Mitsubayashi, Kohji; Arakawa, Takahiro

doi:10.1002/elan.201600083

Cited by 64 publications

(39 citation statements)

References 164 publications

(187 reference statements)

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“…Chemical biomarkers, which can be used as indicators for specific diseases, are contained in tears. Tears have important functions, such as lubricating the cornea and conjunctiva, keeping the mucous membranes that form the ocular surface moist, nourishing the underlying cells, protecting the eyes against pathogens, and forming a flat, smooth layer on the uneven surface of the cornea …”

Section: Biomarkers In Eyes For Diagnosis Of Diseasesmentioning

confidence: 99%

Recent Advances in Smart Contact Lenses

Kim

Cha

Park

2019

Adv Materials Technologies

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The eyes can provide rich physiological information and offer broad diagnostic potential as a sensing site, making the use of contact lens sensors viable for noninvasive monitoring of many diseases and conditions. Therefore, extensive research efforts recently are devoted to the development of smart contact lenses for healthcare monitoring. Herein, physical biomarkers, which can be obtained from the eyes, and chemical biomarkers, which can be obtained from tears are discussed. Then, the latest advances in smart contact lenses with biosensors that diagnose diseases are reviewed. The subsequent content summarizes and classifies the techniques that can be used for the transmission of data based on the methods to deliver physiological information. In addition, representative examples of other devices for drug delivery energy storage are provided, and the challenges that should be overcome to develop smart contact lenses are discussed.

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Section: Biomarkers In Eyes For Diagnosis Of Diseasesmentioning

confidence: 99%

Recent Advances in Smart Contact Lenses

Kim

Cha

Park

2019

Adv Materials Technologies

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“…Widespread acceptance of wearable sensor technology requires the creation of products that can be easily integrated into an individual's lifestyle Most wearable chemical sensors have relied on sweat analysis in connection to flexible and temporary tattoo-like devices, 3,22,23 head bands, 24 or wrist bands. 14 Other platforms and accessories explored recently for on-body chemical sensing applications include mouthguards for saliva monitoring, 13,25 contact lenses for tear assays 26,27 or smart bandages for wound healing. 18,28 As the wearable sensor technology advances, there are urgent needs for addressing the challenges of merging the strengths of the fashion and wearable fields to create wearable fashion accessories that will lead to a widespread acceptance of wearable sensor technology.…”

Section: Introductionmentioning

confidence: 99%

Eyeglasses based wireless electrolyte and metabolite sensor platform

et al. 2017

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The demand for wearable sensors has grown rapidly in recent years, with increasing attention being given to epidermal chemical sensing. Here, we present the first example of a fully-integrated eyeglasses wireless multiplexed chemical sensing platform capable of real-time monitoring of sweat electrolytes and metabolites. The new concept has been realized by integrating an amperometric lactate biosensor and a potentiometric potassium ion-selective electrode on the two nose bridge pads of the glasses and interfacing them to a wireless electronic backbone placed on the glasses arms. Simultaneous real-time monitoring of sweat lactate and potassium levels with no apparent cross-talk is demonstrated along with wireless signal transduction. The electrochemical sensors were screen printed on a polyethylene terephthalate (PET) stickers and placed on each side of the glasses nose pads in order to monitor sweat metabolites and electrolytes. The electronic backbone on the arms of the glasses frame offers control of the amperometric and potentiometric transducers and enables Bluetooth wireless data transmission to the host device. The new glasses system offers an interchangeable-sensor feature in connection to variety of different nose-bridge amperometric and potentiometric sensor stickers. For example, the lactate bridge-pad sensor was replaced with a glucose one to offer convenient monitoring of sweat glucose. Such fully-integrated wireless “Lab-on-a-Glass” multiplexed biosensor platform can be readily expanded for the simultaneous monitoring of additional sweat electrolytes and metabolites.

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“…Additionally, not all types of textiles are suitable to integrate sensing materials [38][39][40]. As an alternative, other flexible thin-film substrates (e.g., paper and plastic) have been explored [41][42][43][44][45][46]. However, the intrinsic fracture limit of the flexible thin-film materials is small (e.g., <1% for paper).…”

Section: Introductionmentioning

confidence: 99%

Recent Developments of Flexible and Stretchable Electrochemical Biosensors

Yang

Cheng

2020

Micromachines

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The skyrocketing popularity of health monitoring has spurred increasing interest in wearable electrochemical biosensors. Compared with the traditionally rigid and bulky electrochemical biosensors, flexible and stretchable devices render a unique capability to conform to the complex, hierarchically textured surfaces of the human body. With a recognition element (e.g., enzymes, antibodies, nucleic acids, ions) to selectively react with the target analyte, wearable electrochemical biosensors can convert the types and concentrations of chemical changes in the body into electrical signals for easy readout. Initial exploration of wearable electrochemical biosensors integrates electrodes on textile and flexible thin-film substrate materials. A stretchable property is needed for the thin-film device to form an intimate contact with the textured skin surface and to deform with various natural skin motions. Thus, stretchable materials and structures have been exploited to ensure the effective function of a wearable electrochemical biosensor. In this mini-review, we summarize the recent development of flexible and stretchable electrochemical biosensors, including their principles, representative application scenarios (e.g., saliva, tear, sweat, and interstitial fluid), and materials and structures. While great strides have been made in the wearable electrochemical biosensors, challenges still exist, which represents a small fraction of opportunities for the future development of this burgeoning field.

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Cavitas Sensors: Contact Lens Type Sensors & Mouthguard Sensors

Cited by 64 publications

References 164 publications

Recent Advances in Smart Contact Lenses

Recent Advances in Smart Contact Lenses

Eyeglasses based wireless electrolyte and metabolite sensor platform

Recent Developments of Flexible and Stretchable Electrochemical Biosensors

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